Detail of "151070-83-6"

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Use of histamine receptor H3 and gene knockout mouse for drug screening, diagnosis, and therapy of diseases associated with body weight or food intake regulation

Use of histamine receptor H3 and gene knockout mouse for drug screening, diagnosis, and therapy of diseases associated with body weight or food intake regulation. Kotani, Hidehito; Takahashi, Kazuhiko; Suwa, Hiroaki (Banyu Pharmaceutical Co., Ltd., Japan). There are some commonly used reagents like 9004-10-8 in this article. PCT Int. Appl. WO 2003004637 A1 16 Jan 2003, 73 pp. DESIGNATED STATES: W: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, KE, KG, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MA, MD, MG, MK, MN, MW, MX, MZ, NO, NZ, OM, PH, PL, PT, RO, RU, SD, SE, SG, SI, SK, SL, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VN, YU, ZA, ZM, ZW, AM, AZ, BY, KG, KZ, MD, RU, TJ, TM; RW: AT, BE, BF, BJ, CF, CG, CH, CI, CM, CY, DE, DK, ES, FI, FR, GA, GB, GR, IE, IT, LU, MC, ML, MR, NE, NL, PT, SE, SN, TD, TG, TR. (Japanese). (World Intellectual Property Organization). CODEN: PIXXD2. CLASS: ICM: C12N015-00. ICS: A61K031-711; A61P003-04; A61K048-00; G01N033-50; G01N033-15; C12N005-10. APPLICATION: WO 2002-JP6580 28 Jun 2002. PRIORITY: JP 2001-201413 2 Jul 2001. DOCUMENT TYPE: Patent CA Section: 9 (Biochemical Methods) Section cross-reference(s): 3, 6, 14 Histamine receptor H3, encoding gene, agonists, antagonists, or gene knockout higher animal for drug screening and diagnosis of diseases assocd. with body wt. or food intake regulation, is disclosed. A reporter gene linked to the histamine receptor H3 gene regulatory (promoter) region can be used. H3 receptor gene knockout animals, rodents, in particular, and animal cells, are claimed. Genetic diagnosis by RFLP or DNA amplification, and immunodiagnosis using antibodies, are also claimed. Probes targeting the histamine receptor H3 gene regulatory (promoter) region are claimed. To understand the biol. function of the histamine presynaptic autoreceptor H3, the authors inactivated the receptor through homologous recombination.There are some commonly used reagents with their cas registry numbers 151070-83-6 and 485807-89-4 in this article. H3-/- mice manifest mild obese phenotypes that are characterized by increases in body wt., food intake, and adiposity and by redns. in energy expenditure. Consistent with these observations, homozygous null mice have insulin and leptin resistance, increased levels of plasma leptin and insulin, and decreased levels of histamine in the hypothalamic/thalamic region of their brains coupled with increased histamine turnover. The expression of UCP1 in brown adipose tissue and of UCP3 in brown adipose tissue, white adipose tissue, and skeletal muscle is decreased in H3-/- mutants, and the anorexigenic activity of thioperamide is not obsd. These results suggest that neuronal histamine is a mediator of body-wt. homeostasis and that neuronal histamine functions through H3 receptors in mice. ..