Reference

Some indexes of riboflavin metabolism after administration of thiamin derivatives to animals

Some indexes of riboflavin metabolism after administration of thiamin derivatives to animals. Dosta, G. A. (USSR). Vzaimootnoshenie Vodorastvorimykh Vitam. Uchastie Ikh Obmene Veshchestv Patol. Protsessakh, 18-23. Edited by: Lukashik, N. K. Grodn. Gos. Med. Inst.: Grodno, USSR. (Russian) 1983. CODEN: 52UZAG. DOCUMENT TYPE: Conference CA Section: 18 (Animal Nutrition) Thiamin diphosphate [154-87-0] or thiochrome [92-35-3] introduced s.c. at therapeutic doses (2.5 mg/kg for 10 days) to rats did not significantly affect riboflavin [83-88-5] metab. by the liver: the levels of riboflavin, FAD [146-14-5], and FAD-dependent enzymes (succinate- [9002-02-2], NADH- [9079-67-8], and NADPH- [9001-68-7] dehydrogenases) were similar to those in untreated controls. Thiamin monophosphate [495-23-8] or oxythiamin [136-16-3] at the same doses increased liver riboflavin, FAD, and FAD-dependent enzyme levels.

Adaptive processes during development of thiamin deficiency

Adaptive processes during development of thiamin deficiency. Tumanov, V. N.; Trebukhina, R. V.; Ostrovskii, Yu. M. (Otd. Regul. Obmena Veshchestv, USSR). Vopr. Pitan., (5), 39-42 (Russian) 1984. CODEN: VPITAR. ISSN: 0042-8833. DOCUMENT TYPE: Journal CA Section: 18 (Animal Nutrition) Mice raised on a thiamin [59-43-8]-deficient diet from body wt. 22-24 g for 21 days showed gradual decreases in blood transketolase [9014-48-6] (with redistributions of halo and apo forms), similar decreases in liver thiamin diphosphate [154-87-0], and increases in liver thiamin phosphokinase [62213-38-1] and thiamin pyrophosphatase [9038-53-3]. Thiamin diphosphate also decreased in other organs (kidney, spleen, heart, and to a lesser extent brain), muscle, and blood.