Detail of "1460-34-0"

Reference

Metabolism of orally administered branched-chain a-keto acids

Metabolism of orally administered branched-chain a-keto acids. Dalton, R. Neil; Chantler, Cyril (Dep. Paediatr., Guy's Hosp., London, UK). Kidney Int., Suppl., 24(15), 11-15 (English) 1983. CODEN: KISUDF. ISSN: 0098-6577. DOCUMENT TYPE: Journal CA Section: 18 (Animal Nutrition) Section cross-reference(s): 1 The changes in serum branched-chain a-keto acid (BCKA) and plasma amino acid concns., in response to a therapeutic oral dose of an essential amino acid-keto acid mixt.In this article, certain chemicals are used. Some of their cas registry numbers are 1509-34-8 and 73-32-5 , were studied in fasting healthy adults. Of the branched-chain amino acids (BCAA), only the plasma leucine [61-90-5] concn. rose despite increases in all 3 serum BCKA concns. The plasma valine [72-18-4] concn. tended rise, but plasma isoleucine [73-32-5] concns. fell. When ketoisoleucine [1460-34-0] was given alone there followed an increase in plasma isoleucine concn. and a fall in valine and leucine. Similarly, when ketovaline [759-05-7] was given, plasma valine rose and leucine and isoleucine fell. These results suggest some transamination of the keto acid with amino groups of the other BCAA. Ketoleucine (KICA) [816-66-0], however, produced larger falls in plasma valine and isoleucine than was expected from the rise in leucine. In addn., KICA caused insulin-independent redns. in plasma threonine [72-19-5], serine [56-45-1], cystine [56-89-3], methionine [63-68-3], tyrosine [60-18-4], phenylalanine [63-91-2], and alanine [56-41-7]. Thus, although orally administered BCKA will increase the BCAA supply, their value may not simply relate to the supply of essential amino acids for protein synthesis but to a direct effect of KICA on protein metab. .

Relationship between intake and rate of oxidation of leucine and a-ketoisocaproate in vivo in the rat

Relationship between intake and rate of oxidation of leucine and a-ketoisocaproate in vivo in the rat. Harper, A. E.; Benjamin, E. (Dep. Nutr. Sci., Univ. Wisconsin, Madison, WI 53706, USA). J. Nutr., 114(2), 431-40 (English) 1984. CODEN: JONUAI. ISSN: 0022-3166. DOCUMENT TYPE: Journal CA Section: 18 (Animal Nutrition) Rates of oxidn. of leucine [61-90-5] by rats fed, ad libitum, diets contg. graded amts. (0-2.4%) of leucine together with L-[1-14C]leucine were measured for 12 h. The amt. of leucine oxidized was low until dietary leucine content exceeded that needed for max. rate of wt. gain. Thereafter, the rate of leucine oxidn. increased essentially linearly with increasing dietary leucine content. Rates of oxidn. of a-ketoisocaproic acid (KIC) [816-66-0] by rats fed, ad libitum, diets devoid of leucine to which graded amts. (0-2.05%) of KIC were added together with [1-14C]KIC were also measured for 12 h. The amt. of KIC oxidized increased as dietary KIC content was increased over the entire range of dietary levels tested. 759-05-7 and 72-18-4 which are cas registry numbers of substances are two of reagents here. At the end of the 12-h oxidn. studies, plasma valine [72-18-4], a-ketoisovaleric acid [759-05-7], isoleucine [73-32-5], and a-keto-b-methylvaleric acid [1460-34-0] concns. were depressed when dietary levels of leucine were high. Plasma leucine and KIC concns. were low when dietary levels of leucine were low and increased with increasing dietary leucine content. Leucine and KIC concns. in plasma of rats fed a diet devoid of leucine did not increase in proportion to increasing dietary KIC content. .