Detail of "1486-70-0"

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CAS Number:
1486-70-0
Name:
4H-1-Benzopyran-4-one,2-(3,4-dihydroxyphenyl)-5,7-dihydroxy-3-methoxy-
Molecular Structure:
Formula:
C16H12 O7
Molecular Weight:
316.26228
Synonyms:
Flavone,3',4',5,7-tetrahydroxy-3-methoxy- (7CI,8CI);3-Methoxy-3',4',5,7-tetrahydroxyflavone;3-Methoxy-5,7,3',4'-tetrahydroxyflavone; 3-Methylquercetin; 3-Methylquercetol;3-O-Methylquercetin; 3',4',5,7-Tetrahydroxy-3-methoxyflavone;5,7,3',4'-Tetrahydroxy-3-methoxyflavone; NSC 154016; Quercetin 3-methyl ether;Quercetin 3-monomethyl ether; Quercetin-3-O-methyl ether
Density:
1.69g/cm³
Boiling Point:
643°Cat760mmHg
Flash Point:
244.7°C

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Study on polyphenols from some Grindelia species: Study on polyphenols from some Grindelia species. Pinkas, M.; Didry, N.; Torck, M.; Bezanger, L.; Cazin, J. C. (Lab. Matiere Med. Pharmacodyn., Fac. Pharm., Lille, Fr.). Ann. Pharm. Fr., 36(3-4), 97-104 (French) 1978. CODEN: APFRAD. ISSN: 0003-4509. DOCUMENT TYPE: Journal CA Section: 63 (Pharmaceuticals) Section cross-reference(s): 3, 11 Nine phenolic acids and flavonoids were isolated from the medicinal plant G. squarrosa: p-hydroxybenzoic acid [99-96-7], vanillic acid [121-34-6], p-coumaric acid [7400-08-0], quercetol [117-39-5], luteolol [491-70-3], 3-methylquercetol [1486-70-0], 3-methylkaempferol [1592-70-7], 3,3'-dimethylquercetol [4382-17-6], and 3,7-dimethylkaempferol [3301-49-3]. Most of these compds. were also found in G. aphanactis, G. robusta, and G. maritima. Some constituents of the essential oil of G. squarrosa were identified, including terpineol [8000-41-7], a-pinene [80-56-8], and b-pinene [127-91-3]. A polyphenol-contg. ext. of G. squarrosa had antibacterial activity in vitro, antiinflammatory activity in rats, and weak antispasmodic action.

The poliovirus-induced shut-off of cellular protein synthesis persists in the presence of 3-methylquercetin, a flavonoid which blocks viral protein and RNA synthesis: The poliovirus-induced shut-off of cellular protein synthesis persists in the presence of 3-methylquercetin, a flavonoid which blocks viral protein and RNA synthesis. Vrijsen, R.; Everaert, L.; Van Hoof, L. M.; Vlietinck, A. J.; Vanden Berghe, D. A.; Boeye, A. (Dep. Microbiol. Hyg., Vrije Univ. Brussel, Brussels B-1090, Belg.). Antiviral Res., 7(1), 35-42 (English) 1987. CODEN: ARSRDR. ISSN: 0166-3542. DOCUMENT TYPE: Journal CA Section: 1 (Pharmacology) In poliovirus-infected cells, the viral protein and RNA synthesis were severely reduced, provided 3-methylquercetin [1486-70-0] was present between 1 and 2 h post-infection. Under these conditions, the virally-induced host shut-off remained in effect. On the other hand, in uninfected HeLa cells, protein and RNA synthesis was inhibited only slightly by 3-methylquercetin. The inhibition of poliovirus cytopathogenicity in Vero cells by 3-methylquercetin exhibited a similar time dependence.