Detail of "15176-29-1"

CAS Number:
15176-29-1
Name:
Uridine,2'-deoxy-5-ethyl-
Molecular Structure:
Formula:
C11H16 N2 O5
Molecular Weight:
256.29
Deleted CAS:
46895-01-6
Synonyms:
2'-Deoxy-5-ethyluridine;5-Ethyl-1-(2'-deoxy-b-D-ribofuranosyl)uracil; 5-Ethyl-2'-deoxyuridine; 5-Ethyldeoxyuridine;Aedurid; EDU; EUDR; Edoxudine; Epoxudine; ORF 15817; RWJ 15817; b-5-Ethyl-2'-deoxyuridine; b-5-Ethyldeoxyuridine
Density:
1.389 g/cm³
Boiling Point:
°Cat760mmHg
Flash Point:
°C
Safety:
Mutation data reported. When heated to decomposition it emits toxic vapors of NO_x. Details

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A rational approach to the development of antiviral chemotherapy: alternative substrates of herpes simplex virus type 1 (HSV-1) and type 2 (HSV-2) thymidine kinase (TK): A rational approach to the development of antiviral chemotherapy: alternative substrates of herpes simplex virus type 1 (HSV-1) and type 2 (HSV-2) thymidine kinase (TK). Cheng, Yung-Chi (Dep. Exp. Ther., Roswell Park Mem. Inst., Buffalo, N. Y., USA). Ann. N. Y. Acad. Sci., 284, 594-8 (English) 1977. CODEN: ANYAA9. DOCUMENT TYPE: Journal CA Section: 1 (Pharmacodynamics) Malignancies assocd. with herpesviruses may be controlled by inhibiting DNA synthesis by reaction products of virus thymidine kinase (TK) [9002-06-6] using an analog of deoxythymidine as a substrate which is specific for virus-induced TK but not for human TKs. 5-Ethyl- [15176-29-1], 5-propyl- [27826-74-0], and 5-allyldeoxyuridine [73-39-2] had high affinity for virus TKs but not for TKs of uninfected cells. These substrates, analogs of deoxythymidine, inhibited the replication of herpesvirus but did not affect a herpes virus mutant which lacks the ability to induce virus TK. Thus, the results indicate that there are substrates of virus-specific TK, of which phosphorylated derivs. exert inhibitory effects on replication of herpes simplex viruses.

Comparative study of the sensitizing capacity of drugs used against herpes simplex virus: Comparative study of the sensitizing capacity of drugs used against herpes simplex virus. Hausen, B. M.; Schulze, R. (Allerg.-Abt., Univ.-Hautklin., Hamburg-Eppendorf 2000/20, Fed.Several reagents with their cas registry numbers 70-00-8 and 54-42-2 are used here. Rep. Ger.). Dermatosen Beruf Umwelt, 34(6), 163-70 (German) 1986. CODEN: DBUMDB. ISSN: 0343-2432. DOCUMENT TYPE: Journal CA Section: 1 (Pharmacology) Nine antiherpes simplex drugs were tested for their ability to induce allergic sensitization in guinea pigs. 5-Ethyl-2'-deoxyuridine [15176-29-1], 5-(2E-bromovinyl)-2'-deoxyuridine [69304-47-8], and foscarnet [4428-95-9] had no allergenic activity, and that of acyclovir [59277-89-3], vidarabine [5536-17-4], idoxuridine [54-42-2], trifluridine [70-00-8], proclu [52357-17-2], and an ext. of Melissa officinalis was very weak. Thus, these drugs have only a low risk of clin. sensitization, unlike tromantadine, for which frequent side effects have been obsd. .