Reference

Teratogenic effects in cattle of Conium maculatum and Conium alkaloids, and analogs

Teratogenic effects in cattle of Conium maculatum and Conium alkaloids, and analogs. Keeler, Richard F.; Dell Balls, Lew (Poisonous Plant Res. Lab., ARS, Logan, Utah, USA). Clin. Toxicol., 12(1), 49-64 (English) 1978. CODEN: CTOXAO. DOCUMENT TYPE: Journal CA Section: 4 (Toxicology) The plant C. maculatum produced congenital defects in calves born to cows gavaged with the fresh green plant material during days 50-75 of gestation. Both arthrogryposis and spinal curvature were produced and were similar to the defects produced by the piperidine alkaloid coniine [458-88-8]. The arthrogrypotic manifestations markedly increased as the animals aged. Animals gavaged with dry plant had either normal or equivocally deformed offspring. When 7 structurally-related analogs were tested, only piperidine [110-89-4] and 2-piperidineethanol [1484-84-0] produced clin. signs of toxicity but none of the 7 analogs caused congenital deformities. No congenital defects arose in offspring from maternal inhalation of coniine or the green plant.

Mammalian target of rapamycin (mTOR) inhibitors and their use for treatment of cell proliferation-associated diseases and tumor

All Rights Reserved. Mammalian target of rapamycin (mTOR) inhibitors and their use for treatment of cell proliferation-associated diseases and tumor. Murakata, Isamu; Ino, Yoji; Atsumi, Toshiyuki; Yamashita, Koji; Takahashi, Hiroko; Asai, Akiyoshi (Kyowa Hakko Kogyo Co., Ltd., Japan). Jpn. Kokai Tokkyo Koho JP 2007022998 A 1 Feb 2007, 78pp. (Japanese). (Japan). CODEN: JKXXAF. APPLICATION: JP 2005-211122 21 Jul 2005. DOCUMENT TYPE: Patent CA Section: 28 (Heterocyclic Compounds (More Than One Hetero Atom)) Section cross-reference(s): 1, 63 Title inhibitors contain 4-aminoquinazolines I [R1, R2 = H, OH, halo, NO2, cyano, lower alkyl, lower alkylsulfonyloxy, (un)substituted aryl, (lower alkyl)amino, lower alkoxycarbonyl, CO2H, etc.Several substances like 1484-84-0 may be metioned in this study.; R1CCR2 may form O(CH2)mO; m = 1-3; R3 = H, (un)substituted lower alkyl; R4 = H, YR11; Y = bond, (un)substituted alkylene; R11 = H, OH, halo, lower alkoxy, (lower alkyl)amino, CO2H, (un)substituted aryl, (un)substituted arom. or aliph. heterocyclyl, etc.; R3NR4 may form (un)substituted heterocyclyl; R5 = (un)substituted aryl, (un)substituted arom. or aliph. heterocyclyl] or their pharmacol. acceptable salts as active ingredients. Thus, 4-chloro-6,7-dimethoxy-2-[2-(E)-(3,5-dimethoxyphenyl)vinyl]quinazoline was aminated with 4-(2-aminoethyl)pyridine to give I (R1 = 6-MeO, R2 = 7-MeO, R3 = H, R4 = 4-pyridylethyl, R5 = 3,5-dimethoxyphenyl), which inhibited mTOR in human HCT116 cells with GI50 value of <10 mmol/L. .