Reference

Activated, stabilized enzymes useful for wound healing

Activated, stabilized enzymes useful for wound healing. Bilton, Gerald L. (Hafsten, Raymond, J., Jr., USA). PCT Int. Appl. WO 8402274 A1 21 Jun 1984, 21 pp. DESIGNATED STATES: W: JP; RW: AT, BE, CH, DE, FR, GB, LU, NL, SE. (English). (World Intellectual Property Organization). CODEN: PIXXD2. CLASS: IC: A61K037-62. APPLICATION: WO 83-US1922 7 Dec 1983. PRIORITY: US 82-448154 9 Dec 1982. DOCUMENT TYPE: Patent CA Section: 63 (Pharmaceuticals) A stable enzyme compn. contains proteolytic enzymes in an amt. effective to produce a fibrinolytic effect at a wound site, an amt. of starch [9005-25-8] effective to immobilize the enzymes, amino acids, and a raw gland or organ conc. Part A of a compn. was prepd. contg. thymus substance 1.5, spleen substance 1.5 L-arginine HCl [15595-35-4] 0.5, L-lysine-HCl [10098-89-2] 0.5, DL-methionine [59-51-8] 0.5, L-glutamic acid [56-86-0] 0.5, L-leucine [61-90-5] 0.5, glutatione [70-18-8] 0.5, and L-arginine-L-glutamate [4320-30-3] 0.5 kg. Part B contained pancreatin [8049-47-6] 5.7, papain [9001-73-4] 7.3, bromolain [9001-00-7] 5.8, ficin [9001-33-6] 2.0, trypsin [9002-07-7] 0.3 and chymotrypsin [9004-07-3] 0.7 kg. Part C contained Mg stearate 1.5, alginic acid 1.5, Ca bicarbonate 1.5, starch 3.0 and CaHPO4 33.8 kg. Part A was mixed at low humidity and ingredients of Part B sequentially added while lightly spraying 7.4 g of 24.0 mL refined food glaze in 16.7 mL iso-PrOH. Part C ingredients were then added and the powd. compn. compressed into tablets and enteric coated.

Protective effect of arginine in hyperoxia

Protective effect of arginine in hyperoxia. Activity of glutaminase and glutamate decarboxylase in the brain. Krichevskaya, A. A.; Shugalei, V. S.; Tsvetnenko, E. Z.; Ananyan, A. A. (Rostov State Univ., Rostov-on-Don, USSR). Vopr. Med. Khim., 24(1), 42-6 (Russian) 1978. CODEN: VMDKAM. ISSN: 0042-8809. DOCUMENT TYPE: Journal CA Section: 3 (Biochemical Interactions) Hyperoxia (6 atm.) decreased the activities of phosphate-dependent and phosphate-independent glutaminase [9001-47-2] and glutamate decarboxylase [9024-58-2] in the rat cerebral cortex by 45, 51, and 32%, resp. When injected 30 min before induction of hyperoxia, L-arginine-HCl [15595-35-4] (100 mg/100 g, i.p.) delayed the development of O spasms and increased the brain glutamate dehydrogenase activity to 29% above the normal level. Glutaminase activity was unaffected by arginine.