Detail of "14919-77-8"

CAS Number:
14919-77-8
Name:
Benserazide hydrochloride
Molecular Structure:
Formula:
C₁₀H₁₅N₃O₅^.HCl
Molecular Weight:
293.74
Deleted CAS:
14046-64-1|31796-68-6
Synonyms:
Serine,2-[(2,3,4-trihydroxyphenyl)methyl]- hydrazide,monohydrochloride;Ro 4-4602;Benserazide HCl;Serinehydrazide hydrochloride;Benserazide hydrochloride 98.5%;2'-(2,3,4-trihydroxybenzyl)-DL-serinohydrazide monohydrochloride;
EINECS:
238-991-9
Melting Point:
146 °C
Boiling Point:
574.2 °C at 760 mmHg
Flash Point:
301 °C
Appearance:
white crystalline solid
Hazard Symbols:
Xi
Risk Codes:
36/37/38
Safety:
26-36 Details

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Reference

Pharmacological studies on L-DOPA and DOPA decarboxylase inhibitors: Pharmacological studies on L-DOPA and DOPA decarboxylase inhibitors. Effect on the central nervous system with a combination of L-DOPA and benserazide hydrochloride. Takahashi, Noriyuki (Dep. Pharmacol., Tokyo Med. Coll., Tokyo, Japan). Tokyo Ika Daigaku Zasshi, 35(4), 715-30 (Japanese) 1977. CODEN: TIDZAH. DOCUMENT TYPE: Journal CA Section: 1 (Pharmacodynamics) L-Dopa [59-92-7] and a dopa decarboxylase inhibitor, benserazide-HCl (I-HCl) [14919-77-8], in combination (500 and 200 mg/kg, resp.,) administered orally to monkeys induced abnormal behavior, although the administration of each compd. alone was without effect. The combination of dopa and I (100 and 25 mg/kg, orally) given to rats decreased body temp. and 200 and 50 mg/kg, resp., markedly increased dopamine [51-61-6] level in the brain, suggesting that the dose of dopa for the treatment of parkinsonism may be reduced if it is combined with I.

Pineal aryl acylamidase: effects of melatonin, serotonin-related compounds, B-carbolines, RO4-4602 and antidepressants: Pineal aryl acylamidase: effects of melatonin, serotonin-related compounds, B-carbolines, RO4-4602 and antidepressants. Hsu, Louise L. (Dep. Psychiatry Behav. Sci., Univ. Texas, Galveston, TX 77550, USA). 14919-77-8 and 51-41-2 are also occured in this study. Res. Commun. Chem. Pathol. Pharmacol., 43(2), 223-34 (English) 1984. CODEN: RCOCB8. ISSN: 0034-5164. DOCUMENT TYPE: Journal CA Section: 1 (Pharmacology) Section cross-reference(s): 2, 7 The pineal aryl acylamidase (AAA) [9025-18-7] activity has been demonstrated and characterized for the first time using ONAc as a substrate. The pineal AAA activity in the presence of 0.05% Triton X-100 was linear with protein concn. up to 1 mg and with incubation time up to 1 h. Both the rat and bovine pineal showed a pH optimum at 5.0. The in vitro and in vivo effects of several classes of drugs on the pineal AAA activity were examd. At 0.1 mM, 5-HT creatinine sulfate [971-74-4], N-acetyl-5HT [1210-83-9], melatonin [73-31-4], d-LSD [50-37-3], l-LSD [2126-78-5], methiothepin [20229-30-5], dopamine [51-61-6], chlorimipramine [303-49-1], imipramine [50-49-7], pargyline [555-57-7], tetrahydro-b-carboline (THBC) [16502-01-5], and harmaline [304-21-2] significantly inhibited the rat pineal AAA activity by 19-51%. N-acetyl-5-HT was the most potent in vitro inhibitor. However, at the same concn., norepinephrine [51-41-2], 6-MeO-harman [3589-72-8] and eserine [57-47-6] did not show any effect on the enzyme activity. Lineweaver-Burk plots indicated a competitive type of in vitro inhibition of the pineal AAA activity by melatonin. Acute s.c. injection of low doses (25-50 mg/kg) THBC, harmaline, desipramine [50-47-5], and protryptyline [438-60-8] markedly inhibited the rat pineal AAA activity, but at higher doses (75-700 mg/kg) the inhibition was reduced. On the contrary, RO4-4602 [14919-77-8] (200-800 mg/kg) enhanced 1.5-2.3-fold the enzyme activity, inversely proportional to the doses given. In view of the differential effects of these drugs on brain AAA and pineal AAA, it seems unlikely that they would be the same enzyme. .

Detail of "14919-77-8"

Benserazide hydrochloride

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CAS No.14919-77-8 Benserazide hydrochloride

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CAS No.14919-77-8 Benserazide hydrochloride

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CAS No.14919-77-8 Benserazide hydrochloride

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CAS No.14919-77-8 Benserazide hydrochloride

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CAS No.14919-77-8 Benserazide hydrochloride

CAS No.14919-77-8 Benserazide hydrochloride

CAS No.14919-77-8 Benserazide hydrochloride

CAS No.14919-77-8 Benserazide hydrochloride

CAS No.14919-77-8 Benserazide hydrochloride

CAS No.14919-77-8 Benserazide hydrochloride

CAS No.14919-77-8 Benserazide hydrochloride

CAS No.14919-77-8 Benserazide hydrochloride

CAS No.14919-77-8 Benserazide hydrochloride

CAS No.14919-77-8 Benserazide hydrochloride

CAS No.14919-77-8 Benserazide hydrochloride

CAS No.14919-77-8 Benserazide hydrochloride

CAS No.14919-77-8 Benserazide hydrochloride

CAS No.14919-77-8 Benserazide hydrochloride

CAS No.14919-77-8 Benserazide hydrochloride

CAS No.14919-77-8 Benserazide hydrochloride

CAS No.14919-77-8 Benserazide hydrochloride

CAS No.14919-77-8 Benserazide hydrochloride

CAS No.14919-77-8 Benserazide hydrochloride

Reference