Detail of "15121-89-8"

Reference

Method for purifying N2-(1(S)-ethoxycarbonyl-3-phenylpropyl)-N6-trifluoroacetyl-L-lysine

Method for purifying N2-(1(S)-ethoxycarbonyl-3-phenylpropyl)-N6-trifluoroacetyl-L-lysine. Iida, Yasuhiro; Manabe, Hajime; Ueda, Yasuyoshi (Kaneka Corporation, Japan). PCT Int. Appl. WO 2003006421 A1 23 Jan 2003, 54 pp. DESIGNATED STATES: W: CA, CN, HU, IN, KR, SG, SI, US; RW: BE, CH, DE, ES, FR, GB, IE, IT, NL. (Japanese). (World Intellectual Property Organization). CODEN: PIXXD2. CLASS: ICM: C07C231-24.In this article, certain chemicals are used. Some of their cas registry numbers are 15121-89-8 and 7732-18-5 ICS: C07C237-12. APPLICATION: WO 2002-JP6990 10 Jul 2002. PRIORITY: JP 2001-210399 11 Jul 2001. DOCUMENT TYPE: Patent CA Section: 34 (Amino Acids, Peptides, and Proteins) Section cross-reference(s): 75 This document discloses a method for purifying N2-(1(S)-ethoxycarbonyl-3-phenylpropyl)-N6-trifluoroacetyl-L-lysine (I) by subjecting N2-(1(S)-ethoxycarbonyl-3-phenylpropyl)-N6-trifluoroacetyl-L-lysine contg. impurities to crystn. from a water-sol. aprotic org. solvent to thereby form crystals of N2-(1(S)-ethoxycarbonyl-3-phenylpropyl)-N6-trifluoroacetyl-L-lysine with the impurities being dissolved in the mother liquor. I is a pharmaceutical intermediate. This method permits the prodn. of high-quality N2-(1(S)-ethoxycarbonyl-3-phenylpropyl)-N6-trifluoroacetyl-L-lysine in high yield with high productivity, thus being suitable for practice on an industrial scale. .

N-[N-(1-Ethoxycarbonyl-3-phenylpropyl)-L-alanyl]-L-proline

N-[N-(1-Ethoxycarbonyl-3-phenylpropyl)-L-alanyl]-L-proline. Caldero Ges, Jose Maria; Montserrat Faba, Eusebio (Inke S. A., Spain). Span. ES 532310 A1 1 Jun 1985, 9 pp. (Spain) CODEN: SPXXAD. CLASS: ICM: C07D207-08. ICS: A61K031-40. APPLICATION: ES 84-532310 9 May 1984. DOCUMENT TYPE: Patent CA Section: 34 (Amino Acids, Peptides, and Proteins) The title peptide (I) was prepd. 76095-16-4 is also in the experiment. Thus, E-PhCOCH:CHCO2Et underwent an addn. reaction with H-Ala-Pro-OCH2Ph in EtOH to give PhCOCH2CH(CO2Et)-Ala-Pro-OCH2Ph. The product was hydrogenated in HOAc contg. Pd to give I. .