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Detail of "14769-73-4"

  • CAS Number:
  • 14769-73-4
  • Name:

  • Imidazo[2,1-b]thiazole,2,3,5,6-tetrahydro-6-phenyl-, (6S)-

  • Superlist Name:
  • Levamisole
  • Molecular Structure:
  • Formula:
  • C11H12N2S
  • Molecular Weight:
  • 204.29
  • Deleted CAS:
  • 53096-13-2
  • Synonyms:
  • (-)-Tetramisole;(S)-(-)-Levamisole;Ketrax;L-Tetramisole;Lepuron;Levamisol;Levipor;Levomysol;Levovermax;Totalon;Vermisol 150;Wormicid;l-2,3,5,6-Tetrahydro-6-phenylimidazo[2,1-b]thiazole;Imidazo[2,1-b]thiazole,2,3,5,6-tetrahydro-6-phenyl-, (S)-;(-)-2,3,5,6-Tetrahydro-6-phenylimidazo[2.1-b]thiazole;
  • EINECS:
  • 238-836-5
  • Density:
  • 1.32 g/cm3
  • Boiling Point:
  • 344.4 °C at 760 mmHg
  • Flash Point:
  • 162.1 °C
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CAS No.14769-73-4 Levamisole

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Molecular Formula: C11H12N2S Quality standards:USP31

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Reference

Parasiticidal formulations
Parasiticidal formulations. Galbraith, Andrew R.; Ballany, John M. (Janssen Pharmaceutica N. V., Belg.). Brit. UK Pat. Appl. GB 2148119 A1 30 May 1985, 9 pp. (English). (United Kingdom). CODEN: BAXXDU. CLASS: ICM: A01N053-00. ICS: A01N043-90. APPLICATION: GB 84-23263 14 Sep 1984. PRIORITY: GB 83-27761 17 Oct 1983. DOCUMENT TYPE: Patent CA Section: 5 (Agrochemical Bioregulators) Compns. contg. levamisole [14769-73-4] and (or) tetramisole [5036-02-2], pyrethroids, optionally substituted carboxylic acids (pKa = 0.6-6.0), and a solvent are stable pour-on parasiticide formulations for the control of ecto- and endoparasites of cattle and sheep. Thus, a formulation comprised of levamisole 10, deltamethrin [52918-63-5] 2, citric acid [77-92-9] 20, acetic acid [64-19-7] 10 g with the balance to 100 mL 2-(2-butoxyethoxy)ethanol [112-34-5] was stable for 36 mo.
Levamisole circumvents inhibition of lymphocyte activation imposed by uremic serum
Levamisole circumvents inhibition of lymphocyte activation imposed by uremic serum. Modai, D.; Weissgarten, J.; Shaked, U.; Segal, S.; Pik, A.; Fuchs, R. (Inst. Nephrol. Med. Dep. A, Assaf Harofeh Med. Cent., Zerifin 70300, Israel). Nephron, 40(4), 436-9 (English) 1985. CODEN: NPRNAY. ISSN: 0028-2766. DOCUMENT TYPE: Journal CA Section: 1 (Pharmacology) Uremic serum inhibits thymidine incorporation of phytohemagglutinin-stimulated lymphocytes originating in normal individuals. In this study the effect of levamisole [14769-73-4] on such inhibition was investigated. Preincubation with a wide range of levamisole concns. resulted in complete prevention of the inhibitory effect imposed by uremic serum on thymidine incorporation. Apparently, uremic serum possibly inhibits thymidine incorporation of normal lymphocytes by imposing an abnormal cGMP/cAMP intracellular ratio, and levamisole may restore this ratio to normal.
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