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| CAS No.: | 144034-80-0 |
|---|---|
| Name: | Rizatriptan |
| Article Data: | 21 |
| Molecular Structure: | |
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| Formula: | C15H19N5 |
| Molecular Weight: | 269.349 |
| Synonyms: | 3-[2-(Dimethylamino)ethyl]-5-(1H-1,2,4-triazol-1-ylmethyl)indole;MK 462 free base;N,N-Dimethyl-2-[5-(1H-1,2,4-triazol-1-ylmethyl)-1H-indol-3-yl]ethylamine;Risatriptan;Rizatriptan; |
| Density: | 1.21 g/cm3 |
| Melting Point: | 178-180 °C |
| Boiling Point: | 504.8 °C at 760 mmHg |
| Flash Point: | 259.1 °C |
| Solubility: | water: 42 mg/mL |
| PSA: | 49.74000 |
| LogP: | 1.91180 |
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Chemistry
Rizatriptan (144034-80-0) is a 5-HT1 agonist triptan drug developed by Merck & Co. for the treatment of migraine headaches. It is available in strengths of 5 and 10 mg as tablets and orally disintegrating tablets (Maxalt-MLT).
Maxalt obtained approval by the United States Food and Drug Administration (FDA) on June 29, 1998. It is a second-generation triptan.
Rizatriptan(144034-80-0) is available only by prescription in the United States, Canada and New Zealand. Similarly, it is classed as a POM (Prescription Only Medicine) in the United Kingdom, Italy (as Rizaliv) and Israel (as Rizalt).
The density of Rizatriptan(144034-80-0) is 1.21 g/cm3 and it has a melting point of 178-180°C. The boiling point is 504.8 °C at 760 mmHg. The refractive index is about 1.645. Its flash point is 259.1 °C.
The chemical synonyms of Rizatriptan(144034-80-0) are n,n-dimethyl-5-(1h-1,2,4-triazol-1-ylmethyl)-1h-indole-3-ethanamine;n,n-dimethyl-2-[5-(1,2,4-triazol-1-ylmethyl)-1h-indol-3-yl]ethanamine;RIZATRIPTAN
The molecular structure of Rizatriptan(144034-80-0):