Reference

In vitro activity against Escherichia coli of CGP 9000, a new oral cephalosporin

In vitro activity against Escherichia coli of CGP 9000, a new oral cephalosporin. Greenwood, David (Queen's Med. Cent., Univ. Hosp., Nottingham, Engl.). J. Antibiot., 31(7), 697-702 (English) 1978. CODEN: JANTAJ. ISSN: 0021-8820. DOCUMENT TYPE: Journal CA Section: 3 (Biochemical Interactions) Section cross-reference(s): 1 E. coli strains ECSA1, ECSA2, and Ara (ampicillin and cephalosporin sensitive) were sensitive to CGP 9000 (I) [51762-05-1], cephalexin (II) [15686-71-2], and cephalothin (III) [153-61-7] at 16, 16 or 32, and 8 or 16 mg/mL, resp. Strains Far, Bur, Gen, and Hos (b-lactamase producing strains that are ampicillin-resistant and sensitive to cephalosporins depending on inoculum size), were inhibited at 16 or 32, 4-16, and 4-32 mg/mL for I, II, and III, resp. Continuous turbidity-monitoring of dense cultures indicated that the intrinsic lytic activity of I was intermediate between that of II and that of III. ECSA1 in an in vitro infected urinary bladder model recovered growth in 7, 6, and 6.5 h after single 500 mg/mL pulse of I, II, and III, resp., whereas recovery for the Hos strain was 4 h for I and III, but 3.5 h for II. I has intrinsic activity comparable to other cephalosporins, but like other antibiotics of this group, its activity against dense bacterial populations of b-lactamase producing E. coli appears to be less than conventional tests would predict.

In vitro antibiotic sensitivity of Moraxella species

In vitro antibiotic sensitivity of Moraxella species. Rosenthal, Samuel L.; Freundlich, Lawrence F.; Gilardi, Gerald L.; Clodomar, Francine Y. (Dep. Lab. Med., Albert Einstein Coll. Med., Bronx, N. Y., USA). Chemotherapy (Basel), 24(6), 360-3 (English) 1978. CODEN: CHTHBK. ISSN: 0009-3157. DOCUMENT TYPE: Journal CA Section: 3 (Biochemical Interactions) Minimal inhibitory concns. of 17 antibacterial agents for 34 Moraxella strains were detd. using a plate diln. method. A strain of M. nonliquefaciens was found which produced b-lactamase [9073-60-3] and was resistant to ampicillin [69-53-4] and carbenicillin [4697-36-3] but not to cephalothin [153-61-7]. Several strains were relatively resistant to erythromycin [114-07-8] and sulfisoxazole [127-69-5]. Disk sensitivity tests could be used to reliably predict penicillin [1406-05-9] and erythromycin resistance but not sulfisoxazole resistance.