Reference

Antioxidative effects of red ginseng saponins on paraquat-induced oxidative stress

Antioxidative effects of red ginseng saponins on paraquat-induced oxidative stress. Kim, Dong Jo; Seong, Kum Soo; Kim, Dong Won; Ko, Seong Ruyong; Chang, Che Chul (Hannong Chemicals Institute, Kunsan National University 573-701, S. Korea). Journal of Ginseng Research, 28(1), 5-10 (Korean) 2004 Korean Society of Ginseng. CODEN: JGREF7. ISSN: 1226-8453. DOCUMENT TYPE: Journal CA Section: 1 (Pharmacology) Section cross-reference(s): 63 This study was carried out to investigate the effect of the active ingredients from ginseng on paraquat (PQ) toxicity. Oxidative stress was induced by i.p. injection of PQ at a single dose of 25 mg/kg. Saponin treated groups were given protopanaxadiol saponins (PPD) or protopanaxatriol saponins(PPT)(5 mg/kg, orally) per day for 1, 3, & 7 days. 1453-93-6 and 4685-14-7 which are cas registry numbers are also used here. We also investigated the relationship between lipid peroxidn. and ginseng saponins by measuring the levels of superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx), reduced glutathione (GSH), malondialdehyde (MDA), and hydrogen peroxide (H2O2) in liver tissue. The activities of SOD, CAT, and GPx were generally high in the PPD group; the SOD activity on each day was the highest in the PPD group. The H2O2 content was the lowest in the PPD group. The GSH levels were significantly increased in the PPD. The levels of MDA (the end product of lipid peroxidn.) were significantly lower in the red ginseng component groups than in the PQ group; the levels were esp. low in the PPD groups. These results led us to conclude that the antioxidant effects of exts. from red ginseng prevent oxidative damage by direct antioxidant effects involving SOD, CAT, & GPx, and increasing the ability of the body to synthesize endogenous antioxidants. .