CAS No.1500-85-2,4-Amino-7H-pyrrolo[2,3-d]pyrimidine Suppliers,MSDS download

Detail of "1500-85-2"

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CAS Number:

1500-85-2

Name:

4-Amino-7H-pyrrolo[2,3-d]pyrimidine

Molecular Structure:

Formula:

C₆H₆N₄

Molecular Weight:

134.14

Synonyms:

1H-Pyrrolo[2,3-d]pyrimidin-4-amine(9CI);1H-Pyrrolo[2,3-d]pyrimidine, 4-amino- (7CI);7H-Pyrrolo[2,3-d]pyrimidine, 4-amino- (6CI,8CI);4-Aminopyrrolo[2,3-d]pyrimidine;7-Deazaadenine;7H-Pyrrolo[2,3-d]pyrimidin-4-amine;

Density:

1.48 g/cm³

Boiling Point:

399.8 °C at 760 mmHg

Flash Point:

224.4 °C

Reference

Action of tubercidin and other adenosine analogs on Schistosoma mansoni schistosomules: Action of tubercidin and other adenosine analogs on Schistosoma mansoni schistosomules. Dovey, Harry F.; McKerrow, James H.; Wang, Ching C. (Dep. Pharm. Chem., Univ. California, San Francisco, CA 94143, USA). Mol. Biochem. Parasitol., 16(2), 185-98 (English) 1985. CODEN: MBIPDP. ISSN: 0166-6851. DOCUMENT TYPE: Journal CA Section: 1 (Pharmacology) Section cross-reference(s): 12 The incorporation of the radiolabeled adenosine analogs tubercidin [69-33-0], formycin A [6742-12-7], 9-deazaadenosine [77691-03-3], and adenine arabinoside [5536-17-4] into nucleotides of Schistosoma mansoni schistosomules was studied in vitro. Of the 4 analogs, only tubercidin and formycin A were incorporated into the nucleotide pool, at rates resp. 1/10th and 1/50th the rate of adenosine incorporation. Tubercidin inhibited schistosomule motility in vitro with an approx. IC50 (50% inhibitory concn.) value of 1 mM, whereas formycin A exerted no visible effect even when more of it than of tubercidin was incorporated into the nucleotides and nucleic acids. Formycin A thus acts like a nontoxic adenosine analog. 7-Deazaadenine [1500-85-2], the purine base of tubercidin, was not incorporated into nucleotides. 7-Deazaadenine, 9-deaza-adenosine, and adenine arabinoside all had no effect on schistosomule motility at concn. up to 100 mM. Formycin A blocked the incorporation of tubercidin and of adenosine with equal effectiveness, as did p-nitrobenzyl-6-mercaptopurine ribonucleoside, a specific inhibitor of nucleoside transport in many mammalian cells. Thus, formycin A, tubercidin, and adenosine appear to have a common mechanism of cellular uptake. The significant levels of adenosine phosphorylase [56126-48-8] and adenine phosphoribosyltransferase [9027-80-9] activity found in schistosomule exts. suggests that most of the transported adenosine is converted to adenine before conversion to AMP. The levels of purine nucleoside kinase (adenosine kinase and tubercidin kinases) [70356-41-1] while low, can more than account for the rate of tubercidin incorporated into intact schistosomules. The kinase(s) may also represent a minor pathway for direct adenosine incorporation. It may have a rather unusual substrate specificity because it is able to recognize adenosine, tubercidin, and formycin A as substrates, but not 9-deazaadenosine or adenine arabinoside.

Detail of "1500-85-2"

4-Amino-7H-pyrrolo[2,3-d]pyrimidine

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CAS No.1500-85-2 4-Amino-7H-pyrrolo[2,3-d]pyrimidine

CAS No.1500-85-2 4-Amino-7H-pyrrolo[2,3-d]pyrimidine

CAS No.1500-85-2 4-Amino-7H-pyrrolo[2,3-d]pyrimidine

CAS No.1500-85-2 4-Amino-7H-pyrrolo[2,3-d]pyrimidine

CAS No.1500-85-2 4-Amino-7H-pyrrolo[2,3-d]pyrimidine

CAS No.1500-85-2 4-Amino-7H-pyrrolo[2,3-d]pyrimidine

CAS No.1500-85-2 4-Amino-7H-pyrrolo[2,3-d]pyrimidine

CAS No.1500-85-2 4-Amino-7H-pyrrolo[2,3-d]pyrimidine

CAS No.1500-85-2 4-Amino-7H-pyrrolo[2,3-d]pyrimidine

CAS No.1500-85-2 4-Amino-7H-pyrrolo[2,3-d]pyrimidine

CAS No.1500-85-2 4-Amino-7H-pyrrolo[2,3-d]pyrimidine

CAS No.1500-85-2 4-Amino-7H-pyrrolo[2,3-d]pyrimidine

CAS No.1500-85-2 4-Amino-7H-pyrrolo[2,3-d]pyrimidine

CAS No.1500-85-2 4-Amino-7H-pyrrolo[2,3-d]pyrimidine

CAS No.1500-85-2 4-Amino-7H-pyrrolo[2,3-d]pyrimidine

CAS No.1500-85-2 4-Amino-7H-pyrrolo[2,3-d]pyrimidine

CAS No.1500-85-2 4-Amino-7H-pyrrolo[2,3-d]pyrimidine

CAS No.1500-85-2 4-Amino-7H-pyrrolo[2,3-d]pyrimidine

CAS No.1500-85-2 4-Amino-7H-pyrrolo[2,3-d]pyrimidine

CAS No.1500-85-2 4-Amino-7H-pyrrolo[2,3-d]pyrimidine

Reference