CAS No.1585-90-6,1-(2-HYDROXY-ETHYL)-PYRROLE-2,5-DIONE Suppliers

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Basic Information

Molecular Structure:
CAS No.:	1585-90-6
Name:	1-(2-HYDROXY-ETHYL)-PYRROLE-2,5-DIONE
Article Data:	28

Formula:	C₆H₇NO₃
Molecular Weight:	141.126
Synonyms:	N-(2-Hydroxyethyl)maleimide;2-Hydroxyethyl maleimide;1-(2-Hydroxyethyl)pyrrole-2,5-dione;Maleimide,N-(2-hydroxyethyl)- (7CI,8CI);
Density:	1.395 g/cm³
Melting Point:	70-71℃
Boiling Point:	304.5 °C at 760 mmHg
Flash Point:	138 °C
Hazard Symbols:	Xn
Risk Codes:	22-36
Safety:	26
PSA:	57.61000
LogP:	-1.15840

Synthetic route

: 4-(2-hydroxyethyl)-10-oxa-4-azatricyclo[5.2.1.02,6]dec-8-ene-3,5-dione

: 1585-90-6
1-(2-hydroxyethyl)-1H-pyrrole-2,5-dione

Conditions

Conditions	Yield
In toluene at 110℃; Inert atmosphere;	99%
In toluene at 110℃; for 5h; Inert atmosphere;	28%
In toluene Reflux;

: 32620-90-9
4-(2-hydroxy-ethyl)-10-oxa-4-aza-tricyclo[5.2.1.02,6]dec-8-ene-3,5-dione

: 1585-90-6
1-(2-hydroxyethyl)-1H-pyrrole-2,5-dione

Conditions

Conditions	Yield
With 1,4-dimethoxybezene In xylene at 130℃; for 3.25h; Heating / reflux;	93%
In toluene at 105℃; for 16h;	92%
In toluene at 120℃;	82%

: 108-31-6
maleic anhydride

: 141-43-5
ethanolamine

: 1585-90-6
1-(2-hydroxyethyl)-1H-pyrrole-2,5-dione

Conditions

Conditions	Yield
With sulfuric acid; copper(II) sulfate; sodium sulfate In 5,5-dimethyl-1,3-cyclohexadiene at 140℃; for 2h;	88%
Stage #1: maleic anhydride; ethanolamine In acetone at 20℃; for 1h; Stage #2: With sodium acetate; triethylamine; hydroquinone at 115℃; for 2.5h;	30%
In toluene at 80℃; for 2h;	25%

: 1585-79-1
2-(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)ethyl acetate

: 1585-90-6
1-(2-hydroxyethyl)-1H-pyrrole-2,5-dione

Conditions

Conditions	Yield
With toluene-4-sulfonic acid In methanol; water for 72h; Heating;	81%

: 55750-48-6
N-methoxycarbonylmaleimide

: 141-43-5
ethanolamine

: 1585-90-6
1-(2-hydroxyethyl)-1H-pyrrole-2,5-dione

Conditions

Conditions	Yield
With sodium hydrogencarbonate at 0 - 25℃;	75%
With sodium hydrogencarbonate In water	63%

: C10H11NO4

: 1585-90-6
1-(2-hydroxyethyl)-1H-pyrrole-2,5-dione

Conditions

Conditions	Yield
In toluene for 10h; Reflux;	54%

: 1585-93-9
2-[(3-carboxy-1-oxo-2-propenyl)amino]-ethanol

: 1585-90-6
1-(2-hydroxyethyl)-1H-pyrrole-2,5-dione

Conditions

Conditions	Yield
With sodium acetate; acetic anhydride at 70℃;	35%
With sulfuric acid at 60℃;

: 15519-86-5
N-(2-Hydroxyethyl)-maleinsaeureamid

: 1585-90-6
1-(2-hydroxyethyl)-1H-pyrrole-2,5-dione

Conditions

Conditions	Yield
With triethylamine In toluene for 2h; Heating;	14%

: 6719-02-4
2-(1H-pyrrol-1-yl)ethanol

A: 1585-90-6
1-(2-hydroxyethyl)-1H-pyrrole-2,5-dione

B: 1186033-58-8
2,3-dihydropyrrolo[2,1-b]oxazol-5(7ah)-one

C: 1186033-59-9
5-hydroxy-1-(2-hydroxyethyl)-1H-pyrrol-2(5H)-one

Conditions

Conditions	Yield
With water; oxygen; 5,15,10,20-tetraphenylporphyrin In tetrachloromethane at 0℃; Irradiation;
With decatungstate(4-); water; oxygen In acetonitrile at 0℃; Irradiation;

...Expand

: 6719-02-4
2-(1H-pyrrol-1-yl)ethanol

: 67-56-1
methanol

A: 1585-90-6
1-(2-hydroxyethyl)-1H-pyrrole-2,5-dione

B: 1186033-58-8
2,3-dihydropyrrolo[2,1-b]oxazol-5(7ah)-one

C: 1186033-59-9
5-hydroxy-1-(2-hydroxyethyl)-1H-pyrrol-2(5H)-one

D: 1186033-60-2
1-(2-hydroxyethyl)-5-methoxy-1H-pyrrol-2(5H)-one

Conditions

Conditions	Yield
With water; oxygen; rose bengal at 0℃; Irradiation;

...Expand

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Specification

The 1H-Pyrrole-2,5-dione,1-(2-hydroxyethyl)- is an organic compound with the formula C₆H₇NO₃. The IUPAC name of this chemical is 1-(2-Hydroxyethyl)pyrrole-2,5-dione. With the CAS registry number 1585-90-6, it is also named as N-2-Hydroxy-ethymaleimide. The product's category is Pharmacetical. Besides, its molecular weight is 141.12.

Physical properties about 1H-Pyrrole-2,5-dione,1-(2-hydroxyethyl)- are: (1)ACD/LogD (pH 5.5): -0.81; (2)ACD/LogD (pH 7.4): -0.81; (3)ACD/BCF (pH 5.5): 1; (4)ACD/BCF (pH 7.4): 1; (5)ACD/KOC (pH 5.5): 8.6; (6)ACD/KOC (pH 7.4): 8.6; (7)#H bond acceptors: 4; (8)#H bond donors: 1; (9)#Freely Rotating Bonds: 3; (10)Polar Surface Area: 46.61 Å²; (11)Index of Refraction: 1.56; (12)Molar Refractivity: 32.73 cm³; (13)Molar Volume: 101.1 cm³; (14)Polarizability: 12.97×10^-24 cm³; (15)Surface Tension: 60.4 dyne/cm; (16)Density: 1.395 g/cm³; (17)Flash Point: 138 °C; (18)Enthalpy of Vaporization: 63.19 kJ/mol; (19)Boiling Point: 304.5 °C at 760 mmHg; (20)Vapour Pressure: 8.27E-05 mmHg at 25 °C.

Uses of 1H-Pyrrole-2,5-dione,1-(2-hydroxyethyl)-: it can be used to produce 2-Maleimidoethyl chloroformiate. It will need reagent Et₃N and solvent CH₂Cl₂ with reaction time of 72 hours. The yield is about 80%.

You can still convert the following datas into molecular structure:
(1)InChI: InChI=1/C6H7NO3/c8-4-3-7-5(9)1-2-6(7)10/h1-2,8H,3-4H2
(2)InChIKey: AXTADRUCVAUCRS-UHFFFAOYAR
(3)Std. InChI: InChI=1S/C6H7NO3/c8-4-3-7-5(9)1-2-6(7)10/h1-2,8H,3-4H2
(4)Std. InChIKey: AXTADRUCVAUCRS-UHFFFAOYSA-N