CAS No.147511-69-1,Pitavastatin Suppliers

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Basic Information

Molecular Structure:
CAS No.:	147511-69-1
Name:	Pitavastatin
Article Data:	16

Formula:	C₂₅H₂₄FNO₄
Molecular Weight:	421.468
Synonyms:	6-Heptenoicacid, 7-[2-cyclopropyl-4-(4-fluorophenyl)-3-quinolinyl]-3,5-dihydroxy-,[S-[R,S-(E)]]-;(+)-(3R,5S,6E)-7-[2-Cyclopropyl-4-(4-fluorophenyl)-3-quinolyl]-3,5-dihydroxy-6-heptenoicacid;(3R,5S,6E)-7-[2-Cyclopropyl-4-(4-fluorophenyl)quinolin-3-yl]-3,5-dihydroxyhept-6-enoicacid;NK 104;
Density:	1.352 g/cm³
Boiling Point:	691.961 °C at 760 mmHg
Flash Point:	372.285 °C
PSA:	90.65000
LogP:	4.51810

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Specification

This chemical is called Pitavastatin, and its IUPAC name is (E,3R,5S)-7-[2-cyclopropyl-4-(4-fluorophenyl)quinolin-3-yl]-3,5-dihydroxyhept-6-enoic acid. With the molecular formula of C₂₅H₂₄FNO₄, its molecular weight is 421.46. The CAS registry number of this chemical is 147511-69-1, and its classification codes are Antihyperlipidemic; Enzyme Inhibitors.

Other characteristics of the Pitavastatin can be summarised as followings: (1)ACD/LogP: 3.34; (2)# of Rule of 5 Violations: 0; (3)ACD/LogD (pH 5.5): 1.92; (4)ACD/LogD (pH 7.4): 0.22; (5)ACD/BCF (pH 5.5): 7.79; (6)ACD/BCF (pH 7.4): 1; (7)ACD/KOC (pH 5.5): 59.84; (8)ACD/KOC (pH 7.4): 1.18; (9)#H bond acceptors: 5; (10)#H bond donors: 3; (11)#Freely Rotating Bonds: 10; (12)Polar Surface Area: 57.65 Å²; (13)Index of Refraction: 1.679; (14)Molar Refractivity: 117.77 cm³; (15)Molar Volume: 311.6 cm³; (16)Polarizability: 46.68×10^-24cm³; (17)Surface Tension: 64.7 dyne/cm; (18)Density: 1.352 g/cm³; (19)Flash Point: 372.3 °C; (20)Enthalpy of Vaporization: 106.48 kJ/mol; (21)Boiling Point: 692 °C at 760 mmHg; (22)Vapour Pressure: 4.21E-20 mmHg at 25°C.

Uses of this chemical: Like the other statins, pitavastatin is indicated for hypercholesterolaemia (elevated cholesterol) and for the prevention of cardiovascular disease. It can consistently increase HDL cholesterol (10–25%), especially in patients with HDL lower than 40 mg/dl. As a consequence, this chemical is most likely to be appropriate for patients with metabolic syndrome with high LDL, low HDL and diabetes mellitus.

This chemical may cause the side-effects like headaches, stomach upset, abnormal liver function tests and muscle cramps. However, it seems to lead to less muscle side effects than other statins.

You can still convert the following datas into molecular structure:
1.SMILES: O=C(O)CC(O)CC(O)/C=C/c1c(c3ccccc3nc1C2CC2)c4ccc(F)cc4
2.InChI: InChI=1/C25H24FNO4/c26-17-9-7-15(8-10-17)24-20-3-1-2-4-22(20)27-25(16-5-6-16)21(24)12-11-18(28)13-19(29)14-23(30)31/h1-4,7-12,16,18-19,28-29H,5-6,13-14H2,(H,30,31)/b12-11+
3.InChIKey: VGYFMXBACGZSIL-VAWYXSNFBA