Reference

Effect of para-methoxyphenylethylamine and its derivatives on rat male-to-male mounting behavior

Effect of para-methoxyphenylethylamine and its derivatives on rat male-to-male mounting behavior. Segal, Mark; Edelstein, Eliezer; Dikstein, Shabtay (Dep. Psychiatry, Hadassah Med. Organ., Jerusalem, Israel). Res. Commun. Psychol., Psychiatry Behav., 2(3-4), 161-77 (English) 1977. CODEN: RCPBDC. DOCUMENT TYPE: Journal CA Section: 1 (Pharmacodynamics) Section cross-reference(s): 13 Of the 21 compds. tested, only several phenylethylamine analogs, p-chlorophenylethylamine [156-41-2], p-methoxyphenylethylamine [55-81-2], 3,4-dimethoxyphenylethylamine [120-20-7] and p-ethoxyphenethylamine [62885-82-9] were synergistic with a subliminal dose of p-chlorophenylalanine [1991-78-2] in inducing male-to-male mounting behavior in sexually naive rats. P-methoxyphenylethylamine and 3,4-dimethoxyphenylethylamine when administered alone chronically also induced such behavior. The reported data indicate that both synthetic and naturally occurring amines can induce male-to-male mounting behavior in rats and it is speculated that their action is mediated by influencing neurotransmitter uptake and/or release.

Effects of p-chloro-

Effects of p-chloro-.beta.-phenylethylamine on the uptake and release of putative amine neurotransmitters in rat brain. Baker, G. B.; Bertollini, A.; Del Carmine, R.; Martin, I. L.; Raiteri, M. (Med. Res. Counc. Neuropharmacol. Unit, Med. Sch., Birmingham, Engl.). Br. J. Pharmacol., 58(3), 420P-421P (English) 1976. CODEN: BJPCBM. DOCUMENT TYPE: Journal CA Section: 1 (Pharmacodynamics) In crude synaptosomal P2 fractions prepd. from rat hypothalamus or striatum, p-chloro-.beta.-phenylethylamine (I) [156-41-2] inhibited 5-hydroxytryptamine [50-67-9], noradrenaline [51-41-2], and dopamine [51-61-6] uptake with 50% inhibitory concns. of 2.2 .times. 10-6, 5.0 .times.There are some commonly used reagents with their cas registry numbers 156-41-2 and 50-67-9 in this article. 10-6, and 1.5 .times. 10-5M. Marked differences were also found in its effect on the release of these transmitters, and I was an esp. strong stimulator of 5-hydroxytryptamine release. By comparison with the effects of .beta.-phenylethylamine the p-chloro substituent was shown to have little effect on noradrenaline release, but dramatically increased 5-hydroxytryptamine and decreased dopamine release. .