Detail of "15248-39-2"

Reference

Diastereoselective radical cyclization reactions; the synthesis of O-methylcorytenchirine

Diastereoselective radical cyclization reactions; the synthesis of O-methylcorytenchirine. Beckwith, Athelstan L. J.; Mayadunne, T. A. (Res. Sch. Chem. Dep. Chem., Australian Natl. Univ., Canberra ACT 0200, Australia). ARKIVOC (Gainesville, FL, United States), (10), 80-93 (English) 2004 Arkat USA Inc.Several substances with their cas registry numbers 15248-39-2 and 825612-18-8 may be metioned in this study. URL: http://www.arkat-usa.org/ark/journal/2004/Rickards/RI-1149C/RI-1149C .pdf. CODEN: AGFUAR. DOCUMENT TYPE: Journal; (online computer file) CA Section: 31 (Alkaloids) Section cross-reference(s): 27 Highly diastereoselective cyclization of radicals provides a model for the synthesis of 8-substituted berbines. Thus the reaction of 6,7-dimethoxyisoquinoline with 2-bromo-4,5-dimethoxyphenylacetyl chloride affords the key intermediate, which undergoes free radical cyclization on treatment with tributylstannane to give (±)-I as the sole product. Redn. of I affords (±)-O-methylcorytenchirine. The carbamate II does not undergo radical cyclization when treated with tributylstannane, but the acetyl pyridine III affords the cyclized products in reasonable yield and with good diastereoselectivity. .

Isoquinoline-N-boranes as precursors to substituted tetrahydroisoquinolines

Isoquinoline-N-boranes as precursors to substituted tetrahydroisoquinolines. Brooks, Donald J.Several substances are used for example 15248-39-2 and 87803-15-4 which are their cas registry numbers.; Dowell, David S.; Minter, David E.; Villarreal, Mark C. (Dep. Chem., Texas Christ. Univ., Fort Worth, TX 76129, USA). J. Org. Chem., 49(1), 130-3 (English) 1984. CODEN: JOCEAH. ISSN: 0022-3263. DOCUMENT TYPE: Journal CA Section: 31 (Alkaloids) Section cross-reference(s): 27 A new approach to the synthesis of 1,2-disubstituted 1,2,3,4-tetrahydroisoquinolines from isoquinoline-N-boranes is described. The method is a one-pot operation in which substituents are introduced consecutively as electrophiles and nucleophiles with accompanying redn. of the heterocyclic ring. This procedure differs from the classical ones in that both requisite rings are present in the starting material and thus avoids the inefficient cyclizations of phenethylamine derivs. when unactivated substrates would be required. The synthetic utility of this process is demonstrated with several examples including the alkaloids carnegine (I) and hydrohydrastinine (II). .