Detail of "15646-46-5"

Reference

Induction of contact sensitivity to a broad variety of allergens with haptenized macrophages

Induction of contact sensitivity to a broad variety of allergens with haptenized macrophages. Von Blomberg-Van der Flier, Mary; Scheper, Rik J.; Boerrigter, Gijs H.; Polak, Ladislav (Dep. Pathol., Free Univ. Hosp., Amsterdam 1007 MB, Neth.). J. Invest. Dermatol., 83(2), 91-5 (English) 1984. CODEN: JIDEAE. ISSN: 0022-202X. DOCUMENT TYPE: Journal CA Section: 4 (Toxicology) Using guinea pigs an anal. could be made of various aspects of contact sensitivity (CS) induced by s.c. injection of syngeneic haptenized macrophages [oil-induced peritoneal exudate cells (PEC)] as compared to epicutaneous sensitization. Very little PEC-bound hapten (dinitrochlorobenzene [97-00-7], or oxazolone [15646-46-5]) is needed for optimum sensitization. Nevertheless, both sensitization methods induce a state of CS that may last for >6 mo, give rise to hapten-specific antibodies with a similar isotype distribution, and show susceptibility to cyclophosphamide [50-18-0] pretreatment. In addn., time courses and microscopic appearance of skin test reactions after either way of sensitization are identical. CS to a broad variety of physicochem. different antigens, including Ni, penicillin G [61-33-6], and acrylates, is readily induced by syngeneic PEC, haptenized following a standardized procedure. As Freund's complete adjuvant is known to cause serious side effects like ulceration and long-lasting granuloma formation, immunization with haptenized PEC should now be considered as a clean and effective alternative in exptl. CS studies.

Pharmacological comparison of the immune and non-immune inflammations induced by picryl chloride and oxazolone in mice

Pharmacological comparison of the immune and non-immune inflammations induced by picryl chloride and oxazolone in mice. Tarayre, J. P.; Aliaga, M.; Villanova, G.; Barbara, M.; Caillol, V.; Bru, M.; Lauressergues, H. (Dep. Pharmacol., Cent. Rech. P. Fabre, Castres 81106, Fr.). Arch. Int. Pharmacodyn. Ther., 269(1), 153-66 (English) 1984. CODEN: AIPTAK. ISSN: 0003-9780. DOCUMENT TYPE: Journal CA Section: 1 (Pharmacology) Section cross-reference(s): 2, 14 Picryl chloride [88-88-0] applied to the ears of mice induced primary irritation inflammation (maximal after 3 to 6 h); after contact sensitization performed 7 days before, a delayed hypersensitivity reaction was obsd. with the compd. Oxazolone [15646-46-5] produced only a weak primary irritation reaction. After contact sensitization under the same conditions as above, oxazolone induced an immune response that was already substantial 3 to 6 h after the challenge and generally reached a max. after 24 h. Cutaneously applied mepyramine maleate [59-33-6], methysergide bimaleate [129-49-7], cimetidine [51481-61-9], cromoglycic acid [16110-51-3], phenylbutazone [50-33-9] and acetylsalicylic acid [50-78-2] reduced to varying degrees the primary irritation and the delayed hypersensitivity inflammation induced by picryl chloride. Only methysergide clearly reduced the immune response to oxazolone (decrease in the 6-h phase). After systemic administration, these same drugs had no effect on the 4 types of reaction. Both corticosteroids tested (hydrocortisone acetate [50-03-3] and desonide [638-94-8]) reduced all the inflammations to various degrees and were always more active (particularly desonide) when applied topically than when administered systemically. On the other hand indomethacin [53-86-1], which inhibited all types of inflammation, was more active when administered systemically. Thus, the various reactions induced by picryl chloride and oxazolone in mice are pharmacol. different.