Welcome to LookChem.com Sign In|Join Free
  • or
Home > Pharmaceutical > 152459 > 

152459-95-5

Basic Information
CAS No.: 152459-95-5
Name: Imatinib
Article Data: 82
Molecular Structure:
Molecular Structure of 152459-95-5 (Imatinib)
Formula: C29H31N7O
Molecular Weight: 493.611
Synonyms: alpha-(4-Methyl-1-piperazinyl)-3'-((4-(3-pyridyl)-2-pyrimidinyl amino)-p-tolu-p-toluidide;4-[(4-Methylpiperazin-1-yl)methyl]-N-[4-methyl-3-[(4-pyridin-3-ylpyrimidin-2-yl)amino]phenyl]benzamide;
EINECS: 604-855-6
Density: 1.256 g/cm3
Melting Point: 113°C
Boiling Point: 451°C
Flash Point: 196°C
Appearance: off white powder
Hazard Symbols: T,N
Risk Codes: R23/24/25; R40; R48/23/24; R51/53
Safety: 24/25
PSA: 86.28000
LogP: 4.61210
Synthetic route

4-((4-methylpiperazin-1-yl)methyl)benzoyl chloride dihydrochloride

152460-10-1

6-methyl-1-N-(4-(pyridin-3-yl)pyrimidin-2-yl)benzene-1,3-diamine

152459-95-5

imatinib

Conditions
ConditionsYield
Stage #1: 4-((4-methylpiperazin-1-yl)methyl)benzoyl chloride dihydrochloride; 6-methyl-1-N-(4-(pyridin-3-yl)pyrimidin-2-yl)benzene-1,3-diamine In water at 0℃;
Stage #2: With sodium hydroxide In water at 50 - 55℃; pH=9 - 9.5; Product distribution / selectivity;
99.26%
With pyridine at 0 - 20℃; for 1h; Product distribution / selectivity;95%
Stage #1: 6-methyl-1-N-(4-(pyridin-3-yl)pyrimidin-2-yl)benzene-1,3-diamine With pyridine for 0.333333h; Autoclave;
Stage #2: 4-((4-methylpiperazin-1-yl)methyl)benzoyl chloride dihydrochloride at 0 - 25℃; for 8h;
92.7%

4-((4-methylpiperazin-1-yl)methyl)benzoyl chloride dihydrochloride

N-(5-amino-2-methylphenyl)-4-(3-piridinyl)-2-pyrimidine amine

152459-95-5

imatinib

Conditions
ConditionsYield
With sodium hydroxide In water at 0 - 55℃; pH=9 - 9.5;99.26%

C17H23N4O(1+)*CF3O3S(1-)

152460-10-1

6-methyl-1-N-(4-(pyridin-3-yl)pyrimidin-2-yl)benzene-1,3-diamine

152459-95-5

imatinib

Conditions
ConditionsYield
In N,N-dimethyl-formamide at 40 - 50℃; for 6h; Time;97.8%
109-01-3

1-methyl-piperazine

404844-11-7

4-(chloromethyl)-N-(4-methyl-3-{[4-(pyridin-3-yl)pyrimidin-2-yl]-amino}phenyl)benzamide

152459-95-5

imatinib

Conditions
ConditionsYield
With potassium carbonate In N,N-dimethyl-formamide at 80℃; for 4.5h; Temperature;97.52%
In 1,4-dioxane at 135℃; for 3h; Conversion of starting material;91%
at 120 - 130℃; for 1.5h; Conversion of starting material;91%

imatinib mesylate

152459-95-5

imatinib

Conditions
ConditionsYield
With ammonia In water Product distribution / selectivity;97%
368879-17-8

4-[(4-methylpiperazin-1-yl)methyl]bromobenzene

201230-82-2

carbon monoxide

152460-10-1

6-methyl-1-N-(4-(pyridin-3-yl)pyrimidin-2-yl)benzene-1,3-diamine

152459-95-5

imatinib

Conditions
ConditionsYield
With palladium diacetate; triethylamine; 4,5-bis(diphenylphos4,5-bis(diphenylphosphino)-9,9-dimethylxanthenephino)-9,9-dimethylxanthene In 1,4-dioxane at 50℃; under 760.051 Torr; for 36h; Reagent/catalyst; Solvent; Temperature; Inert atmosphere;95.8%

4-(4-methylpiperazin-1-ylmethyl)-N-[4-methyl-3-[(4-pyridin-3-yl)pyrimidin-2-ylamino]phenyl]benzamide dimesylate

152459-95-5

imatinib

Conditions
ConditionsYield
With ammonia In water; isopropyl alcohol at 20℃; for 4h; pH=7.6 - 8.5;93%

N-(3-guanidino-4-methylphenyl)-4-((4-methylpiperazin-1-yl)methyl)benzamide

55314-16-4, 75415-01-9, 123367-26-0

3-(N,N-dimethylamino)-1-(pyridin-3-yl)prop-2-en-1-one

152459-95-5

imatinib

Conditions
ConditionsYield
In butan-1-ol at 120 - 150℃; for 5h; Inert atmosphere;93%
152460-10-1

6-methyl-1-N-(4-(pyridin-3-yl)pyrimidin-2-yl)benzene-1,3-diamine

4-((4-methylpiperazin-1-yl)methyl)benzoic acid dihydrochloride

152459-95-5

imatinib

Conditions
ConditionsYield
Stage #1: 4-[(4-methylpiperazin-1-yl)methyl]benzoic acid dihydrochloride With pyridine; thionyl chloride at 50 - 60℃; for 3h;
Stage #2: 6-methyl-1-N-(4-(pyridin-3-yl)pyrimidin-2-yl)benzene-1,3-diamine at -10 - 0℃; for 1h;
92.5%
Stage #1: 4-[(4-methylpiperazin-1-yl)methyl]benzoic acid dihydrochloride With 1,1'-carbonyldiimidazole In N,N-dimethyl-formamide at 50℃; for 2h;
Stage #2: 6-methyl-1-N-(4-(pyridin-3-yl)pyrimidin-2-yl)benzene-1,3-diamine In N,N-dimethyl-formamide at 70℃; for 12h;
91%
Stage #1: 4-[(4-methylpiperazin-1-yl)methyl]benzoic acid dihydrochloride With pyridine; thionyl chloride at 20 - 50℃; for 1 - 2h;
Stage #2: 6-methyl-1-N-(4-(pyridin-3-yl)pyrimidin-2-yl)benzene-1,3-diamine With pyridine at 0 - 25℃; for 1h; Product distribution / selectivity;
90%
581076-59-7

N-(3-bromo-4-methylphenyl)-4-((4-methylpiperazin-1-yl)-methyl)benzamide

66521-66-2

4-pyridin-3-ylpyrimidin-2-ylamine

152459-95-5

imatinib

Conditions
ConditionsYield
With tris(dibenzylideneacetone)dipalladium(0) chloroform complex; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; sodium t-butanolate In 5,5-dimethyl-1,3-cyclohexadiene at 140℃; for 5h; Temperature;92%
Stage #1: N-(3-bromo-4-methylphenyl)-4-((4-methylpiperazin-1-yl)-methyl)benzamide; 4-pyridin-3-ylpyrimidin-2-ylamine In ethanol at 60℃; for 3h; Inert atmosphere;
Stage #2: With sodium hydroxide In water pH=8.7; Reagent/catalyst;
91%
With tris(dibenzylideneacetone)dipalladium(0) chloroform complex; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; sodium t-butanolate In 5,5-dimethyl-1,3-cyclohexadiene for 5.16667h; Inert atmosphere; Reflux; Sonication;72%
Downstream Products
571186-91-9
  • Display:default sort

    New supplier

  • Imatinib

  • Casno:

    152459-95-5

    Imatinib

    Min.Order: 0

    FOB Price:  USD $ 0.0-0.0

    Best Seller, High Quality, Competitive Price, Fast Delivery, Quick ResponseAppearance:powder, or liquid Storage:Stored in room temperature, ventilated place Package:Bottle, barrel, cargo, container, etc. Application:Pharmaceuticals, intermediates, AP

    LEAPChem supplies 200,000 of raw materials, specialty chemicals, fine chemicals, building blocks and advanced intermediates. Purity: 98% - 99%. Each product is checked by Quality

  •  LEAP CHEM Co., Ltd.

    China (Mainland)  |  Contact Details

    Business Type:Trading Company

    Tel:+852-30606658

    Address:EASEY COMM BLDG 253-261 HENNESSY ROAD Hong Kong, China

       Inquiry Now

  • Imatinib

  • Casno:

    152459-95-5

    Imatinib

    Min.Order: 1 Gram

    FOB Price:  USD $ 0.0-0.0

    1. made in GMP plant, commerially 2. Normal Stock: 500kgs 3. Audit accepted. Related documents are available to offer and audited by many clients, such as Lupin, MSN, Dr reddy etc 4. Chromatographic Purity (HPLC): not less than 99.0% Appearan

    Shanghai SE Pharm Co., Ltd was headquartered in Shanghai Pudong new District. Our advantages are project analysis & integration and resources intergration according to the markets.

  •  Shanghai SE Pharm Co., Ltd

     China (Mainland)  |  Contact Details

    Business Type:Manufacturers

    Tel:0086-18616876482

    Address:Room 301, Building 1, Wuxing Road 707#, Pudong New district, Shanghai

       Inquiry Now

  • Imatinib

  • Casno:

    152459-95-5

    Imatinib

    Min.Order: 1 Gram

    FOB Price:  USD $ 0.0-0.0

    Anqing World Chemical Co.,Ltd.Mainly responsible for the development of domestic and international business.In 2015,Haikang established the second branch,called Anqing Xuanyu Medical&Technology Co., Ltd, it is an R&D company that selects reli

    World Pharmaceutical (Anhui) Co., Ltd. is a joint-stock company, consisting of Haikang Pharmaceutical (Anhui) Co., Ltd., Anqing World Chemical Co., Ltd., Anqing Proud Import & Expo

  •  Anhui Haikang Pharmaceutical Co., Ltd.

    China (Mainland)  |  Contact Details

    Business Type:Manufacturers

    Tel:+8615212980120

    Address:No.21, Huancheng West Road, Daguan District, Anqing City

       Inquiry Now

  • Imatinib Manufacturer/High quality/Best price/In stock

  • Casno:

    152459-95-5

    Imatinib Manufacturer/High quality/Best price/In stock

    Min.Order: 1 Kilogram

    FOB Price:  USD $ 3.0-3.0

    Dayangchem's R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. DayangChem can provide different quantities

    Dayang Chem (Hangzhou) Co.,Ltd. dedicated to the development, production and marketing of chemicals which is specialized in Organic compounds; Active Pharmaceutical Ingredi

  •  Dayang Chem (Hangzhou) Co.,Ltd.

     China (Mainland)  |  Contact Details

    Business Type:Lab/Research institutions

    Tel:+86-571-88938639

    Address:9/F, Unit 2 Changdi Torch Building, 259# WenSan Road, Xihu District, Hangzhou City 310012, P.R.China

       Inquiry Now

  • High quality Imatinib supplier in China

  • Casno:

    152459-95-5

    High quality Imatinib supplier in China

    Min.Order: 0 Metric Ton

    FOB Price:  USD $ 0.0-0.0

    Welcome to Simagchem, your partner in China as a premier supply of bulk specialty chemicals for industry and life science. We introduce experienced quality product and exceptional JIT service with instant market intelligence in China to benefit our

    Welcome to Simagchem, your partner in China as a premier supply of bulk specialty chemicals for industry and life science. We introduce experienced quality product and exceptional

  •  Simagchem Corporation

     China (Mainland)  |  Contact Details

    Business Type:Manufacturers

    Tel:+86-592-2680277

    Address:21/F Hualong Office Building,No.6 Hubin East Road, Xiamen,China

       Inquiry Now

  • Steady supply Imatinib Cas 152459-95-5 with high quality and high purity

  • Casno:

    152459-95-5

    Steady supply Imatinib Cas 152459-95-5 with high quality and high purity

    Min.Order: 1 Kilogram

    FOB Price:  USD $ 0.0-0.0

    Unique advantages of Imatinib Cas 152459-95-5 Guaranteed purity High quality & competitive price Quality control Fast feedback Prompt shipment Appearance:White or almost white powder Storage:Cool dry place Package:1kg/foil bag

    Wuhan Fortuna Chemical Co., Ltd, located in the predominant Wu Han City where is a traffic hinge of China, is a big integrative chemical enterprise being engaged in producing and

  •  Wuhan Fortuna Chemical Co.,Ltd

     China (Mainland)  |  Contact Details

    Business Type:Trading Company

    Tel:86-27-59207852

    Address:A2705,Dong Yi Shi Qu,129# XinHua Road,WuHan,China

       Inquiry Now

  • Imatinib

  • Casno:

    152459-95-5

    Imatinib

    Min.Order: 1 Kilogram

    FOB Price:  USD $ 0.0-0.0

    high quality Appearance:White or off-white Solid Storage:Sealed, dry, microtherm , avoid light and smell. Package:According to the demand of customer Application:Organic synthesis Transportation:by air or by sea Port:shanghai

    Located in Zhengdong New District,?Zhengzhou of Henan province, Henan Allgreen Chemical Co.,Ltd is a comprehensive high-tech modern enterprises integrating professional R&D, pro

  •  Henan Allgreen Chemical Co.,Ltd

     China (Mainland)  |  Contact Details

    Business Type:Manufacturers

    Tel:+86-0371-87507775

    Address:No 260 Dongming Road,Jinshui District

       Inquiry Now

  • Imatinib

  • Casno:

    152459-95-5

    Imatinib

    Min.Order: 1 Kilogram

    FOB Price:  USD $ 2.0-3.0

    Imatinib English name: Imatinib Chemical name: 4-[(4-Methylpiperazin-1-yl)methyl]-N-[4-methyl-3-[(4-pyridin-3-ylpyrimidin-2-yl)amino]phenyl]benzamide Category involved: bulk pharmace

    Founded in 2008, East Chemsources Limited is a professional manufacturer of supplier in food and beverage, pharmaceuticals, cosmetics and other industries. pharmaceutical field in

  •  EAST CHEMSOURCES LIMITED

     China (Mainland)  |  Contact Details

    Business Type:Manufacturers

    Tel:86-532-81906761

    Address:No.1581-12,Jinshui Road, Licang, Qingdao,China

       Inquiry Now

  • Factory Price API 99% Imatinib 152459-95-5 GMP Manufacturer

  • Casno:

    152459-95-5

    Factory Price API 99% Imatinib 152459-95-5 GMP Manufacturer

    Min.Order: 1 Gram

    FOB Price:  USD $ 0.1-0.1

    1. Factory price and high quality must be guaranteed, base on 8 years of production and R&D experience2. Free samples will be provided,ensure specifications and quality are right for customer3. Customers will receive the most professional technical s

    Xi'an Xszo Chem Co. Ltd is a wholly-owned subsidiary of the SZO Chem Group. SZO Group is composed of Xi'an Xszo Chem Co. Ltd & Shaanxi SZO Tech Co., Ltd. SZO industry Group have mo

  •  Xi'an Xszo Chem Co., Ltd.

     China (Mainland)  |  Contact Details

    Business Type:Manufacturers

    Tel:+86-029-88698540

    Address:No.16,Jingqin Rd. JingWei Industrial park,Shaanxi,China,710200

       Inquiry Now

  • lower price High quality Imatinib

  • Casno:

    152459-95-5

    lower price High quality Imatinib

    Min.Order: 1 Kilogram

    FOB Price:  USD $ 1.0-1.0

    Shanghai Seasonsgreen Chemical is a high-tech research and development, production, sale and custom synthesis set in one high-tech chemical products enterprises. Our sales and marketing division is located in Shanghai, serving international pharmaceu

    Shanghai Seasonsgreen Chemical is a high-tech research and development, production, sale and custom synthesis set in one high-tech bio chemical products enterprises. The company's

  •  Shanghai Seasonsgreen Chemical Co.,Ltd

     China (Mainland)  |  Contact Details

    Business Type:Manufacturers

    Tel:+86 156 1855 4368

    Address:No.12, Lane 356, Chengnan Road, Chuansha Town, Shanghai

       Inquiry Now

  • Imatinib

  • Casno:

    152459-95-5

    Imatinib

    Min.Order: 5 Kiloliter

    FOB Price:  USD $ 1.2-5.0

    Our main production base is located in Xuzhou industry park. We are certified both to the ISO 9001 and ISO 14001 Standards, have a safety management system in place.Our R&D team masters core technology for process-design of target building block

    Our main production base is located in Xuzhou industry park. We produce a wide range of organics including Fine chemicals, Active pharmaceutical ingredients(APIs), Veterinary, In

  •  Chemwill Asia Co., Ltd.

     China (Mainland)  |  Contact Details

    Business Type:Manufacturers

    Tel:021-51086038

    Address:High-Tech Industrial park,Chemical Economical Development Zone,Xuzhou, Jiangsu-Province, P.R.China

       Inquiry Now

  • Imatinib

  • Casno:

    152459-95-5

    Imatinib

    Min.Order: 1 Kilogram

    FOB Price:  USD $ 9.0-99.0

    Our advantages: 1. All inquiries will be replied within 12 hours. 2. Dedication to quality, supply & service. 3. Strictly on selecting raw materials. 4. Reasonable & competitive price, fast lead time. 5. Sample is available for your eva

    Our company specializes in processing and selling chemical raw materials, chemical th Asia, Europe, America, Africa and other more than 20 countries and regions. ? Companies adheri

  •  Hebei Nengqian Chemical Import and Export Co., LTD

     China (Mainland)  |  Contact Details

    Business Type:Trading Company

    Tel:+86 15632961819

    Address:hebei

       Inquiry Now

  • TIANFUCHEM--152459-95-5---Imatinib

  • Casno:

    152459-95-5

    TIANFUCHEM--152459-95-5---Imatinib

    Min.Order: 1 Metric Ton

    FOB Price:  USD $ 500.0-500.0

    Our company was built in 2009 with an ISO certificate.In the past 6 years, we have grown up as a famous fine chemicals supplier in China and we had established stable business relationships with Samsung,LG,Merck,Thermo Fisher Scientific and so

    Welcome to Henan Tianfu Chemical Co., Ltd. Our company engages in noble metal catalysts, synthesis of electronic chemical materials and Pharmaceutical, Agrochemicals, Food Additive

  •  Henan Tianfu Chemical Co., Ltd.

     China (Mainland)  |  Contact Details

    Business Type:Lab/Research institutions

    Tel:86-371-55170693/55170694

    Address:Zhengzhou International Trade New Territory,Jinshui District,Zhengzhou ,China

       Inquiry Now

  • New production CAS 152459-95-5 with best quality

  • Casno:

    152459-95-5

    New production CAS 152459-95-5 with best quality

    Min.Order: 1 Kilogram

    FOB Price:  USD $ 139.0-210.0

    WITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et

    Zhuo Zhou Wen Xi Import and Export Co., Ltd. is a company mainly engaged in the export of pharmaceutical raw materials. Its parent company is (Wen Xi Pharma), including three subs

  •  Zhuozhou Wenxi import and Export Co., Ltd

     China (Mainland)  |  Contact Details

    Business Type:Trading Company

    Tel:+86-13111626072

    Address:Room 1710, Baoxin International Phase I, 19 Guanyun East Road, Zhuozhou, Hebei

       Inquiry Now

  • Imatinib/ LIDE PHARMA- Factory supply / Best price

  • Casno:

    152459-95-5

    Imatinib/ LIDE PHARMA- Factory supply / Best price

    Min.Order: 0

    FOB Price:  USD $ 0.0-0.0

    Advantage : LIDE PHARMACEUTICALS LTD. is a mid-small manufacturing-type enterprise, engaged in pharmaceutical intermediates of R&D, custom-made and production, and also involving trading chemicals for export. We have established the R&

    LIDE PHARMACEUTICALS LIMITED is one of the fastest growing pharmaceutical company in China. We have developed strategic partnership with our manufacturing associates having state o

  •  LIDE PHARMACEUTICALS LIMITED

    China (Mainland)  |  Contact Details

    Business Type:Lab/Research institutions

    Tel:+86-25-58409506

    Address:11F, Building A1, No.288 North Zhongshan Road, Gulou District, Nanjing,210003, P.R.China.

       Inquiry Now

  • Imatinib    CAS:152459-95-5

  • Casno:

    152459-95-5

    Imatinib CAS:152459-95-5

    Min.Order: 1 Kilogram

    FOB Price:  USD $ 1.0-1.0

    Name: Imatinib Synonyms: 4-[(4-methylpiperazin-1-yl)methyl]-N-(4-methyl-3-{[4-(pyridin-3-yl)pyrimidin-2-yl]amino}phenyl)benzamide CAS: 152459-95-5 MF: C30H35N7O4S Appearance: white powder Storage:Store in cool and dry place, away from sun li

    Welcome to Henan Sinotech! Sinotech Corporation has exceptional sourcing ability for chemicals used in Organic Fine Chemicals and APIs; Inorganic chemicals; Flame Retardants;OLED

  •  Henan Sinotech Import&Export Corporation

     China (Mainland)  |  Contact Details

    Business Type:Other

    Tel:86-371-86181678

    Address:No. 260, Dongming Road,Jinshui District

       Inquiry Now

  • Imatinib  CAS NO 152459-95-5

  • Casno:

    152459-95-5

    Imatinib CAS NO 152459-95-5

    Min.Order: 1 Kilogram

    FOB Price:  USD $ 0.0-0.0

    Advantages: Hubei XinRunde Chemical Co., Ltd is a renowned pharmaceutical manufacturer. We can offer high quality products at competitive price in quick delivery with 100% custom pass guaranteed. Never stop striving to offer our best service is

    Hubei Xinrunde Chemical Co., Ltd. dedicated to the development, production and marketing of chemicals which is specialized in Organic compounds; Active Pharmaceutical Ingredient(s)

  •  Hubei Langyou International Trading Co., Ltd

    China (Mainland)  |  Contact Details

    Business Type:Other

    Tel:+8618874586545

    Address:No.43, Xinandu Industrial Park, East and West Lake District, Wuhan, Hubei, China

       Inquiry Now

  • High quality Imatinib

  • Casno:

    152459-95-5

    High quality Imatinib

    Min.Order: 100 Gram

    FOB Price:  USD $ 10.0-10.0

    1,In No Less five years exporting experience. 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Onchem specialized in APIs, chemical intermediate

    Shanghai Upbio Tech Co.,Ltd (Former Onchem (China)Co.,Ltd) is a comprehensive manufacturer and an international distribution of chemicals throughout the world, The predecessor of

  •  Shanghai Upbio Tech Co.,Ltd

     China (Mainland)  |  Contact Details

    Business Type:Lab/Research institutions

    Tel:+86-21-52196435

    Address:No.2 Floor,No.979 Yunhan Rd,Nicheng,Pudong New Area,Shanghai,China

       Inquiry Now

  • Pharmaceutical Intermediate Raw MaterialImatinib Powder with Best Price

  • Casno:

    152459-95-5

    Pharmaceutical Intermediate Raw MaterialImatinib Powder with Best Price

    Min.Order: 1 Kilogram

    FOB Price:  USD $ 450.0-450.0

    We have two GMP facilities in Hubei Province and cooperative factories in Zhejiang Province We are concentrating on the R&D and technical service of APIs and pharmaceutical intermediates FDA Approved Appearance:white Storage:2-8°C Packag

    Hubei Hanways Pharmchem Co.,Limited is a specialized company concentrating on the R&D, production, marketing and technical service of APIs and pharmaceutical intermediates. Now we

  •  HANWAYS CHEMPHARM CO.,LIMITED

    China (Mainland)  |  Contact Details

    Business Type:Trading Company

    Tel:+86-18502787239(whatsapp)

    Address:18-1-802, Green Garden, Jianghan District, Wuhan 430023, China

       Inquiry Now

  • 99% Raw Material Imatinib powder / Pharmaceutical Powder Imatinib

  • Casno:

    152459-95-5

    99% Raw Material Imatinib powder / Pharmaceutical Powder Imatinib

    Min.Order: 10 Gram

    FOB Price:  USD $ 3.5-3.5

    We are the manufacturers and suppliers of API in China, and warehouse in Germany and USA of California, which can quickly and safely deliver to your address 1.High quality and competitive price. 2.Free sample for your evaluation. 3.Promptly delivery

    Xi'an faithful BioTech Co., Ltd. is located in the beautiful city of xian. We are mainly engaged in the production of pharmaceutical intermediates, natural active ingredients, nat

  •  Xi'an Faithful Biotech Co., Ltd.

     China (Mainland)  |  Contact Details

    Business Type:Trading Company

    Tel:86-13137770562

    Address:Room 503,Unit 2,Building 3 ,TianLangDaXingJun, Daxing East Road, Lianhu District

       Inquiry Now

  • antineoplastic, Imatinib  CAS:152459-95-5

  • Casno:

    152459-95-5

    antineoplastic, Imatinib CAS:152459-95-5

    Min.Order: 1 Kilogram

    FOB Price:  USD $ 79.0-84.0

    Our company has been in existence for 10 years since its establishment. We have our own unique team. The company integrates independent research and development, production and sales. We have established famous brands at home and abroad. At prese

    Baoji Guokang Healthchem co.,ltd located in Baoji High-tech Zone,is epitomizing international,cooperative and honest.We are a young company full of action and energy,and our profes

  •  Baoji Guokang Healthchem co.,ltd

     China (Mainland)  |  Contact Details

    Business Type:Trading Company

    Tel:86-917-3909592

    Address:China

       Inquiry Now

  • Imatinib CAS:152459-95-5

  • Casno:

    152459-95-5

    Imatinib CAS:152459-95-5

    Min.Order: 1 Gram

    FOB Price:  USD $ 0.0-0.0

    Imatinib CAS:152459-95-5 Qingdao Belugas Import and Export Co., Ltd. is a scientific and technological company integrating research and development, production and trade of chemical intermediates, specializing in high quality organic intermediates,

    Qingdao Belugas Import and Export Co., Ltd. is a scientific and technological company integrating research and development, production and trade of chemical intermediates, speciali

  •  Qingdao Beluga Import and Export Co., LTD

     China (Mainland)  |  Contact Details

    Business Type:Lab/Research institutions

    Tel:+8613854236000

    Address:qingdao

       Inquiry Now

  • Factory Outlet CAS 152459-95-5 Imatinib

  • Casno:

    152459-95-5

    Factory Outlet CAS 152459-95-5 Imatinib

    Min.Order: 0 Metric Ton

    FOB Price:  USD $ 0.0-0.0

    We have overseas warehouses in California, New Laredo Mexico, Vancouver Canada, Amsterdam Netherlands, and Melbourne Australia. Overseas warehouses can provide some of the best-selling products. We look forward to the cooperation of local powerful

    Shanghai Terui OP New Material Technology Co., Ltd. is a company dedicated to the research and development, production and sales of organic compounds, pharmaceutical intermediates

  •  Shanghai Terui OP New Material Technology Co., Ltd.

    China (Mainland)  |  Contact Details

    Business Type:Trading Company

    Tel:+86 18126314766

    Address:Room 901, Building 11, Lane 388, Baifu Road, Fengxian District, Shanghai,

       Inquiry Now

  • Factory price 99% Imatinib CAS:152459-95-5

  • Casno:

    152459-95-5

    Factory price 99% Imatinib CAS:152459-95-5

    Min.Order: 100 Kilogram

    FOB Price:  USD $ 0.0-0.0

    Superiority We can customize and synthesize products that other suppliers may not be able to provide. Advantage cof, mof ligand manufacturer Product Detail bes

    Changchun Artel Import and Export Trade Co., Ltd. is located in Changchun City, Jilin Province. It is a high-tech modern private enterprise specializing in the research, developme

  •  Changchun Artel lmport and Export trade company

     China (Mainland)  |  Contact Details

    Business Type:Trading Company

    Tel:+86-0431-80543058

    Address:Dianshi Plazza,Chaoyang District

       Inquiry Now

  • Imatinib

  • Casno:

    152459-95-5

    Imatinib

    Min.Order: 1 Kilogram

    FOB Price:  USD $ 0.0-0.0

    Hello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by emai

    Shandong Hanjiang Chemical Co., Ltd. is located in Qilu Petrochemical Industrial Park, Zibo City, Shandong Province, involving pesticide, medicine, chemical industry, coating, dy

  •  Shandong Hanjiang Chemical Co., Ltd.

     China (Mainland)  |  Contact Details

    Business Type:Lab/Research institutions

    Tel:18369939125

    Address:95A, Xingyuan East Road, Zhangdian District

       Inquiry Now

  • High Quality Imatinib Manufacturer

  • Casno:

    152459-95-5

    High Quality Imatinib Manufacturer

    Min.Order: 25 Kilogram

    FOB Price:  USD $ 0.0-0.0

    Appearance:Off white powder Storage:Room temperature Package:25kg/drum Application:API Transportation:Express/Sea/Air Port:Any port in china

    Founded in 2005, Sartort, located in Hangzhou, is a leading company engaging in chemistry, pharmaceutical and advanced materials. At present, Sartort has such controlled subsidi

  •  Hangzhou Sartort Biopharma Co., Ltd

     China (Mainland)  |  Contact Details

    Business Type:Lab/Research institutions

    Tel:86-571-87039693

    Address:No. 57, Tech Park Road, Hangzhou, Zhejiang, China

       Inquiry Now

  • Imatinib cas:152459-95-5

  • Casno:

    152459-95-5

    Imatinib cas:152459-95-5

    Min.Order: 25 Gram

    FOB Price:  USD $ 90.0-100.0

    Hebei Mojin Biotechnology Co., Ltd, Our company is a professional chemical raw materials and chemical reagents research and development production enterprises. We have several production line,So we can control the lowest price. We also have several

    Hebei Mojin Biotechnology Co., Ltd, Our company is a professional in carbomer, Dibenzylamine,meglumine,lead acetate and other chemical raw materials and chemical reagents research

  •  Hebei Mojin Biotechnology Co.,Ltd

     China (Mainland)  |  Contact Details

    Business Type:Trading Company

    Tel:13231137666

    Address:room 1401,A building,Enjoy city,shijiazhuang city,hebei province,China

       Inquiry Now

  • Gleevec

  • Casno:

    152459-95-5

    Gleevec

    Min.Order: 1 Kilogram

    FOB Price:  USD $ 100.0-100.0

    API name:Gleevec Certificates: GMP, DMF CAS No.: 152459-95-5 Chemical name: 4-(4-METHYL-PIPERAZIN-1-YLMETHYL)-N-[4-METHYL-3-(4-PYRIDIN-3-YL-PYRIMIDIN-2-YLAMINO)-PHENYL]-BENZAMIDE;Imatinib(4-[(4-Methylpiperazin-1-yl)methyl]-N-[4-methyl-3

    Hangzhou JINLAN Pharm-Drugs Technology Co., Ltd (JL Pharm) is established in 2012 at the beautiful West Lake – Hangzhou city, China. The company's main business includes R&D, Produ

  •  Hangzhou JINLAN Pharm-Drugs Technology Co., Ltd

     China (Mainland)  |  Contact Details

    Business Type:Trading Company

    Tel:+86-571-86982636

    Address:Rm A606, Fuyi Center, jianqiao street, Jianggan Area

       Inquiry Now

  • Imatinib

  • Casno:

    152459-95-5

    Imatinib

    Min.Order: 0 Metric Ton

    FOB Price:  USD $ 0.0-0.0

    Hangzhou KeyingChem Co., Ltd. exported this product to many countries and regions at best price. If you are looking for the material’s manufacturer or supplier in China, KeyingChem is your best choice. Pls contact with us freely for getting det

    Hangzhou Keying Chem Co., Ltd. Is a comprehensive enterprise, dedicated to the development, production and marketing of chemicals. As a technology innovative and service profession

  •  Hangzhou Keyingchem Co.,Ltd

     China (Mainland)  |  Contact Details

    Business Type:Lab/Research institutions

    Tel:+86-571-85378921

    Address:Jintong international Building, No.113,Huayuangang Street, Gong shu District, Hangzhou,Zhejiang, China.

       Inquiry Now

  • Imatinib

  • Casno:

    152459-95-5

    Imatinib

    Min.Order: 10 Kilogram

    FOB Price:  USD $ 0.0-0.0

    Our Advantage: high quality with competitive price High quality standard: BP/USP/EP Enterprise standard All purity customized Fast and safe delivery We have reliable forwarder who can help us deliver our goods more fast and safe. We

    Wuhan Han Sheng New Material Technology Co. Ltd is a professional company which specialized in manufacturing and selling chemical raw materials, chemical products, pharmaceutical i

  •  Wuhan Han Sheng New Material Technology Co.,Ltd

    China (Mainland)  |  Contact Details

    Business Type:Trading Company

    Tel:17798174412

    Address:Room 401, Floor 4, Building 3-1, Guandong Science and Technology Industrial Park, Jiayuan Road, Guandong Street, Donghu Hi tech Development Zone, Wuhan

       Inquiry Now

  • afine+Imatinib

  • Casno:

    152459-95-5

    afine+Imatinib

    Min.Order: 0

    FOB Price:  USD $ 0.0-0.0

    Our Services 1. New Molecules R&D 2. Own test center HPLC NMR GC LC-MS 3. API and Intermediates from China reputed manufacturers 4. Documents support COA MOA MSDS DMF open part Our advantages 1. Government awarded company. Top 100 enter

    AFINE CHEMICALS LIMITED is specialized in the fine chemicals and pharmaceuticals and we have enjoyed great popularity in world markets. Since 2005, we have been rapidly growing to

  •  Afine Chemicals Limited

     China (Mainland)  |  Contact Details

    Business Type:Lab/Research institutions

    Tel:+86-571-85134551

    Address:No. 206 Zhen Hua Road, Hangzhou 310030, Zhejiang, China

       Inquiry Now

  • Imatinib

  • Casno:

    152459-95-5

    Imatinib

    Min.Order: 0

    FOB Price:  USD $ 0.0-0.0

    J&H CHEM R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. J&H CHEM has some Manufacturing base in Jia

    J&H Chemical is one of China's leading providers of integrated fine chemical services including offering, research and development, Custom manufacturing business, as well as other

  •  Hangzhou J&H Chemical Co., Ltd.

     China (Mainland)  |  Contact Details

    Business Type:Lab/Research institutions

    Tel:+86-571-87396432

    Address:No.200 Zhenhua Rd.Xihu Industrial Park, Hangzhou 310030, China

       Inquiry Now

  • Imatinib

  • Casno:

    152459-95-5

    Imatinib

    Min.Order: 1 Gram

    FOB Price:  USD $ 0.0-0.0

    Why Choose Us: 1. Factory direct sales, so we can provide the competitive price and high quality product base on 8 years of production and R&D experience. 2. It is available in stock for quick shipment.Products could be packaged according to cu

    Shaanxi Cuikang Pharmaceutical Technology Co., Ltd. was established in January 2023 and is a wholly-owned subsidiary of Shaanxi Cuicheng Biopharmaceutical Technology Co., Ltd. It i

  •  Shaanxi Cuicheng Biomedical Technology Co., Ltd.

     China (Mainland)  |  Contact Details

    Business Type:Other

    Tel:+8613119157289

    Address:Chang'an District Western Life Science and Technology Park

       Inquiry Now

  • Imatinib Manufacturer/High quality/Best price/In stock CAS NO.152459-95-5

  • Casno:

    152459-95-5

    Imatinib Manufacturer/High quality/Best price/In stock CAS NO.152459-95-5

    Min.Order: 100 Gram

    FOB Price:  USD $ 10.0-100.0

    1. We can provide customers with "one-stop"packaging service,from research,development,production,export and so on 2. Powerful R&D strength let our technology in a leading level,forever,in turn,to provide customers with better service .

    Our company, is a professional engaged in the production and management of pharmaceutical intermediates and chemical import and export trade companies. The company has a long-term

  •  Wuhan Xinhao Biotechnology Co., Ltd.

     China (Mainland)  |  Contact Details

    Business Type:Trading Company

    Tel:18302762349

    Address:912-1, Shanhe Building, Fruit Lake Street, Wuchang District

       Inquiry Now

  • Imatinib/High quality/Best price

  • Casno:

    152459-95-5

    Imatinib/High quality/Best price

    Min.Order: 1 Gram

    FOB Price:  USD $ 1.0-1.0

    Massive Chemical is certified with ISO9001 and ISO14001 manufacturer for this product. We will offer all documents as requirement for the materials which includes, Certificate of Analysis, Material Safety Data Sheet, and Method of Analysis and

    Shanghai Massive Chemical Technology Co., Ltd. is engaged in development, production and marketing Specialty Chemicals to satisfy the changing needs of the chemical industry. We sp

  •  Shanghai Massive Chemical Technology Co., Ltd.

     China (Mainland)  |  Contact Details

    Business Type:Lab/Research institutions

    Tel:+86 21 34943721

    Address:Room 435, 4th floor, Building 9, No. 2568 Gudai Road,Minhang District, Shanghai,

       Inquiry Now

  • High quality Imatinib

  • Casno:

    152459-95-5

    High quality Imatinib

    Min.Order: 10 Gram

    FOB Price:  USD $ 100.0-100.0

    Zibo Hangyu Biotechnology Development Co., Ltd is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemi

    Hangyu Biotech is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and O

  •  Zibo Hangyu Biotechnology Development Co., Ltd

    China (Mainland)  |  Contact Details

    Business Type:Lab/Research institutions

    Tel:86-15965530500

    Address:Room1701, Tianxing Building,Licheng district, jinan, Shandong, China

       Inquiry Now

Post a RFQ

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

1

What can I do for you?
Get Best Price

Get Best Price for 152459-95-5

History

 Imatinib (CAS NO.152459-95-5) was developed by rational drug design. After the Philadelphia chromosome mutation and defective bcr-abl protein were discovered, the investigators screened chemical libraries to find a drug that would inhibit that protein. They identified 2-phenylaminopyrimidine with high-throughput screening, then it is tested and modified by the introduction of methyl and benzamide groups to give it enhanced binding properties, producing Imatinib.

Specification

1. Introduction of Imatinib
Imatinib is one kind of white to off-white crystalline or pale yellow powder. The IUPAC Name of this chemical is 4-[(4-Methylpiperazin-1-yl)methyl]-N-[4-methyl-3-[(4-pyridin-3-ylpyrimidin-2-yl)amino]phenyl]benzamide. Besides, Imatinib belongs to Molecular Targeted Antineoplastic;Pharmaceutical intermediate;Imatinib. In addition, the Classification Code of this chemical is Antineoplastic; Antineoplastic Agents; Enzyme Inhibitors; Protein Kinase Inhibitors. Imatinib is very soluble in water at pH < 5.5 (mesylate salt). It should be stored at refrigerator.

2. Properties of Imatinib
Physical properties about Imatinib are:
(1)Index of Refraction:  1.671; (2)Surface Tension:  63.6 dyne/cm; (3)Density:  1.255 g/cm3; (4)H bond acceptors:  8; (5)H bond donors:  2; (6)Freely Rotating Bonds:  6; (7)Polar Surface Area:  68.7 Å2; (8)Index of Refraction:  1.671; (9)Molar Refractivity:  147.09 cm3; (10)Molar Volume:  393 cm3; (11)XLogP3-AA: 3.5; (12)H-Bond Donor: 2; (13)H-Bond Acceptor: 7; (14)Rotatable Bond Count: 7; (15)Tautomer Count: 6; (16)Exact Mass: 493.259009; (17)MonoIsotopic Mass: 493.259009; (18)Topological Polar Surface Area: 86.3; (19)Heavy Atom Count: 37; (20)Formal Charge: 0; (21)Complexity: 706; (22)Isotope Atom Count: 0; (23)Defined Atom Stereocenter Count: 0; (24)Undefined Atom Stereocenter Count: 0; (25)Defined Bond Stereocenter Count: 0; (26)Undefined Bond Stereocenter Count: 0; (27)Covalently-Bonded Unit Count: 1; (28)Feature 3D Acceptor Count: 3; (29)Feature 3D Donor Count: 2; (30)Feature 3D Cation Count: 3; (31)Feature 3D Ring Count: 5; (32)Effective Rotor Count: 9.2; (33)Conformer Sampling RMSD: 1.

3. Structure Descriptors of Imatinib
(1)SMILES: O=C(Nc3ccc(c(Nc2nc(c1cccnc1)ccn2)c3)C)c4ccc(cc4)CN5CCN(CC5)C
InChI: InChI=1/C29H31N7O/c1-21-5-10-25(18-27(21)34-29-31-13-11-26(33-29)24-4-3-12-30-19-24)32-28(37)23-8-6-22(7-9-23)20-36-16-14-35(2)15-17-36/h3-13,18-19H,14-17,20H2,1-2H3,(H,32,37)(H,31,33,34)
(2)InChIKey: KTUFNOKKBVMGRW-UHFFFAOYAJ
(3)Std. InChI: InChI=1S/C29H31N7O/c1-21-5-10-25(18-27(21)34-29-31-13-11-26(33-29)24-4-3-12-30-19-24)32-28(37)23-8-6-22(7-9-23)20-36-16-14-35(2)15-17-36/h3-13,18-19H,14-17,20H2,1-2H3,(H,32,37)(H,31,33,34)
(4)Std. InChIKey: KTUFNOKKBVMGRW-UHFFFAOYSA-N

4. Uses of Imatinib
Imatinib is used in chronic myelogenous leukemia (CML), gastrointestinal stromal tumors (GISTs) and a number of other malignancies. Imatinib (originally STI571) is a drug used to treat certain cancers. It is the first member of a new class of agents that act by inhibiting particular tyrosine kinase enzymes, instead of non-specifically inhibiting rapidly dividing cells.

5. Production of Imatinib
N-(5-Amino-2-methylphenyl)-4-(3-pyridyl)-2-pyrimidineamine and 4-(4-Methylpiperazin-1-ylmethyl)benzoyl chloride can used to manufacture Imatinib when them are soluble in Azabenzene. And the condition of this reaction can be taken place under the room temperature and nitrogen. Then stir them, reduced pressure concentration, add water, cooling, filter, filter cake vacuum drying, join methylene chloride - methanol, and filtering. At last, you can get the Imatinib.