Reference

In vitro dissolution test correlating quantitatively with sustained released phenylpropanolamine absorption in man

In vitro dissolution test correlating quantitatively with sustained released phenylpropanolamine absorption in man. Tomida, Yoshinao; Yokohama, Shigeharu; Maki, Masatomo; Toguchi, Hajime; Shimamoto, Tsugio (Cent. Res. Div., Takeda Chem. Ind. Ltd., Osaka, Japan). Takeda Kenkyusho Ho, 36(1-2), 83-9 (English) 1977. CODEN: TAKHAA. DOCUMENT TYPE: Journal CA Section: 63 (Pharmaceuticals) Dissoln. profiles of phenylpropanolamine-HCl [154-41-6] from Spansule type sustained release beads in various simulated gastrointestinal fluids were obtained with the [Japanese Pharmacopeia] JP-VIII disintegration test app. Using a pharmacokinetic model, in vivo dissoln. behaviors were estd. from urinary excretion data and compared with in vitro dissoln. profiles. The best fit of in vitro-in vivo data was obsd. when beads were shaken in the JP-III 1st fluid for 1 hr, then transferred into the JP-VIII 2nd fluid contg. 0.01% gall powder and shaken subsequently for more than 6 hr. The addition of gall powder into the 2nd fluid accelerated the dissoln. rate owing probably to the improvement of the wetting property of the beads. It is assumed that a similar mechanism is the most important factor for dissoln. of beads in the intestine. Furthermore, the addn. of synthesized surfactants which lowered the contact angle on glycerides-disk gave similar results to those obtained with 2nd fluid contg. gall powder.

Some applications of bonded-phase high-performance liquid chromatography to the analysis of pharmaceutical formulations

Some applications of bonded-phase high-performance liquid chromatography to the analysis of pharmaceutical formulations. Cox, G. B.; Loscombe, C. R.; Sugden, K. (Lab. Gov. Chem., London, Engl.). Anal. Chim. Acta, 92(2), 345-52 (English) 1977. CODEN: ACACAM. DOCUMENT TYPE: Journal CA Section: 64 (Pharmaceutical Analysis) Chromatog. procedures are presented for the detn. of guaiphenesin [93-14-1], phenylephrine-HCl [61-76-7], phenylpropanolamine-HCl [154-41-6], pholcodine [509-67-1], Me [99-76-3] and Pr 4-hydroxybenzoate [94-13-3], and tyrothricin [1404-88-2] in some pharmaceutical products. An investigation of the contamination of ambazone lozenges with aspirin [50-78-2], paracetamol [103-90-2], phenacetin [62-44-2], prednisone [53-03-2], and prednisolone [50-24-8] is reported, together with the prepn. of a novel bonded weak cation-exchange packing used.