Detail of "1477-57-2"

CAS Number:
1477-57-2
Name:
Acetamide,N,N'-1,8-octanediylbis[2,2-dichloro-
Molecular Structure:
Formula:
C12H20 Cl4 N2 O2
Molecular Weight:
366.14
Synonyms:
Acetamide,N,N'-octamethylenebis[2,2-dichloro- (6CI,7CI,8CI); Bis-Diamine; Fertilysin;Fertilysine; N,N'-Bis(dichloroacetyl)-1,8-diaminooctane;N,N'-Bis(dichloroacetyl)-1,8-octamethylenediamine;N,N'-Octamethylenebis(2,2-dichloroacetamide); NSC 59354; Win 18441; Win 18446
Density:
1.285g/cm³
Melting Point:
118-120 °C
Boiling Point:
530.2°Cat760mmHg
Flash Point:
274.5°C
Safety:
Poison by intraperitoneal route. Human systemic effects by ingestion: nausea and vomiting. Human reproductive effects by ingestion: changes in spermatogenesis. An experimental teratogen. Other experimental reproductive effects. Human mutation data reported. When heated to decomposition it emits very toxic fumes of Cl⁻ and NO_x. Details

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N,N'-Octamethylenebis(dichloroacetamide)

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Thymic hypoplasia due to a bis-diamine: Thymic hypoplasia due to a bis-diamine. Matsuo, Takeshi; Ikeda, Takayoshi (Sch. Med., Nagassaki Univ., Nagasaki 852, Japan). Senten Ijo, 24(1), 47-54 (English) 1984. CODEN: SEIJAN. ISSN: 0037-2285. DOCUMENT TYPE: Journal CA Section: 4 (Toxicology) Rats were given 200 mg/day of N,N'-bis(dichloroacetyl-1,8-octamethylenediamine (bis-diamine) [1477-57-2] via a gastric tube on gestation days 9, 10, and 11. The fetuses of 14, 16, 18, and 20 days and newborn rats were examd. using light and electron microscopes as well as rat T-cell surface markers. The thymus rudiment in rats treated with bis-diamine was compared to the normal at each stage. A high incidence of aplasia or hypoplasia of the thymus was obsd. in treated groups. Histol. studies revealed a short delay in the appearance of lymphocytic cells in the thymus, which initially were blastlike and later small lymphocytes, and also a delay in cortical and medullary differentiation of the thymus. Immunohistol. studies using anti-rat T-cell monoclonal antibodies confirmed the histol. findings which show a delay of the development of the thymus. Bis-diamine-induced anomalies were similar to those of the human primary immunodeficiency syndrome, particularly the DiGeorge syndrome.

Pathogenesis of persistent truncus arteriosus produced by bis-diamine in rats: Pathogenesis of persistent truncus arteriosus produced by bis-diamine in rats. Okishima, Takahiro; Odo, Shozo; Hayakawa, Kunio (Dep. Pediatr., Miyazaki Med. Coll., Miyazaki 889-16, Japan). Acta Paediatr. Jpn., Overseas Ed., 28(3), 403-18 (English) 1986. CODEN: APDJBE. ISSN: 0374-5600. DOCUMENT TYPE: Journal CA Section: 4 (Toxicology) The influence of bis-diamine [1477-57-2] on truncoconal septation was studied by the administration of 200 mg of this chem. to pregnant Donryu-strain rats on day 10 of gestation. Fetuses were removed at 9 time periods from day 11-15. Some hearts were obsd. under a scanning electron microscope; others were serially sectioned and obsd. by light microscopy. In the treated group, the aorticopulmonary septum and the 6th aortic arch artery were hypoplastic or aplastic. Truncal swelling and conal ridges showed hypoplasia and failure to fuse. Various types of persistent truncus arteriosus were found in assocn. with the degree of development of the 6th aortic arch artery and the aorticopulmonary septum. Fused 6th aortic arch arteries corresponding to Collett and Edwards' persistent truncus arteriosus type II, and nonfused arteries to type III. Aplastic arteries belonged to type IV or were unclassifiable.