Detail of "15439-16-4"

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Investigations of N-linked macrocycles for indium-111 and yttrium-90 labeling of proteins

Investigations of N-linked macrocycles for indium-111 and yttrium-90 labeling of proteins. Wu, C.; Virzi, F.; Hnatowich, D. J. (Med. Cent., Univ. Massachusetts, Worcester, MA 01655, USA).Some commonly used reagents like 60239-18-1 and 15439-16-4 are used in this experiment. Nucl. Med. Biol., 19(2), 239-44 (English) 1992. CODEN: NMBIEO. ISSN: 0883-2897. DOCUMENT TYPE: Journal CA Section: 8 (Radiation Biochemistry) To simplify the synthesis of macrocyclic chelators, com. available macrocyclic amines were condensed with halogenated acetic acid to prep. the 5 chelators 12N4 (DOTA), 14N4 (TETA), 15N4, 9N3, and 12N3. Only 12N4 and 9N3 showed efficient labeling of the free chelator with 111In and 90Y. Serum stability studies at 37° with In-labeled DTPA, 12N4, and 9N3 showed no loss of label over 2 days whereas, with 90Y, only 12N4 showed stabilities comparable to DTPA. The 12N4 chelator was derivatized by attaching biotin on one N-acetate group to simulate the attachment to protein. The serum stability for both 111In and 90Y was identical to that of biotin-derivatized DTPA and lower than that of the free chelators. Biodistribution studies in normal mice of a model protein (avidin) labeled with 90Y via biotinylated 12N4 and biotinylated DTPA showed identical distribution at 1 day except in bone where the %ID/g for the macrocyclic-conjugated protein (3.4) was lower than that of the DTPA-conjugated protein (9.4). In conclusion, macrocycles may be readily synthesized from the macrocyclic amines and several show useful stabilities with In and Y. When N-linked to a protein, the Y biodistribution was found to be superior to that of the corresponding DTPA-coupled protein. .

Reduction catalysts for dinitrogen oxide removal from waste gases

Reduction catalysts for dinitrogen oxide removal from waste gases. Taniguchi, Isao (Chisso Corp., Japan). Jpn. Kokai Tokkyo Koho JP 03254816 A2 13 Nov 1991 Heisei, 5 pp. (Japan). CODEN: JKXXAF. CLASS: ICM: B01D053-34. ICS: B01J031-22; C25B001-00. APPLICATION: JP 90-51467 2 Mar 1990. DOCUMENT TYPE: Patent CA Section: 59 (Air Pollution and Industrial Hygiene) Section cross-reference(s): 67 The title catalysts comprise metal complexes of macrocyclic polyamines of formula Mp(CnH2nN4H4)Xm [M is a cation of Cu, Co, Ni, W, Mo and Fe; X is 31 of halogen ions and ClO4-; n is an integer of 9-12; m and p are pos. integers, but (the valence of M) ′ p = (the valence of X) ′ m] in an aq. soln. contg. electrolytes. The electrolytes are 31 halides, sulfates, sulfites, nitrates, nitrides, carbonates and phosphates of alkali metals, alk. earth metals, Fe, Co, Ni, Cu, and Zn ions. The temp. and elec. potential applied in the electrolysis bath are controlled at 0-60° and -0.In this experiment, several chemicals are used like 15439-16-4 and 295-37-4 5 to -2.0 V, resp. Suitable macrocyclic polyamines include 1,4,8,10-tetrazacyclopentadecane, 1,4,8,11-tetrazacyclotetradecane, and 1,5,9,13-tetrazacyclohexadecane. .