Reference

Process for preparation of chiral amlodipine salts

Joshi, Rohini Ramesh; Joshi, Ramesh Anna; Karade, Nilesh Bapurao; Gurjar, Mukund Keshav (Council of Scientific and Industrial Research, India). PCT Int. Appl. WO 2005049571 A1 2 Jun 2005, 16 pp. DESIGNATED STATES: W: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, KE, KG, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MA, MD, MG, MK, MN, MW, MX, MZ, NA, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RU, SC, SD, SE, SG, SK, SL, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, YU, ZA, ZM, ZW; RW: AT, BE, BF, BJ, CF, CG, CH, CI, CM, CY, DE, DK, ES, FI, FR, GA, GB, GR, IE, IT, LU, MC, ML, MR, NE, NL, PT, SE, SN, TD, TG, TR. (English). (World Intellectual Property Organization).In this article, certain chemicals are used. One of their cas registry numbers is 150566-71-5 CODEN: PIXXD2. CLASS: ICM: C07D211-90. ICS: C07B057-00. APPLICATION: WO 2004-IN324 19 Oct 2004. PRIORITY: IN 2003-DE1440 20 Nov 2003. DOCUMENT TYPE: Patent CA Section: 63 (Pharmaceuticals) A process for the prepn. of pharmaceutically acceptable salts of chiral Amlodipine namely S(-) Amlodipine and R(+) Amlodipine without isolation of the chiral free base wherein the product has optical purity ranging between 96-99% is described in the present invention. The process comprises resolving RS amlodipine base using L(+) or D(-) tartaric acid followed by reaction of the sepd. tartrate salt with an org. acid to obtain the salt corresponding to the acid used in ee ranging from 96-99%. .