Detail of "1538-75-6"

Reference

2-Aminopyridines starting from N-oxides of 2-pyridinecarboxylic acids

2-Aminopyridines starting from N-oxides of 2-pyridinecarboxylic acids. Quarroz, Daniel (Lonza A.-G., Switz.). Eur. Pat. Appl. EP 90173 A1 5 Oct 1983, 10 pp. DESIGNATED STATES: R: AT, BE, CH, DE, FR, GB, IT, LI, NL, SE.There are some reagents with their cas registry numbers 1538-75-6 and 609-71-2 are used in this study. (German). (European Patent Organization). CODEN: EPXXDW. CLASS: IC: C07D213-73; C07D213-80; C07D215-38. APPLICATION: EP 83-101710 22 Feb 1983. PRIORITY: CH 82-1979 31 Mar 1982. DOCUMENT TYPE: Patent CA Section: 27 (Heterocyclic Compounds (One Hetero Atom)) Aminopyridines I (R = H, CO2H, C1-8alkyl, aryl; n = 1-4) were prepd. by treating pyridinecarboxylic acid oxides II with carboxylic anhydrides and a tertiary amine in the presence of a carbonitrile and hydrolyzing the reaction product. A mixt. of Ac2O, NEt3, and MeCN was treated with isocinchomeronic acid N-oxide at 40° to cessation of CO2 evolution (~1 h), the mixt. concd., and the product sapond. with 10% KOH at 80° to give 49% I (Rn = 5-CO2H). Acidifying the mother liquor gave 8% 6-hydroxynicotinic acid. .

Preparation of pleuromutilin derivatives containing a hydroxyamino- or acyloxyamino-cycloalkyl group as antimicrobials

All Rights Reserved. Preparation of pleuromutilin derivatives containing a hydroxyamino- or acyloxyamino-cycloalkyl group as antimicrobials. Mang, Rosemarie; Ascher, Gerd; Ferencic, Mathias; Heilmayer, Werner; Novak, Rodger (Nabriva Therapeutics Forschungs G.m.b.H., Austria). PCT Int. Appl. WO 2007000004 A1 4 Jan 2007, 26pp. DESIGNATED STATES: W: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LV, LY, MA, MD, MG, MK, MN, MW, MX, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC; RW: AT, BE, BF, BJ, CF, CG, CH, CI, CM, CY, DE, DK, ES, FI, FR, GA, GB, GR, IE, IS, IT, LU, MC, ML, MR, NE, NL, PT, SE, SN, TD, TG, TR.Several substances with their cas registry numbers 917979-08-9 and 1538-75-6 may be metioned in this study. (English). (World Intellectual Property Organization). CODEN: PIXXD2. APPLICATION: WO 2006-AT260 26 Jun 2006. PRIORITY: GB 2005-13060 27 Jun 2005; GB 2005-15997 3 Aug 2005. DOCUMENT TYPE: Patent CA Section: 30 (Terpenes and Terpenoids) Section cross-reference(s): 1, 63 Pleuromutilin derivs. of formula I [R1 = H, acyl; R2 = OH, acyloxy; R3, R6-R9 = H, D, halo; R4, R5 = H, alkyl; X = S, O, (substituted) NH; Y = S, O; Z = (substituted) cycloalkyl; m = 0-4] are prepd. These compds. are useful as pharmaceuticals, particularly as antimicrobials (no data). .