Detail of "14861-17-7"

Reference

Further characterization of the distribution and metabolism of nitrofen in the pregnant rat

Further characterization of the distribution and metabolism of nitrofen in the pregnant rat. Brown, T. J.; Manson, J. M. (Dep. Reprod. Dev. Toxicol., Smith Kline and French Lab., Philadelphia, PA 19101, USA). Teratology, 34(2), 129-39 (English) 1986. CODEN: TJADAB. ISSN: 0040-3709. DOCUMENT TYPE: Journal CA Section: 4 (Toxicology) Nitrofen (I) [1836-75-5] (240 mg/kg) was administered intragastrically to rats on day 10 of pregnancy. Radioactivity was accumulated and retained in maternal fat for >72 h. Peak levels were reached in other maternal organs at 3-12 h. The half-life in maternal plasma was ~42 h. Radioactivity was 1st detected in the embryonic compartment at 3 h and continued to increase through the 72-h time point. I is initially deposited in maternal fat and after 48 h redistributes to other maternal organs and to the embryo. The 5-hydroxy deriv. [63987-04-2] was the major I metabolite found in maternal tissues, while the 4'-amino [14861-17-7] and 4'-acetylamino [56120-26-4], derivs. were found at lower levels and all exhibited single-phase kinetics. The parent compd. alone was found in the embryo, and levels increased gradually as I redistributed from the fat at 48 h after exposure. 1836-75-5 which is the cas registry number of one of substances is just one of reagents here. Apparently, I teratogenicity is not mediated by mutagenic intermediates through nitro group redn. of the parent compd. Rather, the embryo is exposed to the parent compd. alone and appears to be a deep compartment for accumulation of I. .

Absorption, excretion, and metabolism of nitrofen by a sheep

Absorption, excretion, and metabolism of nitrofen by a sheep. Hunt, LaWanda M.; Chamberlain, William F.; Gilbert, Bennye N.; Hopkins, Donald E.; Gingrich, Alan R. (Livest. Insects Lab., ARS, Kerrville, Tex., USA). J. Agric. Food Chem., 25(5), 1062-5 (English) 1977. CODEN: JAFCAU. DOCUMENT TYPE: Journal CA Section: 4 (Toxicology) Section cross-reference(s): 17 14C-labeled nitrofen (I) [1836-75-5] was administered orally to sheep at 40 mg/kg. Ninety-nine h after treatment, 76.2% of the applied dose was accounted for in the excreta. I was found in feces and blood, but not in urine. At the 100-h slaughter, radiocarbon levels were highest in fat (23.1-24.1 ppm); the liver, thyroid, and mammary gland had levels of 2-3 ppm; and the adrenal gland, kidney, lung, muscle, skin, and spleen had levels of 1-2 ppm. The most predominant metab. products were 2,4-dichlorophenyl 4-aminophenyl ether [14861-17-7], 2,4-dichloro-5-hydroxyphenyl 4-nitrophenyl ether [63987-04-2], 2,4-dichlorophenol [120-83-2], 2-chlorophenyl 4-nitrophenyl ether [2091-61-4], and conjugates. No evidence of rearrangement of the chlorines was seen.