Reference

Inhibition of partially purified rat brain sodium-potassium-dependent ATPase by bile acids, phenolic acids and endotoxin

Inhibition of partially purified rat brain sodium-potassium-dependent ATPase by bile acids, phenolic acids and endotoxin. Seda, H. W. M.; Gove, C. D.; Hughes, R. D.; Williams, Roger (Liver Unit, King's Coll. Hosp., London, UK). Clin. Sci., 66(4), 415-20 (English) 1984. CODEN: CSCIAE. ISSN: 0143-5221. DOCUMENT TYPE: Journal CA Section: 4 (Toxicology) Section cross-reference(s): 14 Chenodeoxycholic acid [474-25-9], p-hydroxyphenyllactic acid (I) [306-23-0], p-hydroxyphenylpyruvic acid [156-39-8], and endotoxin caused 30-45% inhibition of partially purified rat brain Na+, K+-dependent ATPase [9000-83-3] at concns. known to occur in the serum of patients with fulminant hepatic failure (FHF). At low concns. the inhibitory effects of these substances were additive, but at higher concns. a max. level of inhibition was reached. 640-79-9 and 156-38-7 are just another two chemicals used in this study. Thus, these substances are likely, of importance in altered brain function found in FHF. .

Effects of dietary protein level and ascorbic acid supplementation on the contents of tyrosine metabolites in droppings and plasma of chicks fed a diet containing excess tyrosine

Effects of dietary protein level and ascorbic acid supplementation on the contents of tyrosine metabolites in droppings and plasma of chicks fed a diet containing excess tyrosine.Some chemicals with cas registry numbers like 3233-32-7 and 306-23-0 are also used. Yanaka, Masao; Okumura, Junichi (Fac. Agric., Nagoya Univ., Nagoya 464, Japan). Poult. Sci., 62(12), 2433-41 (English) 1983. CODEN: POSCAL. ISSN: 0032-5791. DOCUMENT TYPE: Journal CA Section: 18 (Animal Nutrition) Chicks fed a 10% protein diet with excess tyrosine [60-18-4] developed external foot lesions accompanied by retarded growth and depressed food intake. These adverse effects were alleviated by elevating dietary protein level or supplementing with ascorbic acid (I) [50-81-7]. Excreta and plasma of chicks fed the 10% protein diet contained small or undetectable amts. of free tyrosine, 4-hydroxyphenylpyruvate (II) [156-39-8], 4-hydroxyphenyllactate (III) [306-23-0], and 4-hydroxyphenylacetate (IV) [3233-32-7], while these metabolites were markedly increased by the addn. of excess tyrosine to the 10% protein diet. From the results with colostomized cocks, the major source of II, III, and IV excreted by chicks fed a tyrosine excess diet was considered more likely to be of urinary than fecal origin. Elevated contents of tyrosine and its metabolites in plasma were partially counteracted by increasing dietary protein level or I supplementation. In excreta contents of tyrosine and its metabolites caused by excess tyrosine were reduced by increasing dietary protein level and supplementing with I when expressed in the proportion of tyrosine intake. These results suggest that the beneficial effects of increased dietary protein level and supplementation with I are related to enhanced ability of chicks to degrade excessively ingested tyrosine. .