Detail of "15421-84-8"

Reference

Effects of antiplatelet agents on pulmonary metastases

Effects of antiplatelet agents on pulmonary metastases. Bando, Hiroyasu; Yamashita, Takashi; Tsubura, Eiro (Sch. Med., Univ.Chemicals with cas numbers 58-32-2 and 55142-85-3 also play role. Tokushima, Tokushima 770, Japan). Gann, 75(3), 284-91 (English) 1984. CODEN: GANNA2. ISSN: 0016-450X. DOCUMENT TYPE: Journal CA Section: 1 (Pharmacology) Section cross-reference(s): 14 The role of platelets in cancer metastasis was studied by investigating the effects of the antiplatelet agents ticlopidine [55142-85-3], diltiazem [42399-41-7], dipyridamole [58-32-2] and trapidil [15421-84-8] on artificial and spontaneous pulmonary metastases in mice. These agents were tested at their optimal inhibitory doses on ADP-induced platelet aggregation; namely, 100 mg/kg for ticlopidine, 2 mg/kg for diltiazem, 180 mg/kg for trapidil and 60 mg/kg for dipyridamole. At these doses, trapidil caused moderate inhibition of thrombin-induced platelet aggregation in mice, but the other agents had only slight effects. Artificial pulmonary metastasis was produced by inoculation of Lewis lung carcinoma (LLC) or B16 melanoma (B16) cells into C57BL/6 mice. For induction of spontaneous pulmonary metastases, these tumor cells were implanted s.c. into the footpads of mice. The resulting primary tumors of LLC and B16 were removed 9-10 and 17 days later, resp. Artificial pulmonary metastases were inhibited significantly by all the antiplatelet agents tested. Spontaneous pulmonary metastases were markedly reduced only when these agents were given after removal of the primary tumor. The role of platelets is discussed with respect to thrombus formation in the lodgement of tumor cells and the participation of platelet-derived growth factor in the growth of metastatic foci. .

PGI2 and TXA2 syntheses from arachidonic acid in isolated glomeruli

PGI2 and TXA2 syntheses from arachidonic acid in isolated glomeruli. Osamura, Kichiro; Rin, Kenhiro; Tsuji, Hajime; Mikami, Kinji; Toyoda, Takeo; Kanayama, Shunyo; Okano, Ryo; Kaimasu, Isao; Nakagawa, Masao; Ijichi, Hamao (Second Dep. Intern. Med., Kyoto Prefect. Univ. Med., Kyoto, Japan). Ketsueki to Myakkan, 14(4), 491-3 (Japanese) 1983. CODEN: KTMYA3. ISSN: 0386-9717. DOCUMENT TYPE: Journal CA Section: 2 (Mammalian Hormones) PGI2 [35121-78-9] and TXA2 [57576-52-0] syntheses from arachidonic acid [506-32-1] in glomeruli isolated from rat kidney were investigated. TXB2 [54397-85-2] prodn. was increased by addn. of arachidonic acid, but synthesis of 6-keto-PGF1a [58962-34-8] was only slightly increased. The recovery of added TXB2 in the presence of indomethacin was almost 100%. On the contrary, the recovery of added 6-keto-PGF1a was remarkably reduced. 6-Keto-PGF1a may be metabolized further in the glomeruli. TXA2 synthesis was inhibited by addn. of aspirin, indomethacin, and OKY 1581. Dipyridamole [58-32-2] slightly inhibited TXA2 prodn. in vitro and in vivo, but increased PGI2 prodn. in vivo, whereas Trapidil [15421-84-8] inhibited TXA2 prodn. in vivo and remarkably increased PGI2 prodn. in vivo.