Detail of "15690-38-7"

Reference

Method for manufacturing cefuroxime

Method for manufacturing cefuroxime. Choi, Il Gyun; Kim, Ho Jin; Kim, Sang Rin; Lee, In Gyu; Park, Se Chung (Boryung Pharmaceutical Co., Ltd., S. Korea). Repub. Korean Kongkae Taeho Kongbo KR 2002011254 A 8 Feb 2002, No pp. given (Korean). (Korea, Republic Of). CODEN: KRXXA7. CLASS: ICM: C07D501-06. APPLICATION: KR 2000-44631 1 Aug 2000. DOCUMENT TYPE: Patent CA Section: 26 (Biomolecules and Their Synthetic Analogs) Provided is a method for easily manufg. cefuroxime in high purity and yield by manufg. cryst. cefuroxime sodium then treating it with inorg. acid in the presence of a mixed solvent of water and org. solvent. The cefuroxime represented by the formula(2) is manufd. by dissolving 7-amino-3-hydroxymethylcephalosphoranic acid in inorg. salt soln., in the range of pH 6-7; acylating the resultant compd. with 2-(furyl-2-yl)-2-methoxyiminoacetic chloride to obtain a cephalosporin deriv. of the formula(1) as an intermediate; carbamoylating hydroxy group at C-3 of the intermediate compd.In this experiment, several chemicals are used like 55268-75-2 and 15690-38-7 with isocyanate compd. of the formula(4): R-NCO in the range of less than pH 1; then hydrolyzing it to obtain cefuroxime of the formula(2). In the formula(4), R is a protecting group selected from chlorosulfonyl group, trichloroacethyl group, trimethylsilyl group, bromo sulfonyl group, dichloroacethyl group, 2,2,2-trichloroethoxycarbonyl, dihalophosphinyl group and dimethoxyphosphinyl group. .

7-Acylamino-3-vinylcephalosporanic acid derivatives

7-Acylamino-3-vinylcephalosporanic acid derivatives. Takaya, Takao; Takasugi, Hisashi; Masugi, Takashi; Yamanaka, Hideaki; Kawabata, Kohji (Fujisawa Pharmaceutical Co., Ltd. , Japan). U.S. US 4423213 A 27 Dec 1983, 80 pp. Cont.-in-part of U. 15690-38-7 which is the cas registry number is also used here.S. Ser. No. 205,334. (English). (United States of America). CODEN: USXXAM. CLASS: IC: C07D501-22. NCL: 544016000. APPLICATION: US 81-261618 7 May 1981. PRIORITY: GB 79-39985 19 Nov 1979; GB 80-4335 8 Feb 1980; GB 80-12991 21 Apr 1980; GB 80-22920 14 Jul 1980; US 80-205334 10 Nov 1980. DOCUMENT TYPE: Patent CA Section: 26 (Biomolecules and Their Synthetic Analogs) Section cross-reference(s): 1, 10 Cephalosporins I [X = CO, protected CO; R = halogen; R1 = H, cycloalkenyl, (un)substituted alkenyl, alkyl, heterocyclic; R2 = H, protective group] were prepd. Thus, benzhydryl 7-amino-3-vinyl-3-cephem-4-carboxylate.HCl was prepd. from cephalosporin C in 6 steps and was acylated with BrCH2COC(:NOMe)CO2H to give I (R = Br, R1 = Me, R2 = CHPh2, X = CO) which was cyclized with thiourea and hydrolyzed to give the thiazolylacetamidocephem II. II had a min. inhibitory concn. against Proteus mirabilis of 0.05 mg/mL. .