Reference

Prevention of lysosome disruption in anoxic myocardium by chloroquine and methyl prednisolone

Prevention of lysosome disruption in anoxic myocardium by chloroquine and methyl prednisolone. Welman, Elizabeth; Peters, T. J. (Dep. Med., R. Postgrad. Med. Sch., London, Engl.). Pharmacol. Res. Commun., 9(1), 29-38 (English) 1977. CODEN: PLRCAT. DOCUMENT TYPE: Journal CA Section: 1 (Pharmacodynamics) Section cross-reference(s): 2 Isolated guinea pig hearts were perfused anoxically with various concns. 2375-03-3 and 50-63-5 which are cas registry numbers of chemicals are mentioned. of chloroquine diphosphate (I diphosphate) [50-63-5], methyl prednisolone Na succinate (II succinate) [2375-03-3] or Na succinate [150-90-3] alone. The left ventricle tissue was fractionated and the integrity of the myocardial lysosomes was estimated by measurements of latent acid hydrolase activity. Both drugs reduced the damage to lysosomes resulting from anoxic perfusion. The optimal concn. of I was 10-7 M, while II stabilized the lysosomes at 10-5-10-4M. Na succinate alone had a partial lysosome stabilizing action. .

Interactions between hyperbaric oxygen and drugs

Interactions between hyperbaric oxygen and drugs. Beubler, E.; Lembeck, F.; Stolze, A. (Inst. Exp. Klin. Pharmakol., Univ. Graz, Graz, Austria). Wien. Klin. Wochenschr., 89(8), 260-5 (German) 1977. CODEN: WKWOAO. DOCUMENT TYPE: Journal CA Section: 1 (Pharmacodynamics) The lethal effect of O under high pressure (OHP) was diminished by phenobarbitone [50-06-6], propranolol [525-66-6], clonidine [4205-91-8], Na succinate [150-90-3], and tris buffer. The lethal effect of OHP was enhanced by methamphetamine [537-46-2], acetazolamide [59-66-5] and guanethidine [55-65-2]. The lethal effect of OHP was enhanced by reserpine [50-55-5] 2 h after administration, but diminished 12 h after administration. The convulsion threshold of pentetrazol [54-95-5] was decreased under OHP by 26%. The duration of the hypnotic effect of hexobarbitone [56-29-1] was decreased under OHP by 27%. The analgesic effect of morphine [57-27-2] was unchanged by OHP. Practical aspects with regard to the use of drugs during clin. use of OHP are discussed.