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158722-22-6

Basic Information
CAS No.: 158722-22-6
Name: (4S,5R)-2,4-diphenyl-4,5-dihydrooxazole-5-carboxylic acid
Article Data: 14
Molecular Structure:
Molecular Structure of 158722-22-6 ((4S,5R)-2,4-diphenyl-4,5-dihydrooxazole-5-carboxylic acid)
Formula: C16H13NO3
Molecular Weight: 267.284
Synonyms: (4S,5R)-2,4-Diphenyl-4,5-dihydro-1,3-oxazole-5-carboxylic acid;
Density: 1.27±0.1 g/cm3(Predicted)
Melting Point: 203-204℃
Boiling Point: 486.3±45.0 °C(Predicted)
PSA: 58.89000
LogP: 2.09350
Synthetic route
146848-91-1

(4S,5R)-2,4-diphenyl-2-oxazoline-5-carboxylic acid methyl ester

158722-22-6

(4S,5R)-2,4-diphenyl-4,5-dihydrooxazole-5-carboxylic acid

Conditions
ConditionsYield
With sodium hydroxide96%
With sodium hydroxide In methanol; water at 20℃;86%
With sodium hydroxide In methanol; water at 20℃; for 5h;86%
With hydrogenchloride; sodium hydroxide76%
With sodium hydroxide In water
1251618-11-7

(-)-menthyl (4S,5S)-2,4-diphenyl-4,5-dihydrooxazole-5-carboxylate

158722-22-6

(4S,5R)-2,4-diphenyl-4,5-dihydrooxazole-5-carboxylic acid

Conditions
ConditionsYield
Stage #1: (-)-menthyl (4S,5S)-2,4-diphenyl-4,5-dihydrooxazole-5-carboxylate With water; potassium carbonate In methanol at 20℃;
Stage #2: With hydrogenchloride In water pH=2;
81%
1251618-08-2

(-)-menthyl (4S,5R)-2,4-diphenyl-4,5-dihydrooxazole-5-carboxylate

158722-22-6

(4S,5R)-2,4-diphenyl-4,5-dihydrooxazole-5-carboxylic acid

Conditions
ConditionsYield
Stage #1: (-)-menthyl (4S,5R)-2,4-diphenyl-4,5-dihydrooxazole-5-carboxylate With water; potassium carbonate In methanol at 20℃; for 5h;
Stage #2: With hydrogenchloride In water pH=2;
79%
216769-41-4

(4S-trans)-4,5-dihydro-2,4-diphenyl-5-vinyloxazoline

158722-22-6

(4S,5R)-2,4-diphenyl-4,5-dihydrooxazole-5-carboxylic acid

Conditions
ConditionsYield
With ruthenium trichloride; sodium periodate; sodium hydrogencarbonate In tetrachloromethane; water; acetonitrile for 48h;78%
With ruthenium trichloride; sodium periodate; sodium hydrogencarbonate In tetrachloromethane; water; acetonitrile for 48h; Oxidation; degradation;
sodium periodate (NaIO4)

sodium periodate (NaIO4)

216769-41-4

(4S-trans)-4,5-dihydro-2,4-diphenyl-5-vinyloxazoline

158722-22-6

(4S,5R)-2,4-diphenyl-4,5-dihydrooxazole-5-carboxylic acid

Conditions
ConditionsYield
With sodium hydrogencarbonate; ruthenium(III)chloride In tetrachloromethane; water; acetonitrile75%
229648-90-2

N-((1S,2S,3R)-3,4-Dihydroxy-2-iodo-1-phenyl-butyl)-benzamide

158722-22-6

(4S,5R)-2,4-diphenyl-4,5-dihydrooxazole-5-carboxylic acid

Conditions
ConditionsYield
With sodium chlorite; sodium periodate; sodium dihydrogenphosphate 1.) acetone, H2O, RT, 2.) 2-methyl-2-butene, t-BuOH, H2O, RT; Yield given; Multistep reaction;
56816-81-0

(2R,3S)-2,3-dihydroxy-3-phenyl-propionic acid

100-47-0

benzonitrile

158722-22-6

(4S,5R)-2,4-diphenyl-4,5-dihydrooxazole-5-carboxylic acid

Conditions
ConditionsYield
With sulfuric acid at -10 - 20℃;
688362-45-0

(4S,5R)-[2,4-diphenyl-(5-hydroxymethyl)]-1,3-oxazoline

158722-22-6

(4S,5R)-2,4-diphenyl-4,5-dihydrooxazole-5-carboxylic acid

Conditions
ConditionsYield
With pyridinium chlorochromate In N,N-dimethyl-formamide for 2h;
132201-32-2

(2R,3S)-3-phenylisoserine hydrochloride

158722-22-6

(4S,5R)-2,4-diphenyl-4,5-dihydrooxazole-5-carboxylic acid

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: NaOH / H2O
View Scheme
Multi-step reaction with 2 steps
1: 41 percent / toluene / 8 h / Heating
2: 86 percent / NaOH / methanol; H2O / 20 °C
View Scheme
707-07-3

orthobenzoic acid trimethyl ester

158722-22-6

(4S,5R)-2,4-diphenyl-4,5-dihydrooxazole-5-carboxylic acid

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: NaOH / H2O
View Scheme
Multi-step reaction with 2 steps
1: 41 percent / toluene / 8 h / Heating
2: 86 percent / NaOH / methanol; H2O / 20 °C
View Scheme
Multi-step reaction with 2 steps
1: 41 percent / toluene / 8 h / Heating
2: 86 percent / NaOH / methanol; H2O / 20 °C
View Scheme
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  • (4S,5R)-2,4-Diphenyl-4,5-dihydrooxazole-5-carboxylic acid

  • Casno:

    158722-22-6

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    158722-22-6

    (4S,5R)-2,4-diphenyl-4,5-dihydrooxazole-5-carboxylic acid

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  • 5-Oxazolecarboxylic acid, 4,5-dihydro-2,4-diphenyl-, (4S,5R)-

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    158722-22-6

    5-Oxazolecarboxylic acid, 4,5-dihydro-2,4-diphenyl-, (4S,5R)-

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