Detail of "1501-06-0"

Reference

Hexahydrodibenzo[b,d]pyran-9-ones as antiemetic drugs

Hexahydrodibenzo[b,d]pyran-9-ones as antiemetic drugs. Archer, Robert A.; Lemberger, Louis (Lilly, Eli, and Co., USA). U.S. US 4087545 2 May 1978, 6 pp. (English). (United States of America). CODEN: USXXAM. CLASS: IC: A01N009-28. NCL: 424283000.Except for chemicals metioned above, 1501-06-0 is also used. APPLICATION: US 76-658437 17 Feb 1976. DOCUMENT TYPE: Patent CA Section: 27 (Heterocyclic Compounds (One Hetero Atom)) Hexahydrodibenzo[b,d]pyran-9-ones I (R = H, Me; R1 = H, C1-C4 alkanoyl; R2 = C7-C10 n-alkyl or MeCR3R4 where R3 = C2-C7 alkyl and R4 = H or Me) were prepd. for use as antiemetics (no data). Thus, condensation of 5-R2C6H3(OH)2-m [R2 = Me(CH2)5CMe2 (Q)] with di-Et 2-acetylglutartate and cyclization of the product in the presence of NaH gave II (R2 = Q), which underwent 9-oxo group ketalization with HOCH2CH2OH, treatment with Me Grignard reagent, deketalization, and D10(10a)-double bond redn. with Li in liq. NH3 to give a mixt. of dl-cis- and dl-trans-I (R = Me, R1 = H, R2 = Q). .

Hexahydrodibenzo[b,d]pyran-9-ones as antiasthmatic drugs

Hexahydrodibenzo[b,d]pyran-9-ones as antiasthmatic drugs. Archer, Robert A.; Lemberger, Louis (Lilly, Eli, and Co., USA). U.S. US 4087546 2 May 1978, 6 pp. (English). (United States of America). CODEN: USXXAM. CLASS: IC: A01N009-28.Several reagents such as 1501-06-0 is used here. NCL: 424283000. APPLICATION: US 76-658438 17 Feb 1976. DOCUMENT TYPE: Patent CA Section: 27 (Heterocyclic Compounds (One Hetero Atom)) Hexahydrodibenzo[b,d]pyran-9-ones I (R = H, Me; R1 = H, C1-C4 alkanoyl; R2 = C7-C10 n-alkyl or MeCR3R4 where R3 = C2-C7 alkyl and R4 = H or Me) were prepd. for use as antiasthmatics (no data). Thus, condensation of 5-R2C6H3(OH)2-m [R2 = Me(CH2)5CMe2 (Q)] with di-Et 2-acetylglutarate and cyclization of the product in the presence of NaH gave II (R2 = Q), which underwent 9-oxo group ketalization with HOCH2CH2OH, treatment with Me Grignard reagent, deketalization, and D10(10a)-double bond redn. with Li in liq. NH3 to give a mixt. of dl-cis- and dl-trans-I (R = Me, R1 = H, R2 = Q). .