Detail of "14683-61-5"

CAS Number:
14683-61-5
Name:
b-D-Glucopyranosiduronic acid,8-quinolinyl
Molecular Structure:
Formula:
C15H15 N O7
Molecular Weight:
321.31
Synonyms:
Glucopyranosiduronicacid, 8-quinolyl, b-D- (8CI); 8-Hydroxyquinoline glucuronide; 8-Quinolinyl glucuronide;8-Quinolyl b-D-glucosiduronic acid; NSC 87518
Density:
1.626g/cm³
Boiling Point:
639.9°Cat760mmHg
Flash Point:
340.8°C
Appearance:
powder light green
Safety:
Mutation data reported. When heated to decomposition it emits toxic vapors of NO_x. Details

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8-HYDROXYQUINOLINE GLUCURONIDE

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Pharmacokinetic study on the fate of 8-hydroxyquinoline in the rat: Pharmacokinetic study on the fate of 8-hydroxyquinoline in the rat. Kiwada, Hiroshi; Hayashi, Masahiro; Fuwa, Tohru; Awazu, Shoji; Hanano, Manabu (Fac. Pharm. Sci., Univ. Tokyo, Tokyo, Japan). Chem. Pharm. Bull., 25(7), 1566-73 (English) 1977. CODEN: CPBTAL. DOCUMENT TYPE: Journal CA Section: 1 (Pharmacodynamics) In rats, both 8-hydroxyquinoline (Oxime)(I) [148-24-3] and iodochlorhydroxyquin (II) [130-26-7] were metabolized to glucuronide and sulfate conjugates. However, after administration of I, more I glucuronide [14683-61-5] was excreted in urine than I sulfate [2149-36-2], whereas after II administration, more II sulfate [16524-58-6] was excreted in urine than II glucuronide [34296-97-4]. Only the glucuronides of I and II were excreted in the bile. In addn., after administration of I glucuronide and I sulfate, both compds. were excreted unchanged in the bile and urine. Thus, the metab. of I and II was influenced by the halogen groups on II. A method is described for the detn. of I and its glucuronide and sulfate conjugates in blood using the 14C-labeled compd.