Detail of "151-67-7"

Reference

MAC for halothane, enflurane, and isoflurane in the New Zealand white rabbit: and a test for the validity of MAC determinations

MAC for halothane, enflurane, and isoflurane in the New Zealand white rabbit: and a test for the validity of MAC determinations. Drummond, John C. (Dep. Anesthesiol., Univ. California, San Diego, La Jolla, CA 92093, USA). Anesthesiology, 62(3), 336-8 (English) 1985. CODEN: ANESAV. ISSN: 0003-3022. DOCUMENT TYPE: Journal CA Section: 1 (Pharmacology) The MAC (min. alveolar concn.) values for halothane [151-67-7], enflurane [13838-16-9], and isoflurane [26675-46-7] in rabbits were as follows: halothane 1.39%, enflurane 2.86%, and isoflurane 2.05%. Comparison of these results with previously reported MAC values for other species suggests that the ratio of the potencies for any pair of these agents is const. from species to species. This observation provides a means for assessing the validity of preexisting or newly detd. MAC values.

In vitro responses of cat skeletal muscle to halothane and caffeine

In vitro responses of cat skeletal muscle to halothane and caffeine. Deuster, Patricia A.; Bockman, Emma L.; Muldoon, Sheila M. (Dep. Anesthesiol., Unif. Serv. Univ. Health Sci., Bethesda, MD 20814, USA). J. Appl. Physiol. (1985), 58(2), 521-7 (English) 1985. CODEN: JAPHEV. DOCUMENT TYPE: Journal CA Section: 1 (Pharmacology) Section cross-reference(s): 9 Strips of soleus (100% type I) and gracilis (90% type II) muscle were obtained from anesthetized cats and mounted in organ baths filled with aerated Krebs-Ringer soln. (37°). The contractile patterns in response to elec. stimulation (0.1 Hz, 25 V, 5 ms), caffeine [58-08-2], halothane [151-67-7], and caffeine in the presence of halothane were examd. in the 2 fiber types. The ability of 25 mM dantrolene [7261-97-4] to alter the contractile patterns was also evaluated. In vitro contractile properties in response to elec. stimulation were similar to properties obsd. in situ, except that twitch tension in soleus muscle was less in vitro than in situ. In the presence of halothane, type I soleus muscle developed a rapid contracture. The contracture was blocked by pretreatment with dantrolene and was reversed by addn. of dantrolene at the peak of the response. Halothane-induced contractures were not obsd. at any time in type II gracilis. Type I soleus was also more sensitive both to caffeine alone and to caffeine in the presence of halothane than was type II gracilis. In both fiber types, halothane increased the sensitivity of the muscles to caffeine. Dantrolene attenuated caffeine-induced contractures in both fiber types, but the attenuating effect was less in the presence of halothane. Further studies in these 2 muscles may be useful for delineating the mechanisms inducing contracture in muscle from individuals susceptible to malignant hyperthermia.