CAS No.144510-96-3,Benz[g]isoquinoline-5,10-dione,6,9-bis[(2-aminoethyl)amino]- Suppliers

Detail of "144510-96-3"

CAS Number:

144510-96-3

Name:

Superlist Name:

Molecular Structure:

Formula:

C₁₇H₁₉N₅O₂

Molecular Weight:

325.37

Synonyms:

6,9-Bis[(2-aminoethyl)amino]benz[g]isoquinoline-5,10-dione;

Density:

1.405 g/cm³

Boiling Point:

650 °C at 760 mmHg

Flash Point:

346.9 °C

Pixantrone (BBR2778): a new immunosuppressant in multiple sclerosis with a low cardiotoxicity: Pixantrone (BBR2778): a new immunosuppressant in multiple sclerosis with a low cardiotoxicity. Gonsette, R. E. (National Center for Multiple Sclerosis, Melsbroek B-1820, Belg.). Journal of the Neurological Sciences, 223(1), 81-86 (English) 2004 Elsevier Science B.V. CODEN: JNSCAG. ISSN: 0022-510X. DOCUMENT TYPE: Journal; General Review CA Section: 1 (Pharmacology) A review. Mitoxantrone (MX) has been approved by the Food and Drug Administration for the treatment of rapidly progressive multiple sclerosis (MS). Unfortunately, its long-term administration is prevented by the cardiotoxicity. Pixantrone (PIX) is an analog of MX devoid of toxic effects on cardiac tissue and was developed as a replacement for other anthracenediones in cancer patients. 144675-97-8 and 144510-96-3 which are cas registry numbers of chemicals are mentioned. With a view to an application in MS patients, exptl. data demonstrated that PIX is as potent as MX in preventing acute exptl. allergic encephalomyelitis development as well as the occurrence of relapses in the chronic model. Safety data from animal studies and from phase II trials in cancer patients confirm a very weak cardiotoxicity, if any. A phase I trial with PIX in patients with a rapidly progressive MS seems thus warranted. .

Detail of "144510-96-3"