Detail of "14774-37-9"

CAS Number:
14774-37-9
Name:
(Tetrahydro-2H-pyran-4-yl)methanol
Superlist Name:
4-(Hydroxymethyl)tetrahydropyran
Molecular Structure:
Formula:
C₆H₁₂O₂
Molecular Weight:
116.16
Synonyms:
2H-Pyran-4-methanol,tetrahydro-;(Tetrahydropyran-4-yl)methanol;4-(Hydroxymethyl)tetrahydro-2H-pyran;Tetrahydropyran-4-methanol;(Tetrahydro-pyran-4-yl)-methanol;
Density:
1 g/cm³
Boiling Point:
218.9 °C at 760 mmHg
Flash Point:
97.7 °C
Hazard Symbols:
Xn,Xi
Risk Codes:
36/37/38-22
Safety:
26-36/37/39-23 Details

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Reference

A preparation of pyrimidine derivatives, useful as ghrelin receptor modulators: A preparation of pyrimidine derivatives, useful as ghrelin receptor modulators. Kosogof, Christi; Liu, Bo; Liu, Gang; Liu, Mei; Nelson, Lissa T. j.; Serby, Michael D.; Sham, Hing L.; Szczepankiewicz, Bruce G.; Xin, Zhili; Zhao, Hongyu (USA ). U.S. Pat. Appl. Publ. US 2005070712 A1 31 Mar 2005,50 pp. (English). (United States of America). CODEN: USXXCO. CLASS: ICM: A61K031-513. ICS: C07D043-04. APPLICATION: US 2003-671723 26 Sep 2003. DOCUMENT TYPE: Patent CA Section: 28 (Heterocyclic Compounds (More Than One Hetero Atom)) Section cross-reference(s): 1, 63 The invention relates to a prepn. of pyrimidine derivs. of formula I [wherein: R1 is H, (cyclo)alkyl, aryl, CN, or haloalkyl, etc.; R2 is H, alkyl, alkoxy, aryl, halogen, or haloalkyl, etc.; R3 is alkenyl, alkenyloxy, alkynyloxy, heteroarylthio, or arylthio, etc.; R4 is alkenyl, alkenyloxy, alkoxyalkyl, alkyl, or alkylthio, etc.; R5, R6, R7, and R8 are independently selected from H, alkenyl, alkyl, cyanoalkyl, alkylcarbonyl, or alkoxysulfonyl, etc.; A is (hetero)aryl, cycloalkyl, cycloalkenyl, or heterocycle], useful as ghrelin receptor modulators. The invention compds. 14774-37-9 is the cas registry number of certain chemical which is used as reagents here. are useful in the prevention or treatment of disorders regulated by ghrelin receptor (anorexia, cancer cachexia, eating disorders, obesity, and diabetes mellitus, etc.). For instance, pyrimidine deriv. II was prepd. via heterocyclization of 2-(4-nitrophenyl)-3-oxopentanenitrile with CH2N2, redn. of the obtained (nitrophenyl)pyrimidine deriv. III (R9 = NO2), and subsequent reductive amination of 4-chlorobenzaldehyde by the obtained (aminophenyl)pyrimidine deriv. III (R9 = NH2) (yields: heterocyclization - 27%, redn. - 90%, reductive amination - 29%). The preferred compds. stimulate ghrelin receptor with EC50 in a range of about 0.001 mM to about 0.1 mM. Other preferred compds. inhibit the activity of ghrelin receptor with IC50 in a range of about 0.001 mM to about 0.1 mM. .

Detail of "14774-37-9"

(Tetrahydro-2H-pyran-4-yl)methanol

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CAS No.14774-37-9 4-(Hydroxymethyl)tetrahydropyran

CAS No.14774-37-9 4-(Hydroxymethyl)tetrahydropyran

CAS No.14774-37-9 4-(Hydroxymethyl)tetrahydropyran

CAS No.14774-37-9 4-(Hydroxymethyl)tetrahydropyran

CAS No.14774-37-9 4-(Hydroxymethyl)tetrahydropyran

CAS No.14774-37-9 4-(Hydroxymethyl)tetrahydropyran

CAS No.14774-37-9 4-(Hydroxymethyl)tetrahydropyran

CAS No.14774-37-9 4-(Hydroxymethyl)tetrahydropyran

CAS No.14774-37-9 4-(Hydroxymethyl)tetrahydropyran

CAS No.14774-37-9 4-(Hydroxymethyl)tetrahydropyran

CAS No.14774-37-9 4-(Hydroxymethyl)tetrahydropyran

CAS No.14774-37-9 4-(Hydroxymethyl)tetrahydropyran

CAS No.14774-37-9 4-(Hydroxymethyl)tetrahydropyran

CAS No.14774-37-9 4-(Hydroxymethyl)tetrahydropyran

CAS No.14774-37-9 4-(Hydroxymethyl)tetrahydropyran

CAS No.14774-37-9 4-(Hydroxymethyl)tetrahydropyran

CAS No.14774-37-9 4-(Hydroxymethyl)tetrahydropyran

CAS No.14774-37-9 4-(Hydroxymethyl)tetrahydropyran

CAS No.14774-37-9 4-(Hydroxymethyl)tetrahydropyran

CAS No.14774-37-9 4-(Hydroxymethyl)tetrahydropyran

CAS No.14774-37-9 4-(Hydroxymethyl)tetrahydropyran

Reference