Detail of "15532-75-9"

CAS Number:
15532-75-9
Name:
N-(3-Trifluoromethylphenyl)piperazine
Molecular Structure:
Formula:
C₁₁H₁₃F₃N₂
Molecular Weight:
230.23
Synonyms:
Piperazine,1-(a,a,a-trifluoro-m-tolyl)- (8CI);1-(a,a,a-Trifluoro-m-tolyl)piperazine;1-[m-(Trifluoromethyl)phenyl]piperazine;4-[3-(Trifluoromethyl)phenyl]piperazine;N-(m-Trifluoromethylphenyl)piperazine;N-(a,a,a-Trifluoro-m-tolyl)piperazine;NSC 128882;TFMPP;TFTP;m-Trifluoromethylphenylpiperazine;
EINECS:
239-574-4
Density:
1.203 g/cm³
Boiling Point:
305.9 ºC at 760 mmHg
Flash Point:
138.8 °C
Appearance:
clear colourless to yellow slightly viscous liquid
Hazard Symbols:
Xi,C
Risk Codes:
36/37/38
Safety:
26-36 Details

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Reference

Evidence that blood pressure reduction by serotonin antagonists is related to alpha receptor blockade in spontaneously hypertensive rats: Evidence that blood pressure reduction by serotonin antagonists is related to alpha receptor blockade in spontaneously hypertensive rats. Cohen, Marlene L.; Fuller, Ray W.; Kurz, Ken D. (Lilly Res. Lab., Eli Lilly and Co., Indianapolis, IN 46285, USA). Hypertension (Dallas), 5(5), 676-81 (English) 1983. CODEN: HPRTDN. ISSN: 0194-911X. DOCUMENT TYPE: Journal CA Section: 1 (Pharmacology) In vitro affinity for vascular serotonin (5HT2) and a-receptors was detd. for several compds. (spiperone [749-02-0], ketanserin [74050-98-9], mianserin [24219-97-4], trazodone [19794-93-5], mepiprazole [20326-12-9], benzoctamine [17243-39-9], m-trifluoromethylphenylpiperazine [15532-75-9], m-chlorophenylpiperazine [6640-24-0], and 1-(1-naphthyl)piperazine) [57536-86-4] known to interact with serotonin receptors. All compds. competitively inhibited 5HT2 and a-receptors with differing degrees of selectivity. Based on these observations, ketanserin, benzooctamine, and 1-(1-naphthyl)piperazine were evaluated as antihypertensive agents in spontaneously hypertensive rats (SHR). Of these compds., 1-(1-naphthyl)piperazine was a highly selective 5HT2 receptor antagonist with a ratio of 5HT2 to a-receptor affinity of > 2000. The ratio of 5HT2 to a-receptor affinity for ketanserin and benzoctamine was 63 and 16, resp. However, the order of affinity toward 5HT2 receptors was ketanserin > 1-(1-naphthyl)piperazine > benzoctamine, whereas the order of affinity toward a-receptors was ketanserin > benzoctamine > 1-(1-naphthyl)piperazine. A similar order of potency toward both 5HT2 and a-receptors was found in pithed SHR based on antagonism of the pressor response to serotonin and methoxamine, resp. In the SHR, max. blood pressure redn. at a dose of 10 mg/kg i.p. was approx. 65 and 30 mm Hg for ketanserin and benzooctamine, resp.; 1-(1-naphthyl)piperazine did not affect blood pressure.In this experiment, several chemicals are used like 24219-97-4 and 6640-24-0 Thus, blood pressure redn. more closely paralleled the in vitro and in vivo potency of these agents toward vascular a-rather than 5HT2 receptors. Apparently, a-blockade rather than selective 5HT2 receptor blockade is responsible for the antihypertensive activity of "serotonergic antagonists" in the SHR. .

Calcium-dependency of the pressor responses to selective 5-hydroxytryptamine receptor agonists in pithed rats: Calcium-dependency of the pressor responses to selective 5-hydroxytryptamine receptor agonists in pithed rats. Kalkman, H. O.; Boddeke, H. W. G. M.; Timmermans, P. B. M. W. M.; Van Zwieten, P. A. (Dep. Pharm., Univ. Amsterdam, Amsterdam 1018 TV, Neth.). J. Auton. Pharmacol., 3(4), 281-6 (English) 1983. CODEN: JAPHDU. ISSN: 0144-1795. DOCUMENT TYPE: Journal CA Section: 2 (Mammalian Hormones) The pressor responses to 6 selective 5-HT receptor agonists, quipazine [4774-24-7], TFMPP (I) [15532-75-9], Org 10155 (II) [81078-82-2], Ru 24969 [66611-26-5], 5-methoxytryptamine [608-07-1], and 5-methoxy-N,N-dimethyltryptamine (III) [1019-45-0], were quantified and tested for Ca dependency following i.v. administration to pithed normotensive rats. The pressor responses induced by 5-methoxytryptamine and III were not influenced by Ca2+ entry blockade with nifedipine. The piperazine derivs. quipazine, I, and II were full agonists, but the pressor responses to these agonists were sensitive to Ca2+ entry blockade. III and Ru 24969 were partial agonists. Within the present series of 5-HT receptor agonists, a restricted side chain flexibility may enhance the dependency of their pressor responses to extracellular Ca2+.

Detail of "15532-75-9"

N-(3-Trifluoromethylphenyl)piperazine

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CAS No.15532-75-9 N-(3-Trifluoromethylphenyl)piperazine

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CAS No.15532-75-9 N-(3-Trifluoromethylphenyl)piperazine

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CAS No.15532-75-9 N-(3-Trifluoromethylphenyl)piperazine

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CAS No.15532-75-9 N-(3-Trifluoromethylphenyl)piperazine

CAS No.15532-75-9 N-(3-Trifluoromethylphenyl)piperazine

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CAS No.15532-75-9 N-(3-Trifluoromethylphenyl)piperazine

CAS No.15532-75-9 N-(3-Trifluoromethylphenyl)piperazine

CAS No.15532-75-9 N-(3-Trifluoromethylphenyl)piperazine

Reference