CAS No.154-69-8,TRIPELENNAMINE HYDROCHLORIDE Suppliers

Products Categories

Pharmaceutical (88)
Organic Chemicals (16)
Others (9)
Reagent (3)
Plant Extract (2)
Materials (1)

Basic Information

Molecular Structure:
CAS No.:	154-69-8
Name:	TRIPELENNAMINE HYDROCHLORIDE

Formula:	C₁₆H₂₂ClN₃
Molecular Weight:	291.824
Synonyms:	1,2-Ethanediamine,N,N-dimethyl-N'-(phenylmethyl)-N'-2-pyridinyl-, monohydrochloride (9CI);Pyridine, 2-[benzyl[2-(dimethylamino)ethyl]amino]-, monohydrochloride (8CI);2-[Benzyl[2-(dimethylamino)ethyl]amino]pyridine hydrochloride;Dehistin monohydrochloride;N,N-Dimethyl-N'-(2-pyridyl)-N'-benzylethylenediamine hydrochloride;NIH 10186;PBZ;Piristin;Pyribenzamine monohydrochloride;Pyrinamine;ReCovr;Stanzamine;Tripelennamine hydrochloride;Tripelennamine monohydrochloride;Vetibenzamine;Vetobenzamina;
EINECS:	205-833-5
Density:	1.20
Melting Point:	192-193 °C
Boiling Point:	387.8 °C at 760 mmHg
Flash Point:	188.3 °C
Appearance:	White solid
Hazard Symbols:	Xn
Risk Codes:	22-36/37/38
Safety:	26-36
PSA:	19.37000
LogP:	3.45180

Synthetic route

: 7647-01-0
hydrogenchloride

: cobalt(II) chloride hexahydrate

: 154-69-8
tripelennamine hydrochloride

: 220156-62-7
N-benzyl-N',N'-dimethyl-N-(2-pyridinio)-1,2-ethanediammonium tetrachlorocobaltate(II)

Conditions

Conditions	Yield
In hydrogenchloride equimolar amts. of CoCl2 and ligand, 6 M HCl; crystn. overnight, washing (EtOH), recrystn. (MeCN, room temp., slow evapn);

...Expand

: 154-69-8
tripelennamine hydrochloride

: cucurbit[7]uril

: tripelennamine monohydrochloride-cucurbit[7]uril 1:1 complex

Conditions

Conditions	Yield
In water pH=8;

Total:104 Page 1 of 3 1 2 3 Next>>

Post a RFQ

Cas No.:

Product Name:

Quantity:

Email:

Company name:

Valid Period:

Detailed Requirements:

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

What can I do for you?
Get Best Price

Get Best Price for 154-69-8

Specification

The Tripelennamine hydrochloride, also known as 1,2-Ethanediamine, N,N-dimethyl-N'-(phenylmethyl)-N'-2-pyridinyl-, monohydrochloride, is an organic compound with the formula C₁₆H₂₂ClN₃. Its EINECS registry number is 205-833-5. With the CAS registry number 154-69-8, its IUPAC name is N'-benzyl-N,N-dimethyl-N'-pyridin-2-ylethane-1,2-diamine hydrochloride. Tripelennamine hydrochloride is a white, crystalline material which is stable, nonhygroscopic, and readily soluble in water. Tripelennamine hydrochloride is characterized by its capacity to antagonize many of the pharmacologic effects of histamine.

Physical properties of Tripelennamine hydrochloride are: (1)ACD/LogP: 2.78; (2)ACD/LogD (pH 5.5): -0.32; (3)ACD/LogD (pH 7.4): 0.86; (4)ACD/BCF (pH 5.5): 1.00 ; (5)ACD/BCF (pH 7.4): 1.00; (6)ACD/KOC (pH 5.5):1.00; (7)ACD/KOC (pH 7.4): 9.21; (8)#H bond acceptors: 3; (9)#Freely Rotating Bonds: 6; (10)Index of Refraction: 1.594; (11)Molar Refractivity: 80.765 cm³; (12)Molar Volume: 238.124 cm³; (13)Polarizability: 32.018 10-24cm³; (14)Surface Tension: 46.1459999084473 dyne/cm; (15)Density: 1.072 g/cm³; (16)Flash Point: 188.343 °C; (17)Enthalpy of Vaporization: 63.693 kJ/mol; (18)Boiling Point: 387.814 °C at 760 mmHg

When you are using this chemical, please be cautious about it as the following:
This chemical may cause damage to health. It is irritating to eyes, respiratory system and skin. In case of contact with eyes, you should rinse immediately with plenty of water and seek medical advice. Whenever you will contact it, please wear suitable protective clothing.

You can still convert the following datas into molecular structure:
(1)Canonical SMILES: CN(C)CCN(CC1=CC=CC=C1)C2=CC=CC=N2.Cl
(2)InChI: InChI=1S/C16H21N3.ClH/c1-18(2)12-13-19(16-10-6-7-11-17-16)14-15-8-4-3-5-9-15;/h3-11H,12-14H2,1-2H3;1H
(3)InChIKey: FSSICIQKZGUEAE-UHFFFAOYSA-N

The toxicity data is as follows:

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Effect	Source
dog	LDLo	intravenous	20mg/kg (20mg/kg)		Arzneimittel-Forschung. Drug Research. Vol. 19, Pg. 1916, 1969.
dog	LDLo	oral	23mg/kg (23mg/kg)	LUNGS, THORAX, OR RESPIRATION: DYSPNEA BEHAVIORAL: MUSCLE CONTRACTION OR SPASTICITY) BEHAVIORAL: EXCITEMENT	Bulletin of the Johns Hopkins Hospital. Vol. 81, Pg. 55, 1947.
guinea pig	LD50	oral	150mg/kg (150mg/kg)		Journal of Allergy. Vol. 27, Pg. 57, 1956.
guinea pig	LD50	subcutaneous	30mg/kg (30mg/kg)	BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD BEHAVIORAL: MUSCLE CONTRACTION OR SPASTICITY) BEHAVIORAL: TREMOR	Journal of Pharmacology and Experimental Therapeutics. Vol. 113, Pg. 72, 1955.
hamster	LD50	intravenous	13mg/kg (13mg/kg)	BEHAVIORAL: EXCITEMENT BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD BEHAVIORAL: TREMOR	Journal of Pharmacology and Experimental Therapeutics. Vol. 97, Pg. 371, 1949.
man	LDLo	unreported	15mg/kg (15mg/kg)		"Poisoning; Toxicology, Symptoms, Treatments," 2nd ed., Arena, J.M., Springfield, IL, C.C. Thomas, 1970Vol. 2, Pg. 73, 1970.
mouse	LD50	intraperitoneal	47mg/kg (47mg/kg)	BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD	Clinical Toxicology. Vol. 16, Pg. 17, 1980.
mouse	LD50	intravenous	9mg/kg (9mg/kg)	BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION PERIPHERAL NERVE AND SENSATION: FLACCID PARALYSIS WITHOUT ANESTHESIA (USUALLY NEUROMUSCULAR BLOCKAGE)	Journal of Pharmacology and Experimental Therapeutics. Vol. 92, Pg. 249, 1948.
mouse	LD50	oral	97mg/kg (97mg/kg)		Journal of Pharmacology and Experimental Therapeutics. Vol. 99, Pg. 488, 1950.
mouse	LD50	subcutaneous	41mg/kg (41mg/kg)	BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) BEHAVIORAL: TREMOR	Journal of Pharmacology and Experimental Therapeutics. Vol. 113, Pg. 72, 1955.
rabbit	LD50	intravenous	9mg/kg (9mg/kg)	BEHAVIORAL: EXCITEMENT BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD	Journal of Laboratory and Clinical Medicine. Vol. 31, Pg. 749, 1946.
rabbit	LD50	subcutaneous	33mg/kg (33mg/kg)	BEHAVIORAL: EXCITEMENT BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD	Journal of Laboratory and Clinical Medicine. Vol. 31, Pg. 749, 1946.
rat	LD50	intravenous	12mg/kg (12mg/kg)	BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD BEHAVIORAL: EXCITEMENT	Journal of Laboratory and Clinical Medicine. Vol. 31, Pg. 749, 1946.
rat	LD50	oral	469mg/kg (469mg/kg)		Journal of Pharmaceutical Sciences. Vol. 69, Pg. 1198, 1980.
rat	LD50	subcutaneous	75mg/kg (75mg/kg)		Proceedings of the Society for Experimental Biology and Medicine. Vol. 78, Pg. 708, 1951.