Detail of "1509-92-8"

Reference

Biological evaluation of isomers of N-acetylmethionine and methionine in young rats

Biological evaluation of isomers of N-acetylmethionine and methionine in young rats. Jenkins, M. Young; Mitchell, G. V.; Valentine, H.; Boyd, Z. J.; Adkins, J. S. (Div. Nutr., Food Drug Adm., Washington, D. C., USA). Nutr. Rep. Int., 17(3), 377-86 (English) 1978. CODEN: NURIBL. ISSN: 0029-6635. DOCUMENT TYPE: Journal CA Section: 18 (Animal Nutrition) The addn. of equimolar quantities of 0.224% L- [348-67-4], or DL-methionine (met) [59-51-8] or 0.289% N-acetyl-D- (I) [1509-92-8], L- [65-82-7], or DL-methionine [1115-47-5] to a 10% protein basal diet caused a significant increase in growth and protein efficiency ratio in rats fed each form of methionine. All groups fed fortified diets except the one fed I had lower kidney and testes wts. as a percentage of body wt. than the controls. Hb levels were the same in all groups. Plasma albumin and liver N were increased in all fortified groups except the group fed I. Rats fed I had a higher blood urea N level than the controls (20 vs 12 mg%, P<0.05). The results indicate that I is not so well utilized as the other compds. tested.

Portal and vena caval plasma methionine concentrations in young pigs administered L-methionine, N-acetyl-L-methionine and N-acetyl-D-methionine

Portal and vena caval plasma methionine concentrations in young pigs administered L-methionine, N-acetyl-L-methionine and N-acetyl-D-methionine. Daabees, Tahia T.; Andersen, D. W.; Zike, W. L.; Filer, L. J., Jr.; Stegink, Lewis D. (Coll. Med., Univ. Iowa, Iowa City, IA 52242, USA). J. Nutr., 114(9), 1541-7 (English) 1984. CODEN: JONUAI. ISSN: 0022-3166. DOCUMENT TYPE: Journal CA Section: 18 (Animal Nutrition) N-Acyl-methionine derivs. have been proposed as replacements for methionine in supplementing food products low in this amino acid. The effects were studied of N-acetyl-L-methionine [65-82-7], N-acetyl-D-methionine [1509-92-8], and L-methionine [63-68-3] loads (2 mmol/kg body wt.) on portal and vena caval plasma amino acid concns. in 4 young pigs. L-Methionine loading increased mean portal and vena caval plasma methionine concns. from baseline values of 6.44 and 6.63 mmol/100 mL, resp., to mean peak values of 340 and 265 mmol/100 mL, resp. N-Acetyl-L-methionine loading increased mean peak portal and vena caval plasma methionine concns. to 291 and 220 mmol/100 mL, resp. N-Acetyl-L-methionine could not be detected in either portal or vena caval plasma. In contrast, N-acetyl-D-methionine loading produced only a small rise in mean peak portal and vena caval plasma methionine concns. (13.0 and 8.62 mmol/100 mL, resp.). Concns. of N-acetyl-D-methionine increased from baseline values of 0 mmol/100 mL to mean peak values of 251 and 234 mmol/100 mL, resp., in portal and vena caval plasma. These data explain the poor utilization of N-acetyl-D-methionine as a methionine source.