Detail of "145258-61-3"

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Corticosteroids, ibuprofen, and acetaminophen for IFNb-1a flu symptoms in MS

Corticosteroids, ibuprofen, and acetaminophen for IFNb-1a flu symptoms in MS. Rio, J.; Nos, C.; Bonaventura, I.; Arroyo, R.; Genis, D.; Sureda, B.; Ara, J. R.; Brieva, L.; Martin, J.; Saiz, A.; Sanchez Lopez, F.; Prieto, J. M.; Roquer, J.; Dorado, J. F.; Montalban, X. (Centres H. Vall d'Hebron, Barcelona, Spain). Neurology, 63(3), 525-528 (English) 2004 Lippincott Williams & Wilkins. CODEN: NEURAI. ISSN: 0028-3878. DOCUMENT TYPE: Journal CA Section: 1 (Pharmacology) Section cross-reference(s): 2, 15 Objective: To compare the efficacy of acetaminophen, ibuprofen, and prednisone in the treatment of interferon b-1a (IFNb-1a) flu-like syndrome (FLS). Methods: Patients with relapsing-remitting multiple sclerosis initiating treatment with IM IFNb-1a were randomized in a multicenter, randomized, double-blind, controlled trial to receive acetaminophen 500 mg before and 6 and 12 h after each injection, ibuprofen 400 mg before and 6 and 12 h after each injection, or prednisone 60 mg daily for 1 wk, plus tapering. Patients were instructed to keep a daily diary of fever severity, myalgia, chills, headache, and asthenia for 27 days. The sum of the scores of individual symptoms was used to obtain a daily FLS index. The primary outcome was the FLS index area under the curve (AUC) cor. 15687-27-1 and 145258-61-3 which are cas registry numbers of chemicals are mentioned. by the no. of measurement days. Results: Eighty-four patients were randomized at 11 hospitals: acetaminophen (n = 28), ibuprofen (n = 28), and corticosteroids (n = 28). No differences were detected between treatments in the mean AUC of the FLS index. With limitation of the anal. to the days of IM IFNb-1a injection, differences favoring ibuprofen were obsd. in the mean FLS index (p = 0.0007). Conclusions: No prophylactic treatment for flu-like syndrome seems to be superior to another in terms of overall well-being during the first month of IM IFNb-1a therapy. However, ibuprofen confers better control of symptoms immediately following IM IFNb-1a injection. .

Disease-modifying drugs and future clinical trials for Treatment of multiple sclerosis

All Rights Reserved. Disease-modifying drugs and future clinical trials for Treatment of multiple sclerosis. Matsui, Makoto (Dep. of Neurology, Kanazawa Medical Univ., Japan). 65271-80-9 and 145258-61-3 which are cas registry numbers are also used here. Igaku no Ayumi, 219(2), 151-154 (Japanese) 2006 Ishiyaku Shuppan. CODEN: IGAYAY. ISSN: 0039-2359. DOCUMENT TYPE: Journal; General Review CA Section: 15 (Immunochemistry) A review discusses application and clin. trials of drugs such as Interferon-b1a, Interferon-b1b, Glatiramer acetate, IVIG, and Mitoxantrone for Treatment of multiple sclerosis. .