Detail of "15260-10-3"

CAS Number:
15260-10-3
Name:
L-Threonine,N-[(1,1-dimethylethoxy)carbonyl]-O-(phenylmethyl)-
Superlist Name:
Boc-O-Benzyl-L-threonine
Molecular Structure:
Formula:
C₁₆H₂₃NO₅
Molecular Weight:
309.36
Deleted CAS:
111516-03-1|172846-16-1|54784-63-3
Synonyms:
Butyricacid, 3-(benzyloxy)-2-(carboxyamino)-, N-tert-butyl ester, Ls-threo- (8CI);(2S,3R)-2-(tert-Butoxycarbonylamino)-3-benzyloxybutanoic acid;BOC-Thr(Bzl)-OH;N-(tert-Butoxycarbonyl)threonine benzyl ether;N-tert-Butoxycarbonyl-O-benzyl-L-threonine;NSC 334365;tert-Butoxycarbonyl-O-benzylthreonine;
EINECS:
239-304-5
Density:
1.152 g/cm³
Melting Point:
80-82 °C(lit.)
Boiling Point:
461.5 °C at 760 mmHg
Flash Point:
232.9 °C
Solubility:
Insoluble in water and petroleum ether, soluble in ethyl acetate and methanol
Safety:
22-24/25 Details
particular:
particular

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Reference

Threonyl-lysyl-proline as an anti-inflammatory, anti-allergic or analgesic agent: Threonyl-lysyl-proline as an anti-inflammatory, anti-allergic or analgesic agent. Capron, Andre; Joseph, Michel; Dautrevaut, Michel; Auriault, Claude; Dessaint, Jean Paul; Fougereau, Michel (Institut Pasteur de Lille; Institut Pasteur Fondation, Fr.Some chemicals with cas registry numbers like 41961-56-2 and 2389-45-9 are also used.). PCT Int. Appl. WO 8400108 A1 19 Jan 1984, 17 pp. DESIGNATED STATES: W: JP, US. (French). (World Intellectual Property Organization). CODEN: PIXXD2. CLASS: IC: A61K037-02; C07C103-52. APPLICATION: WO 83-FR134 4 Jul 1983. PRIORITY: FR 82-12222 2 Jul 1982. DOCUMENT TYPE: Patent CA Section: 63 (Pharmaceuticals) Section cross-reference(s): 34 L-Threonyl-L-lysyl-L-proline (I) [41961-56-2] or its salts is useful as an anti-inflammatory, anti-allergic or antalgic agent. Thus, tert-butoxycarbonylproline [15761-39-4] was treated with a chloromethylated deriv. of styrene-divinylbenzene copolymer in a mixt. of Et3N and EtOH. The reaction mixt. was washed with a soln. of CF3CO2H in CH2Cl2. The washed resin was coupled with Na-tert-butoxycarbonyl-Ne-carbobenzyloxylysine [2389-45-9] in CH2Cl2 in the presence of DCC and the resulting product was coupled (after removal of the protecting group) with Na-tert-butoxycarbonyl-O-benzylthreonine [15260-10-3]. The tripeptide, I, obtained was sepd. and washed and lyophilized. Capsules were prepd. contg. I Na salt [89705-52-2] 20 mg. .

Synthesis of asparagine-linked glycopeptides on a polymeric solid support: Synthesis of asparagine-linked glycopeptides on a polymeric solid support. Danishefsky, Samuel J.; Roberge, Jacues; Beebe, Xenia ( Sloan-Kettering Institute for Cancer Research, USA). PCT Int. 15260-10-3 and 167414-29-1 are also occured in this study. Appl. WO 9640198 A1 19 Dec 1996, 163 pp. DESIGNATED STATES: W: AU, CA, JP, MX; RW: AT, BE, CH, DE, DK, ES, FI, FR, GB, GR, IE, IT, LU, MC, NL, PT, SE. (English). (World Intellectual Property Organization). CODEN: PIXXD2. CLASS: ICM: A61K038-00. ICS: C07K009-00. APPLICATION: WO 1996-US10229 7 Jun 1996. PRIORITY: US 1995-477776 7 Jun 1995. DOCUMENT TYPE: Patent CA Section: 34 (Amino Acids, Peptides, and Proteins) Section cross-reference(s): 1, 33 Asparagine-linked glycopeptides were prepd. by halosulfonamidating a glycal, followed by azidation, acylation, redn., peptide coupling, and deprotection steps. The glycopeptides are useful as vaccines for inducing antibodies to human breast cancer cells in adjuvant therapy. Thus, glycal I (R = polymer support, R1R2 = bond) and 9-anthracenesulfonamide suspended in THF were treated with iodonium bis(sym-collidine) perchlorate to give I (R = polymer support, R1 = 9-anthracenesulfonamide, R2 = iodo), which was treated sequentially with tetrabutylammonium azide in THF, Ac2O/4-(dimethylamino)pyridine in THF, and 1,3-propanedithiol/diisopropylethylamine in DMF to afford I (polymer support, R = NH2, R1 = NHAc). The latter underwent peptide coupling at the NH2 group to afford asparagine-linked glycopeptides. .

Detail of "15260-10-3"

L-Threonine,N-[(1,1-dimethylethoxy)carbonyl]-O-(phenylmethyl)-

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Reference