Detail of "1491-59-4"

Reference

Pharmacological characterization of postjunctional a-adrenoceptors in isolated human omental arteries and veins

Pharmacological characterization of postjunctional a-adrenoceptors in isolated human omental arteries and veins. Steen, Stig; Skaerby, Tor V. C.; Norgren, Lars; Andersson, Karl Erik (Dep. Clin. Pharmacol., Univ. Lund, Lund, Swed.). Acta Physiol. Scand., 120(1), 109-16 (English) 1984. CODEN: APSCAX. ISSN: 0001-6772. DOCUMENT TYPE: Journal CA Section: 2 (Mammalian Hormones) The a-adrenoceptors in human omental arteries and veins were characterized and compared. In the arteries both prazosin and rauwolscine displaced the noradrenaline (NA) [51-41-2] concn.-response (cr) curve towards higher concns. without redn. of the max. Neither clonidine [4205-90-7], nor oxymetazoline [1491-59-4] had any consistent contractile effects. Phenylephrine [59-42-7] had a lower potency than NA, but a similar intrinsic activity. In the veins, both prazosin and rauwolscine displaced the NA cr curve towards higher concns., but also depressed the max. Clonidine and oxymetazoline contracted veins from 3 of 7 and 4 of 6 patients. NA was more potent than phenylephrine in these vessels, and there was no significant difference in intrinsic activity. Thus, in human omental arteries, the postjunctional a-adrenoceptors are mainly of the a1-type, even if a small population of a2-adrenoceptors cannot be excluded. In omental veins, there seems to be a functionally important population of postjunctional a2-adrenoceptors occurring together with a population of a1-adrenoceptors.

In vivo study of pial venous reactions to norepinephrine

In vivo study of pial venous reactions to norepinephrine. Kuschinsky, W.; Ulrich, K.; Auer, L. M. (Dep. Physiol. 51-41-2 and 59-42-7 are cas registry numbers. These chemicals are also mentioned in this article., Univ. Munich, Munich, Fed. Rep. Ger.). Cereb. Veins, 155-9. Edited by: Auer, Ludwig M.; Loew, Friedrich. Springer: Vienna, Austria. (English) 1983. CODEN: 51CVA9. DOCUMENT TYPE: Conference CA Section: 2 (Mammalian Hormones) Perivascular microapplication of norepinephrine [51-41-2] (10-9-10-3M) caused constriction of pial veins in cats with the 10-3M concn. causing max. (22%) constriction. Both prazosin and yohimbine, added to the norepinephrine soln., dose-dependently decreased the constrictory n response to norepinephrine. a1-Adrenoceptor stimulation by phenylephrine [59-42-7] caused weak constriction of the pial veins, whereas a2-adrenoceptor stimulation by oxymetazoline [1491-59-4] had no consistent constrictory effect. Thus, the sympathetic adrenergic system may play a role in regulating cerebral venous tone. .