CAS No.14916-63-3,2-Amino-6-nitropyridine Suppliers

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Basic Information

Molecular Structure:
CAS No.:	14916-63-3
Name:	2-Amino-6-nitropyridine
Article Data:	1

Formula:	C₅H₅N₃O₂
Molecular Weight:	139.114
Synonyms:	Pyridine,2-amino-6-nitro- (8CI);6-Nitropyridin-2-amine;
EINECS:	1312995-182-4
Density:	1.437 g/cm³
Boiling Point:	368.05 °C at 760 mmHg
Flash Point:	176.39 °C
PSA:	84.73000
LogP:	1.67640

Synthetic route

: 2-Isocyanato-6-nitro-pyridine

: 14916-63-3
2-Amino-6-nitropyridine

Conditions

Conditions	Yield
With hydrogenchloride In benzene for 1h; Heating; Yield given;

: 14916-63-3
2-Amino-6-nitropyridine

: 79-04-9
chloroacetyl chloride

: 2-chloro-N-(2-(6-nitro)pyridinyl)acetamide

Conditions

Conditions	Yield
With triethylamine In tetrahydrofuran at 20℃;	91%

: 2398-37-0
3-methoxyphenyl bromide

: 14916-63-3
2-Amino-6-nitropyridine

: N-(3-methoxyphenyl)-6-nitropyridin-2-amine

Conditions

Conditions	Yield
Stage #1: 3-methoxyphenyl bromide With palladium diacetate; caesium carbonate; 4,5-bis(diphenylphos4,5-bis(diphenylphosphino)-9,9-dimethylxanthenephino)-9,9-dimethylxanthene In 1,4-dioxane at 75℃; for 0.333333h; Buchwald-Hartwig Coupling; Schlenk technique; Inert atmosphere; Stage #2: 2-Amino-6-nitropyridine In 1,4-dioxane at 105℃; for 0.5h; Inert atmosphere; Schlenk technique;	80%

: 88-88-0
2,4,6-trinitrochlorobenzene

: 14916-63-3
2-Amino-6-nitropyridine

: 1282032-14-7
6-nitro-2-picrylaminopyridine

Conditions

Conditions	Yield
In ethanol for 6h; Reflux;	76%

: 50-00-0
formaldehyd

: 14916-63-3
2-Amino-6-nitropyridine

: N-methyl-6-nitropyridin-2-amine

Conditions

Conditions	Yield
Stage #1: formaldehyd; 2-Amino-6-nitropyridine With sodium methylate In methanol at 50℃; for 16h; Stage #2: With methanol; sodium tetrahydroborate at 50℃; for 16h;	45%

: 405175-13-5
4-((pyrimidin-2-ylamino)methyl)benzaldehyde

: 14916-63-3
2-Amino-6-nitropyridine

: N-(4-(((6-nitropyridin-2-yl)amino)methyl)benzyl)pyrimidin-2-amine

Conditions

Conditions	Yield
With sodium tris(acetoxy)borohydride; acetic acid In 1,2-dichloro-ethane at 20℃; for 72h; Molecular sieve;	17%

: 14916-63-3
2-Amino-6-nitropyridine

: 1-(2-methoxyphenyl)-4-(2-(2-(5-fluoro)aminopyridinyl)ethyl)piperazine

: 1-(2-methoxyphenyl)-4-(2-(2-(6-nitro)aminopyridinyl)ethyl)piperazine

Conditions

Conditions	Yield
With triethylamine In acetonitrile Heating;	10%

: 14916-63-3
2-Amino-6-nitropyridine

: 2-[4-(2-methoxy-phenyl)-piperazin-1-yl]-N-(6-nitro-pyridin-2-yl)-acetamide

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: 91 percent / Et3N / tetrahydrofuran / 20 °C 2: 89 percent / K2CO3 / dimethylformamide / 5 h / 60 °C View Scheme

: 14916-63-3
2-Amino-6-nitropyridine

: 94166-64-0
2-nitro-6-chloro-pyridine

Conditions

Conditions	Yield
With tert.-butylnitrite; copper dichloride In tetrahydrofuran at 65℃; for 1h;

: 14916-63-3
2-Amino-6-nitropyridine

: 1211333-18-4
5-bromo-6-nitro-pyridin-2-ylamine

Conditions

Conditions	Yield
With N-Bromosuccinimide In acetonitrile at 0 - 20℃; Product distribution / selectivity; Inert atmosphere; Darkness;

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Specification

The 2-Amino-6-nitropyridine, with the cas registry number 14916-63-3, has the systematic name of 6-nitropyridin-2-amine. It belongs to the product categories of Nitro and Pyridines. And the molecular formula of the chemical is C₅H₅N₃O₂.

The characteristics of this chemical are as followings: (1)ACD/LogP: 1.11; (2)# of Rule of 5 Violations: 0; (3)ACD/LogD (pH 5.5): 1.11; (4)ACD/LogD (pH 7.4): 1.11; (5)ACD/BCF (pH 5.5): 4.14; (6)ACD/BCF (pH 7.4): 4.14; (7)ACD/KOC (pH 5.5): 96.2; (8)ACD/KOC (pH 7.4): 96.2; (9)#H bond acceptors: 5; (10)#H bond donors: 2; (11)#Freely Rotating Bonds: 1; (12)Polar Surface Area: 61.95 Å²; (13)Index of Refraction: 1.645; (14)Molar Refractivity: 35.12 cm³; (15)Molar Volume: 96.7 cm³; (16)Polarizability: 13.92×10^-24cm³; (17)Surface Tension: 72.8 dyne/cm; (18)Density: 1.437 g/cm³; (19)Flash Point: 176.4 °C; (20)Enthalpy of Vaporization: 61.47 kJ/mol; (21)Boiling Point: 368 °C at 760 mmHg; (22)Vapour Pressure: 1.31E-05 mmHg at 25°C.

Addtionally, the following datas could be converted into the molecular structure:
(1)SMILES: O=[N+]([O-])c1nc(N)ccc1
(2)InChI: InChI=1/C5H5N3O2/c6-4-2-1-3-5(7-4)8(9)10/h1-3H,(H2,6,7)
(3)InChIKey: JMAGBGSWLILKOC-UHFFFAOYAF