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14930-96-2

Basic Information
CAS No.: 14930-96-2
Name: CYTOCHALASIN B
Article Data: 3
Molecular Structure:
Molecular Structure of 14930-96-2 (CYTOCHALASIN B)
Formula: C29H37NO5
Molecular Weight: 479.616
Synonyms: 24-Oxa[14]cytochalasa-6(12),13,21-triene-1,23-dione,7,20-dihydroxy-16-methyl-10-phenyl-, (7S,13E,16R,20R,21E)-;2H-Oxacyclotetradecino[2,3-d]isoindole-2,18(5H)-dione,16-benzyl-6,7,8,9,10,12a,13,14,15,15a,16,17-dodecahydro-5,13-dihydroxy-9,15-dimethyl-14-methylene-,(E,E)-(5R,9R,12aS,13S,15S,15aS,16S,18aS)- (8CI);2H-Oxacyclotetradecino[2,3-d]isoindole-2,18(5H)-dione,6,7,8,9,10,12a,13,14,15,15a,16,17-dodecahydro-5,13-dihydroxy-9,15-dimethyl-14-methylene-16-(phenylmethyl)-,[5R-(3E,5R*,9R*,11E,12aS*,13S*,15S*,15aS*,16S*,18aS*)]-;NSC107658;Phomin;
EINECS: 239-000-2
Density: 1.209 g/cm3
Melting Point: 218-223 °C
Boiling Point: 740.559 °C at 760 mmHg
Flash Point: 401.676 °C
Solubility: ethanol: 20 mg/mL
Appearance: white to off-white powder
Hazard Symbols: VeryT+, ToxicT
Risk Codes: 26/27/28-63-23/24/25
Safety: 28-36/37-45
Transport Information: UN 1544 6.1/PG 2
PSA: 95.86000
LogP: 3.82090
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  • CYTOCHALASIN B

  • Casno:

    14930-96-2

    CYTOCHALASIN B

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    factory?direct?saleAppearance:White powder Storage:Sealed and preserved Package:200/Kilograms Application:healing drugs Transportation:By sea Port:Shanghai/tianjin

    Zhejiang Jiuzhou Chemical Co.,Ltd is a market-oriented and innovation-driven biopharmaceutical company. The company is focusing on the R&D, manufacturing and sales of pharmaceutica

  •  ZHEJIANG JIUZHOU CHEM CO.,LTD

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  • Cytochalasin B

  • Casno:

    14930-96-2

    Cytochalasin B

    Min.Order: 0

    FOB Price:  USD $ 0.0-0.0

    Best Seller, High Quality, Competitive Price, Fast Delivery, Quick ResponseAppearance:powder, or liquid Storage:Stored in room temperature, ventilated place Package:Bottle, barrel, cargo, container, etc. Application:Pharmaceuticals, intermediates, AP

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Chemistry

 Cytochalasin B (CAS No.:14930-96-2) is a cell-permeable mycotoxin. It inhibits cytoplasmic division by blocking the formation of contractile microfilaments. It inhibits cell movement and induces nuclear extrusion. Cytochalasin B shortens actin filaments by blocking monomer addition at the fast-growing end of polymers. Cytochalasin B inhibits glucose transport and platelet aggregation. It blocks adenosine-induced apoptotic body formation without affecting activation of endogenous ADP-ribosylation in leukemia HL-60 cells. It is also used in cloning through nuclear transfer. Here enucleated recipient cells are treated with Hoechst stain containing cytochalsin B. Cytochalasin B makes the walls of the oocytes smoother and makes it easy for micro-manipulation so that the zona pellucida is not so rigid and can be easily pierced by the micro-needles.

Uses

Chemical Name: Cytochalasin B
CAS No.: 14930-96-2
EINECS: 239-000-2
RTECS: RO0205000
Molecular Formula: C29H37NO5
Molecular Weight: 479.61 g/mol
Melting Point: 218-223 °C
Density: 1.2 g/cm3 
Flash Point: 401.7 °C
Boiling Point: 740.6 °C at 760 mmHg 
Storage temp.: -20°C
Following is the structure of Cytochalasin B (CAS No.:14930-96-2):

Toxicity Data With Reference

1.    

dni-hmn:oth 1 mg/L

    CNREA8    Cancer Research. 45 (1985),311.
2.    

dni-hmn:hla 1 µmol/L

    MUREAV    Mutation Research. 92 (1982),427.
3.    

cyt-hmn:fbr 1 mg/L

    JCLBA3    Journal of Cell Biology. 89 (1981),194.
4.    

cyt-hmn:oth 1 mg/L

    JNCIAM    Journal of the National Cancer Institute. 52 (1974),653.
5.    

cyt-mus:mmr 1 mg/L

    ITCSAF    In Vitro. 19 (1983),58.
6.    

ipr-ham TDLo:5 mg/kg (female 8D post):TER

    TJADAB    Teratology, A Journal of Abnormal Development. 22 (1980),59.
7.    

ipr-rat LD50:11 mg/kg

    TOXIA6    Toxicon. 17 (1979),137.
8.    

ipr-mus LD50:30 mg/kg

    FEPRA7    Federation Proceedings, Federation of American Societies for Experimental Biology. 38 (1979),438.

Consensus Reports

EPA Genetic Toxicology Program.

Safety Profile

Poison by intraperitoneal route. An experimental teratogen. Human mutation data reported. When heated to decomposition it emits toxic fumes of NOx.
Hazard Codes:
T+: Very toxic
T: Toxic
Risk Statements about Cytochalasin B (CAS No.:14930-96-2):
R63 Possible risk of harm to the unborn child.
R23/24/25: Toxic by inhalation, in contact with skin and if swallowed.
R26/27/28: Very toxic by inhalation, in contact with skin and if swallowed.
Safety Statements about Cytochalasin B (CAS No.:14930-96-2):
S28 After contact with skin, wash immediately with plenty of soap-suds.
S45 In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.)
S36/37: Wear suitable protective clothing and gloves.