Welcome to LookChem.com Sign In|Join Free
  • or
Home > Pharmaceutical > 147489 > 

147489-06-3

Products Categories

Basic Information
CAS No.: 147489-06-3
Name: (4R,6S)-6-[(1E)-2-[2-Cyclopropyl-4-(4-fluorophenyl)-3-quinolinyl]ethenyl]-2,2-dimethyl-1,3-dioxane-4-acetic acid tert-butyl ester
Article Data: 21
Molecular Structure:
Molecular Structure of 147489-06-3 ((4R,6S)-6-[(1E)-2-[2-Cyclopropyl-4-(4-fluorophenyl)-3-quinolinyl]ethenyl]-2,2-dimethyl-1,3-dioxane-4-acetic acid tert-butyl ester)
Formula: C32H36FNO4
Molecular Weight: 517.641
Synonyms: 1,3-Dioxane-4-aceticacid,6-[2-[2-cyclopropyl-4-(4-fluorophenyl)-3-quinolinyl]ethenyl]-2,2-dimethyl-,1,1-dimethylethyl ester, [4R-[4a,6a(E)]]-;(3R,5S,6E)-7-[2-cyclopropyl-4-(4-fluorophenyl)-3-quinolyl]-2,2-Dimethyl-1,3-dioxane-6-heptenoic acid,1,1-dimethylethyl ester;
EINECS: 1592732-453-0
Density: 1.184 g/cm3
Melting Point: 105-116 °C(Solv: hexane (110-54-3))
Boiling Point: 604.559 °C at 760 mmHg
Flash Point: 319.426 °C
Appearance: white or almost white power
PSA: 57.65000
LogP: 7.57350
Related products
Synthetic route

C21H28N2O6S2

121660-37-5

2-cyclopropyl-4-(4-fluorophenyl)-3-formylquinoline

147489-06-3

(4R,6S)-(E)-{6-[2-(2-cyclopropyl-4-(4-fluorophenyl)quinolin-3-yl)-vinyl]-2,2-dimethyl-1,3-dioxan-4-yl}acetic acid tert-butyl ester

Conditions
ConditionsYield
With sodium t-butanolate In tetrahydrofuran at -10 - 25℃; for 4h;89.6%

C15H24N2O6S2

121660-37-5

2-cyclopropyl-4-(4-fluorophenyl)-3-formylquinoline

147489-06-3

(4R,6S)-(E)-{6-[2-(2-cyclopropyl-4-(4-fluorophenyl)quinolin-3-yl)-vinyl]-2,2-dimethyl-1,3-dioxan-4-yl}acetic acid tert-butyl ester

Conditions
ConditionsYield
With sodium hydride In tetrahydrofuran; mineral oil at 0 - 25℃; for 4h;89.3%
124752-23-4

tert-butyl 2-[(4R,6S)-6-formyl-2,2-dimethyl-1,3-dioxan-4-yl]acetate

154057-57-5

diethyl <2-cyclopropyl-4-(4-fluorophenyl)quinolin-3-yl>methylphosphonate

147489-06-3

(4R,6S)-(E)-{6-[2-(2-cyclopropyl-4-(4-fluorophenyl)quinolin-3-yl)-vinyl]-2,2-dimethyl-1,3-dioxan-4-yl}acetic acid tert-butyl ester

Conditions
ConditionsYield
With lithium chloride In tetrahydrofuran at 0 - 35℃; for 5.66667h; Reagent/catalyst; Inert atmosphere;89%
With n-butyllithium In tetrahydrofuran at -80 - -10℃; for 1h; Solvent; Temperature; Inert atmosphere;71%

C16H26N2O6S2

121660-37-5

2-cyclopropyl-4-(4-fluorophenyl)-3-formylquinoline

147489-06-3

(4R,6S)-(E)-{6-[2-(2-cyclopropyl-4-(4-fluorophenyl)quinolin-3-yl)-vinyl]-2,2-dimethyl-1,3-dioxan-4-yl}acetic acid tert-butyl ester

Conditions
ConditionsYield
With sodium hydride In tetrahydrofuran; mineral oil at 0 - 25℃; for 4h; Temperature;88.3%
1234331-54-4

2-({[2-cyclopropyl-4-(4-fluorophenyl)quinolin-3-yl]methyl}sulfonyl)benzo[d]thiazole

124752-23-4

tert-butyl 2-[(4R,6S)-6-formyl-2,2-dimethyl-1,3-dioxan-4-yl]acetate

147489-06-3

(4R,6S)-(E)-{6-[2-(2-cyclopropyl-4-(4-fluorophenyl)quinolin-3-yl)-vinyl]-2,2-dimethyl-1,3-dioxan-4-yl}acetic acid tert-butyl ester

Conditions
ConditionsYield
With potassium tert-butylate In tetrahydrofuran at -30 - 20℃; Product distribution / selectivity;86%

C18H28N2O6S2

121660-37-5

2-cyclopropyl-4-(4-fluorophenyl)-3-formylquinoline

147489-06-3

(4R,6S)-(E)-{6-[2-(2-cyclopropyl-4-(4-fluorophenyl)quinolin-3-yl)-vinyl]-2,2-dimethyl-1,3-dioxan-4-yl}acetic acid tert-butyl ester

Conditions
ConditionsYield
With sodium hydride In tetrahydrofuran; mineral oil at 0 - 25℃; for 4h;82.5%

((2-cyclopropyl-4-(4-fluorophenyl)quinolin-3-yl)methyl)triphenylphosphoniumchloride

124752-23-4

tert-butyl 2-[(4R,6S)-6-formyl-2,2-dimethyl-1,3-dioxan-4-yl]acetate

147489-06-3

(4R,6S)-(E)-{6-[2-(2-cyclopropyl-4-(4-fluorophenyl)quinolin-3-yl)-vinyl]-2,2-dimethyl-1,3-dioxan-4-yl}acetic acid tert-butyl ester

Conditions
ConditionsYield
With potassium carbonate In dimethyl sulfoxide at 30 - 50℃; for 3h; Large scale;80.2%
153968-97-9

2-cyclopropyl-4-(4-fluorophenyl)-3-iodoquinoline

153968-91-3

t-butyl (3R,5S,6E)-3,5-isopropylidenedioxy-7-chlorodimethylsilyl-6-heptenoate

147489-06-3

(4R,6S)-(E)-{6-[2-(2-cyclopropyl-4-(4-fluorophenyl)quinolin-3-yl)-vinyl]-2,2-dimethyl-1,3-dioxan-4-yl}acetic acid tert-butyl ester

Conditions
ConditionsYield
With bis(η3-allyl-μ-chloropalladium(II)); tetrabutyl ammonium fluoride In tetrahydrofuran at 60℃; for 0.5h;80%

C31H38O4P(1+)*Cl(1-)

121660-37-5

2-cyclopropyl-4-(4-fluorophenyl)-3-formylquinoline

147489-06-3

(4R,6S)-(E)-{6-[2-(2-cyclopropyl-4-(4-fluorophenyl)quinolin-3-yl)-vinyl]-2,2-dimethyl-1,3-dioxan-4-yl}acetic acid tert-butyl ester

Conditions
ConditionsYield
With sodium carbonate In N,N-dimethyl-formamide at 80 - 85℃; for 1h; Temperature; Reagent/catalyst; Solvent; Inert atmosphere;79.2%
124752-23-4

tert-butyl 2-[(4R,6S)-6-formyl-2,2-dimethyl-1,3-dioxan-4-yl]acetate

<2-cyclopropyl-4-(4-fluorophenyl)quinolin-3-yl>methyltriphenylphosphonium bromide

147489-06-3

(4R,6S)-(E)-{6-[2-(2-cyclopropyl-4-(4-fluorophenyl)quinolin-3-yl)-vinyl]-2,2-dimethyl-1,3-dioxan-4-yl}acetic acid tert-butyl ester

Conditions
ConditionsYield
Stage #1: tert-butyl 2-[(4R,6S)-6-formyl-2,2-dimethyl-1,3-dioxan-4-yl]acetate; <2-cyclopropyl-4-(4-fluorophenyl)quinolin-3-yl>methyltriphenylphosphonium bromide In dimethyl sulfoxide at 35℃; Large scale;
Stage #2: With potassium carbonate In dimethyl sulfoxide at 70℃; for 4h; Solvent; Time; Temperature; Large scale;		72.3%
With potassium carbonate In dimethyl sulfoxide at 70℃; for 3h; Inert atmosphere;55.8%
With potassium carbonate In dimethyl sulfoxide at 70℃; for 3h; Wittig Reaction;
Hot Products
  • Display:default sort

    New supplier

  • 2-Cyclopropyl-4-(4-fluorophenyl)quinoline-3-carboxaldehyde

  • Casno:

    147489-06-3

    2-Cyclopropyl-4-(4-fluorophenyl)quinoline-3-carboxaldehyde

    Min.Order: 25 Kilogram

    FOB Price:  USD $ 0.0-0.0

    The company serves as a key global supplier of statins intermediates, which has a solid industrial foundation in the field of statins for lipid-lowering drugs, and holds a leading position in the market. Leveraging extensive experience in research an

    Hunan Wistar Imp. & Exp Company is headquartered in the Ecological Chemical Technology Industrial Park of Suqian City, Jiangsu Province. It is the largest pharmaceutical company i

  •  Hunan Wistar Imp. & Exp. Co., Ltd.

     China (Mainland)  |  Contact Details

    Business Type:Trading Company

    Tel:0527-84829968

    Address:No. 5 Yanshan Road, Suqian Ecological Chemical Technology Industrial Park, Jiangsu Province

       Inquiry Now

  • Pharmaceutical Grade CAS 147489-06-3 with competitive price

  • Casno:

    147489-06-3

    Pharmaceutical Grade CAS 147489-06-3 with competitive price

    Min.Order: 1 Kilogram

    FOB Price:  USD $ 139.0-210.0

    WITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et

    Zhuo Zhou Wen Xi Import and Export Co., Ltd. is a company mainly engaged in the export of pharmaceutical raw materials. Its parent company is （Wen Xi Pharma）, including three subs

  •  Zhuozhou Wenxi import and Export Co., Ltd

     China (Mainland)  |  Contact Details

    Business Type:Trading Company

    Tel:+86-13111626072

    Address:Room 1710, Baoxin International Phase I, 19 Guanyun East Road, Zhuozhou, Hebei

       Inquiry Now

  • high quality 147489-06-3 Pitavastatin Impurity 15 with best price

  • Casno:

    147489-06-3

    high quality 147489-06-3 Pitavastatin Impurity 15 with best price

    Min.Order: 10 Gram

    FOB Price:  USD $ 0.0-0.0

    1. Guaranteed purity; 2. Large quantity in stock; 3. Largest manufacturer; 4. Best service after shipment with email; 5. High quality & competitive price; Appearance:White Crystalline Powder Storage:Store in sealed conta

    Hubei Xinrunde Chemical Co., Ltd. dedicated to the development, production and marketing of chemicals which is specialized in Organic compounds; Active Pharmaceutical Ingredient(s)

  •  Hubei Langyou International Trading Co., Ltd

    China (Mainland)  |  Contact Details

    Business Type:Other

    Tel:+8618874586545

    Address:No.43, Xinandu Industrial Park, East and West Lake District, Wuhan, Hubei, China

       Inquiry Now

  • Pitavastatin intermediate PB4/147489-06-3

  • Casno:

    147489-06-3

    Pitavastatin intermediate PB4/147489-06-3

    Min.Order: 1 Kilogram

    FOB Price:  USD $ 18.0-20.0

    factory?direct?saleAppearance:White Powder Storage:Store In Dry, Cool And Ventilated Place Package:25kg/drum, also according to the clients requirement Application:It is widely used as a thickener, emulsifier and stabilizer Transportation:By Sea Or B

    Founded in 2008, East Chemsources Limited is a professional manufacturer of supplier in food and beverage, pharmaceuticals, cosmetics and other industries. pharmaceutical field in

  •  EAST CHEMSOURCES LIMITED

     China (Mainland)  |  Contact Details

    Business Type:Trading Company

    Tel:15053231572

    Address:No.1581-12,Jinshui Road, Licang, Qingdao,China

       Inquiry Now

  • Pitavastatin intermediate PB4/147489-06-3

  • Casno:

    147489-06-3

    Pitavastatin intermediate PB4/147489-06-3

    Min.Order: 1 Metric Ton

    FOB Price:  USD $ 1.5-1.5

    1.Applied in food field.it can improve the immune system and prolong life. 2.Appliedin cosmetic field.it can improve the skin care. 3.Applied in pharmaceutical field.it can treat various dieases. 4.Our product quality assurance will make our customer

    KAISA GROUP INC.is the enterprise which is specialize in manfacturing and exporting avariety of Chemical in China. We have the strong economic base and comprehensive technology.We

  •  KAISA GROUP INC

    United States  |  Contact Details

    Business Type:Trading Company

    Tel:15131197030

    Address:1312 17th Street Suite 1402 Denver CO 80202

       Inquiry Now

  • Pitavastatin Calcium N-2 (147489-06-3 )

  • Casno:

    147489-06-3

    Pitavastatin Calcium N-2 (147489-06-3 )

    Min.Order: 500 Gram

    FOB Price:  USD $ 0.0-0.0

    high purity Application:Cardiovascular

    Senova Tech is a leading supplier for APIs (mainly for new generics), advanced intermediates and related products based in China, our headquarter office locates in Shenzhen (a city

  •  Senova Technology Company Limited

     China (Mainland)  |  Contact Details

    Business Type:Trading Company

    Tel:+86-755-86703119

    Address:309# in Building 3 of North Area, Dayuan Industry Park, Xili, Nanshan District of Shenzhen

       Inquiry Now

Post a RFQ

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

1

What can I do for you?
Get Best Price

Get Best Price for 147489-06-3

Chemistry

Molecular structure of (4R,6S)-6-[(1E)-2-[2-Cyclopropyl-4-(4-fluorophenyl)-3-quinolinyl]ethenyl]-2,2-dimethyl-1,3-dioxane-4-acetic acid tert-butyl ester (CAS NO.147489-06-3) is:

Product Name: (4R,6S)-6-[(1E)-2-[2-Cyclopropyl-4-(4-fluorophenyl)-3-quinolinyl]ethenyl]-2,2-dimethyl-1,3-dioxane-4-acetic acid tert-butyl ester
CAS Registry Number: 147489-06-3
Molecular Formula: C32H36FNO4
Molecular Weight: 517.64

Specification

 (4R,6S)-6-[(1E)-2-[2-Cyclopropyl-4-(4-fluorophenyl)-3-quinolinyl]ethenyl]-2,2-dimethyl-1,3-dioxane-4-acetic acid tert-butyl ester , its cas register number is 147489-06-3. It also can be called 1,3-Dioxane-4-aceticacid,6-[(1E)-2-[2-cyclopropyl-4-(4-fluorophenyl)-3-quinolinyl]ethenyl]-2,2-dimethyl-,1,1-dimethylethyl ester, (4R,6S)- ; (3R,5S,6E)-7-[2-cyclopropyl-4-(4-fluorophenyl)-3-quinolyl]-2,2-Dimethyl-1,3-dioxane-6-heptenoic acid,1,1-dimethylethyl ester .