Detail of "14868-03-2"

Reference

Dehydrochlorination method

Dehydrochlorination method. Kinson, Philip L.; Quinn, Clayton B. (General Electric Co., USA). U.S. US 4073814 14 Feb 1978, 8 pp. (English). (United States of America). CODEN: USXXAM. CLASS: IC: C07C037-00. NCL: 260619000A. APPLICATION: US 77-768209 14 Feb 1977. DOCUMENT TYPE: Patent CA Section: 36 (Plastics Manufacture and Processing) Section cross-reference(s): 25 1,1-Dichloro-2,2-bis(4-hydroxyphenyl)ethylene (I) [14868-03-2] was prepd. by dehydrochlorination of 1,1,1-trichloro-2,2-bis(4-hydroxyphenyl)ethane (II) [2971-36-0] in the presence of a basic alkali metal compd. and a dipolar aprotic solvent; I was copolymd. with Cl2CO to give an impact-resistant, fireproof polycarbonate. Thus, II 1816, Na2CO3 606.3, and DMF 11,470 parts were heated to 75-80°, bubbled with N for ~30 h, cooled, mixed with 16,100 parts H2O, and cooled to give 97% cryst. I. Cl2CO was bubbled at 0.52-1.63 parts/h through a mixt. of I 1, H2O 2.9-6.3, CH2Cl2 4.7-9, PhOH 0.008, Et3N 0.005-0.008, and Na gluconate 0.002 part to give a polycarbonate (III) [31546-39-1] of intrinsic viscosity ~0.52 dL/g (CH2Cl2, 25°). III was extruded and pelletized and the pellets were molded into test specimens having Izod notched impact strength 15 ft-lb./in.

Metabolic activation of pesticides with proestrogenic activity

Metabolic activation of pesticides with proestrogenic activity.Some chemicals with cas registry numbers like 2132-70-9 and 2971-36-0 are also used. Kupfer, David; Bulger, William H. (Worcester Found. Exp. Biol., Shrewsbury, MA 01545, USA). Fed. Proc., 46(5), 1864-9 (English) 1987. CODEN: FEPRA7. ISSN: 0014-9446. DOCUMENT TYPE: Journal CA Section: 4 (Toxicology) The role of metab. in the estrogenic activity of chlorinated hydrocarbon pesticides was examd. Whether the estrogenic activity in tech. grade prepns. of the pesticide methoxychlor (I) [72-43-5] is due to I or to contaminants was also investigated. Identified compds. in tech. I were examd. by an in vitro method to det. whether they are estrogens or proestrogens. This method showed that purified I and 1,1-dichloro-2,2-bis(4-methoxyphenyl)ethene (MDDE) [2132-70-9], are proestrogens and that monohydroxymethoxychlor [28463-03-8] and monohydroxy-MDDE [75938-34-0] are estrogens. Thus, the estrogenic activity in tech. I is due to both I and contaminants. MDDE is an in vivo metabolite of I, and the mono- and bishydroxy [1,1,1-trichloro-2,2-bis(4-hydroxyphenyl)ethane [2971-36-0]] derivs. of I and MDDE are metabolites of I and MDDE, resp. These metabolites exhibited in vitro estrogenic activity in the following order of potency: bishydroxy-MDDE [14868-03-2] > bis-hydroxy I > mono-hydroxy-MDDE > mono-hydroxy I. A similar order of potency was obsd. in vivo, demonstrating that metabolites of I are potent estrogens. In addn. to phenolic products, hepatic monooxygenase [9038-14-6] metabolize I and MDDE to reactive intermediates that bind covalently to microsomal proteins. Further studies are needed to det. the factors controlling the 2 pathways of I metab. and det. whether covalent binding is assocd. with cellular and organ toxicity. .