Reference

Synthesis of bromonaphthopyranoisoxazoles and pyrazoles as potential antimicrobial agents

Synthesis of bromonaphthopyranoisoxazoles and pyrazoles as potential antimicrobial agents. Muthusubramanian, Lakshmi; Misra, Gauri Shankar (Dep. Chem., Jammu Univ., Jammu-Tawi, India). Eur. J. Med. Chem.--Chim. Ther., 21(2), 163-6 (English) 1986. CODEN: EJMCA5. ISSN: 0223-5234. DOCUMENT TYPE: Journal CA Section: 1 (Pharmacology) Section cross-reference(s): 28 I and II (R = H or CO2Et, R1 = H, Ph, CONH2, or CSNH2) were prepd. by treatment of 6-bromo-b-naphthol [15231-91-1] with CH2:CHCN [107-13-1] giving the cyanoethoxy deriv. [106102-24-3] which was hydrolyzed to the carbethoxy deriv. [106077-28-5] followed by cyclization to 8-bromo-1-oxo-1H-2,3-dihydronaphtho[2.1-b]pyran [99514-98-4]. This on treatment with HCO2Et [109-94-4] or di-Et oxalate [95-92-1] gave III (R = H) [106077-29-6] or III (R = CO2Et) [106077-30-9] which on reaction with NH2OH, H2NNH2, PhNHNH2 [100-63-0], H2NCONHNH2.HCl [563-41-7] on H2NCSNHNH2.HCl [15183-93-4] gave the corresponding I or II derivs. Antimicrobial screening showed that I (R = H or CO2Et and R1 = CONH2 or CSNH2) showed higher antibacterial and antifungal activity than the other compds. 106077-30-9 is just another one chemical used in this study. The most potent compd. was I (R = CO2Et, R1 = CSNH2) [106102-23-2] followed by I (R = H, R1 = CSNH2) [106077-27-4]. .

Process for the preparation of hydroxy arom

Process for the preparation of hydroxy arom. carboxylates by alkoxycarbonylation or carbonylation of hydroxy arom. bromides the absence of a promotor. Eisenstadt, Amichai (Bromine Compounds Ltd., Israel). Eur. Pat. Appl. EP 461322 A1 18 Dec 1991, 7 pp. DESIGNATED STATES: R: DE, FR, GB, NL. (European Patent Organization). CODEN: EPXXDW. CLASS: ICM: C07C051-10. ICS: C07C067-36; C07C069-84; C07C065-105; C07C065-11. APPLICATION: EP 90-401643 13 Jun 1990. DOCUMENT TYPE: Patent CA Section: 25 (Benzene, Its Derivatives, and Condensed Benzenoid Compounds) A process for the prepn. of hydroxy arom. carboxylic acids comprises the carbonylation of hydroxy arom. bromides in the presence of a Group VIII element as catalyst at pH >8 in the absence of a promotor. A mixt. of p-bromophenol (1.7 g), Na2CO3 (1. 15231-91-1 and 58574-03-1 are just another two chemicals used in this study.1 g), 10% Pd/C (30 mg), and 1-butanol (10 mL) was pressurized with CO (3 atm) and heated to 150° for 17 h to give 58% Bu 4-hydroxybenzoate. .