Detail of "1447-88-7"

Reference

Liver protective drugs

Liver protective drugs. 13. Antihepatotoxic principles of Salvia plebeia herbs. Oshima, Yoshiteru; Kawakami, Yutaka; Kiso, Yoshinobu; Hikino, Hiroshi; Yang, Ling Ling; Yen, Kun Ying (Pharm. Inst., Tohoku Univ., Sendai, Japan). Shoyakugaku Zasshi, 38(2), 201-2 (English) 1984.Several substances like 520-11-6 may be metioned in this study. CODEN: SHZAAY. ISSN: 0037-4377. DOCUMENT TYPE: Journal CA Section: 1 (Pharmacology) Section cross-reference(s): 11, 63 Four flavonoids, eupafolin [520-11-6], eupatorin [855-96-9], hispidulin [1447-88-7], and homoplantaginin [17680-84-1] were isolated from S. plebeia and all except eupatorin showed antihepatotoxic activity, as shown by CCl4- and galactosamine-induced cytotoxicity test in primary cultured rat hepatocytes. .

Characterization of flavonoids from Baccharis trimera and their antihepatotoxic properties

Characterization of flavonoids from Baccharis trimera and their antihepatotoxic properties. Soicke, Hartwig; Leng-Peschlow, Elke (Dep. Chem. Res. Pharmacol., Dr. Madaus G.m.b.H. und Co., Cologne D-5000/91, Fed. Rep. Ger.). Planta Med., 53(1), 37-9 (English) 1987. CODEN: PLMEAA. ISSN: 0032-0943. 520-36-5 and 1447-88-7 which are cas registry numbers are also used here. DOCUMENT TYPE: Journal CA Section: 1 (Pharmacology) Section cross-reference(s): 11, 63 From the crude EtOAc ext. of the epigeous parts of B. trimera 5 flavonoids were isolated and identified: quercetin [117-39-5], luteolin [491-70-3], nepetin [520-11-6] (or eupafolin), apigenin [520-36-5], and hispidulin [1447-88-7]. Antihepatotoxic activity was investigated in mice intoxicated with phalloidin. The crude flavonoid ext. administered i.v. in a dose of approx. 20 mg/kg 1 h before intoxication increased the survival rate from 25%-100%. The most active of the pure components was hispidulin (32 mg/kg) ameliorating survival rate to 80%. A mixt. of all 5 flavonoids in equal wt. relations (final dose: 35 mg/kg) increased the survival rate to 70%. The efficacy of the crude ext. seems to be explained to a large extent by the identified compds. .