Detail of "147098-20-2"

CAS Number:
147098-20-2
Name:
Rosuvastatin calcium
Molecular Structure:
Formula:
2(C₂₂H₂₇FN₃O₆S)^.Ca
Molecular Weight:
1001.14
Synonyms:
7-{4-(4-Fluorophenyl)-6-isopropyl-2-[methyl(methylsulfonyl)amino]pyrimidin-5-yl}-3,5-dihydroxyhept-6-enoic acid;
Melting Point:
122 °C
Boiling Point:
745.6 °C at 760 mmHg
Flash Point:
404.7 °C
Appearance:
white to off-white crystalline solid

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CAS No.147098-20-2 Rosuvastatin calcium

(3R,5S,6E)-7-[4-(4-fluorophenyl)-6-(1-methylethyl)-2-[N-methyl(n-methylsulfonyl)amino]-5-pyrim

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Single dosage form of complicated pellet for preventing atherosclerosis of diabetics comprising hypoglycemic agents, HMG-CoA reductase inhibitors and enteric coated aspirin, particularly for improving dosage convenience: All Rights Reserved. Single dosage form of complicated pellet for preventing atherosclerosis of diabetics comprising hypoglycemic agents, HMG-CoA reductase inhibitors and enteric coated aspirin, particularly for improving dosage convenience. Yu, Chang Hun; Gil, Young Sig; Kim, Hye Kyeong; Jeong, Sang Young; Ahn, Ki Young; Yang, Geun Woo; Shin, Hyun Mo; Park, Sang Man; Ha, Dae Chul (Korea United Pharm. Inc., S. Korea). Repub.Some commonly used reagents like 93479-97-1 and 147098-20-2 are used in this experiment. Korean Kongkae Taeho Kongbo KR 2006093467 A 25 Aug 2006, No pp. given (Korean). (Korea, Republic Of). CODEN: KRXXA7. APPLICATION: KR 2005-14306 22 Feb 2005. DOCUMENT TYPE: Patent CA Section: 63 (Pharmaceuticals) A single dosage form of complicated pellet for preventing atherosclerosis of diabetics is provided to improve use convenience of a patient in view of dosage time and dosage method by contg. aspirin, hypoglycemic agents, and HMG-CoA reductase inhibitor, so that treatment effects are maximized. The single dosage form of complicated pellet for preventing atherosclerosis of diabetics comprises: a main layer contg. 25-35% of aspirin in 40-55% of inert sugar particles; the enteric coated layer contg. 10-15% of enteric materials in the outside of the main layer; and an exterior layer coated with drugs contg. 0.2-2.5% of sulfonyl urea-based hypoglycemic agents and 2.5-15% of HMG-CoA reductase inhibitors, wherein the sulfonyl urea-based hypoglycemic agent is glimepiride or glibenclamide; and the HMG-CoA reductase inhibitor is simvastatin, atorvastatin calcium or rosuvastatin calcium. .

Rosuvastatin: a new inhibitor of HMG-CoA reductase for the treatment of dyslipidemia: Rosuvastatin: a new inhibitor of HMG-CoA reductase for the treatment of dyslipidemia. Rosenson, Robert S. (Preventive Cardiology Center, The Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA). Expert Review of Cardiovascular Therapy, 1(4), 495-505 (English) 2003 Future Drugs Ltd. CODEN: ERCTAS. ISSN: 1477-9072. DOCUMENT TYPE: Journal; General Review CA Section: 1 (Pharmacology) A review. Rosuvastatin (Crestor, AstraZeneca) is a synthetic statin that represents an advance on the pharmacol. and clin. properties of other agents in this class. Relative to other statins, rosuvastatin possesses a greater no. of binding interactions with HMG-CoA reductase and has a high affinity for the active site of the enzyme. Rosuvastatin is relatively hydrophilic and is selectively taken up by, and active in, hepatic cells. Rosuvastatin has the longest terminal half-life of the statins and is only minimally metabolized by the cytochrome P 450 (CYP 450) enzyme system with no significant involvement of the 3A4 enzyme. Consistent with this finding is the absence of clin. significant drug interactions between rosuvastatin and other drugs known to inhibit CYP 450 enzymes. In patients with hypercholesterolemia, rosuvastatin 10-40 mg has been shown to reduce low-d. 9028-35-7 and 147098-20-2 which are cas registry numbers of chemicals are mentioned. lipoprotein cholesterol (LDL-C) levels by 52-63%, as well as increase high-d. lipoprotein cholesterol (HDL-C) levels by up to 14% and reduce triglycerides (TG) by up to 28%. Studies have shown that rosuvastatin is superior to atorvastatin, simvastatin and pravastatin in reducing LDL-C and favorably modifying other components of the atherogenic lipid profile. The significant decreases in LDL-C with rosuvastatin treatment should help to improve attainment of lipid goals and reduce the requirement for dose titrn. In addn., the effects of rosuvastatin on HDL-C and TG levels will be of benefit in treating patients with abnormalities such as mixed dyslipidemia and the metabolic syndrome. Rosuvastatin is welt tolerated, with a safety profile comparable with that of other currently available statins. .

Detail of "147098-20-2"

Rosuvastatin calcium

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CAS No.147098-20-2 Rosuvastatin calcium

CAS No.147098-20-2 Rosuvastatin calcium

CAS No.147098-20-2 Rosuvastatin calcium

CAS No.147098-20-2 Rosuvastatin calcium

CAS No.147098-20-2 Rosuvastatin calcium

CAS No.147098-20-2 Rosuvastatin calcium

CAS No.147098-20-2 Rosuvastatin calcium

CAS No.147098-20-2 Rosuvastatin calcium

CAS No.147098-20-2 Rosuvastatin calcium

CAS No.147098-20-2 Rosuvastatin calcium

CAS No.147098-20-2 Rosuvastatin calcium

CAS No.147098-20-2 Rosuvastatin calcium

CAS No.147098-20-2 Rosuvastatin calcium

CAS No.147098-20-2 Rosuvastatin calcium

CAS No.147098-20-2 Rosuvastatin calcium

CAS No.147098-20-2 Rosuvastatin calcium

CAS No.147098-20-2 Rosuvastatin calcium

CAS No.147098-20-2 Rosuvastatin calcium

CAS No.147098-20-2 Rosuvastatin calcium

CAS No.147098-20-2 Rosuvastatin calcium

CAS No.147098-20-2 Rosuvastatin calcium

CAS No.147098-20-2 Rosuvastatin calcium

CAS No.147098-20-2 Rosuvastatin calcium

CAS No.147098-20-2 Rosuvastatin calcium

CAS No.147098-20-2 Rosuvastatin calcium

CAS No.147098-20-2 Rosuvastatin calcium

CAS No.147098-20-2 Rosuvastatin calcium

CAS No.147098-20-2 Rosuvastatin calcium

CAS No.147098-20-2 Rosuvastatin calcium

CAS No.147098-20-2 Rosuvastatin calcium

CAS No.147098-20-2 Rosuvastatin calcium

CAS No.147098-20-2 Rosuvastatin calcium

CAS No.147098-20-2 Rosuvastatin calcium

CAS No.147098-20-2 Rosuvastatin calcium

CAS No.147098-20-2 Rosuvastatin calcium

CAS No.147098-20-2 Rosuvastatin calcium

CAS No.147098-20-2 Rosuvastatin calcium

CAS No.147098-20-2 Rosuvastatin calcium

Reference