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145-63-1

Basic Information
CAS No.: 145-63-1
Name: 8,8'-[carbonylbis[imino-3,1-phenylenecarbonylimino(4-methyl-3,1-phenylene)carbonylimino]]bisnaphthalene-1,3,5-trisulphonic acid
Molecular Structure:
Molecular Structure of 145-63-1 (8,8'-[carbonylbis[imino-3,1-phenylenecarbonylimino(4-methyl-3,1-phenylene)carbonylimino]]bisnaphthalene-1,3,5-trisulphonic acid)
Formula: C51H40 N6 O23 S6
Molecular Weight: 1297.3
Synonyms: 1,3,5-Naphthalenetrisulfonicacid,8,8'-[ureylenebis[m-phenylenecarbonylimino(4-methyl-m-phenylene)carbonylimino]]di-(8CI);8,8'-[Ureylenebis[m-phenylenecarbonylimino(4-methyl-m-phenylene)carbonylimino]]di-1,3,5-naphthalenetrisulfonicacid; Farma; Farma 939; Fourneau; Metaret; Naganol; Suramin; Suramine
Density: g/cm3
Melting Point: 128 °C(Solv: ethyl ether (60-29-7))
Boiling Point: °Cat760mmHg
Flash Point: °C
Safety: Moderately toxic by intravenous route. Human systemic effects by intravenous route: eye effects. An experimental teratogen. Other experimental reproductive effects. When heated to decomposition it emits very toxic fumes of SOx and NOx.
PSA: 534.03000
LogP: 13.66600
Synthetic route
145-63-1

suramin

30516-87-1

3'-azido-2',3'-deoxythymidine

suramin-3’-azido-2’,3’-dideoxythymidine

Conditions
ConditionsYield
With phosphorus pentoxide In N,N-dimethyl-formamide
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    Melting point 128 °C(Solv: ethyl ether (60-29-7)) density 1.2629 (rough estimate) refractive index 1.7770 (estimate) pka -1.35&pl

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    SuraMin CAS NO.145-63-1

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Chemistry

Following is the structure of Bayer 205 (CAS No.145-63-1):


Molecular Formula: C51H40N6O23S6
Molecular Weight: 1297.28 g/mol
IUPAC NAME: 8-[[4-methyl-3-[[3-[[3-[[2-methyl-5-[(4,6,8-trisulfonaphthalen-1-yl)carbamoyl]phenyl]carbamoyl]phenyl]carbamoylamino]benzoyl]amino]benzoyl]amino]naphthalene-1,3,5-trisulfonic acid 
The chemical synonymous of Bayer 205 (CAS No.145-63-1) are 8,8'-[Carbonylbis[Imino-3,1-Phenylenecarbonylimino(4-Methyl-3,1-Phenylene)Carbonylimino]]Bisnaphthalene-1,3,5-Trisulphonic Acid ; Farma 939 ; Fourneau ; Naphuride ; Suramine
CAS No.: 145-63-1
EINECS: 205-658-4
Density: 1.794 g/cm3 
Index of Refraction: 1.777
Molar Refractivity: 302.38 cm3
Molar Volume: 722.7 cm3
Surface Tension: 105.6 dyne/cm
Classification Code of Bayer 205 (CAS No.145-63-1):  Anthelmintics ; Anti-Infective Agents ; Antinematodal agents ; Antineoplastic agents ; Antiparasitic Agents ; Antiprotozoal Agents ; Drug / Therapeutic Agent ; Human Data ; Reproductive Effect ; Trypanocidal agents

Toxicity Data With Reference

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
man TDLo intravenous 46mg/kg/5W-I (46mg/kg) SENSE ORGANS AND SPECIAL SENSES: OTHER: EYE New England Journal of Medicine. Vol. 314, Pg. 1455, 1986.
mouse LD50 intravenous 620mg/kg (620mg/kg) KIDNEY, URETER, AND BLADDER: "CHANGES IN TUBULES (INCLUDING ACUTE RENAL FAILURE, ACUTE TUBULAR NECROSIS)" Advances in Pharmacology and Chemotherapy. Vol. 15, Pg. 289, 1978.

Safety Profile

Moderately toxic by intravenous route. Human systemic effects by intravenous route: eye effects. An experimental teratogen. Other experimental reproductive effects. When heated to decomposition it emits very toxic fumes of SOx and NOx.